Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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A stacking machine learning model for identifying comorbid anxiety disorder in children and adolescents with functional abdominal pain disorders
ObjectiveComorbid anxiety disorder is common in children and adolescents with functional abdominal pain disorders, but clinically usable risk-stratification tools integrating abdominal pain, psychosocial, school-related, and family-level information remain limited.MethodsIn this observational predictive modeling study, children and adolescents aged 7–18 years…
Attitudes toward treating functional neurological disorders: psychological service provider perspectives
IntroductionFunctional neurological disorders (FND) are characterized by involuntary sensory, motor, and/or other seemingly neurological symptoms lacking expected medical explanation. Once diagnosed, patients often are referred to mental health providers for psychotherapy, which is effective in treating many FND symptom presentations…
From single pathways to holistic networks: unraveling the multimechanistic actions of acupuncture in depression
Depression is a globally prevalent mental disorder; however, current pharmacological treatments are limited by a delayed onset of action and significant adverse effects. As a safe and effective non-pharmacological therapy, acupuncture demonstrates unique advantages in treating mild to moderate depression.…
When support becomes dependence: conversational continuity and relational safety in human-AI interaction
BackgroundConversational artificial intelligence (AI) is increasingly used for emotional support, reflection, and consequential decision-making. Although conversational continuity may improve responsiveness, sustained interaction also exposes AI systems to their own prior relational language, potentially shaping how they respond when users become…
Positive–affective and negative–cognitive brain–behavior axes in clinical high risk for psychosis
Individuals at clinical high risk for psychosis (CHR) present with heterogeneous combinations of positive, negative, and affective symptoms, cognitive difficulties, and functional impairment. However, reproducible multivariate links between this multidomain phenotype and brain morphology remain limited. This study explored the…
A Clinical Trial to Evaluate the Efficacy and Safety of Meltz, a Digital Therapeutic Device, for Improving Panic Symptoms in Patients With Panic Disorder
Conditions: Panic Disorder; Agoraphobia Interventions: Device: Meltz; Device: Sham Application Sponsors: AIMNEXT; Korea University Anam Hospital; Kangbuk Samsung Hospital; National Traffic Injury Rehabilitation Hospital; CHA University Not yet recruiting
Rosie en Español, a Chatbot-Delivered Intervention for Spanish-Speaking, US-Based Latina Mothers: Pilot Randomized Controlled Trial
Background: Latina pregnant women and mothers of infants in the United States experience elevated risk for perinatal anxiety, stress, and depression alongside persistent barriers to culturally and linguistically responsive care. AI-powered digital health tools offer a potentially scalable approach to…
What Living With OCD Really Feels Like
“I view having OCD like living inside a glass box while holding the keys to the door.” Adolfo Flores-Quilcate shares what rumination, diagnosis, and ERP have taught him — and why he believes healing is possible. The post What Living…
Microglia in the neurogenic niche: emerging roles of immunometabolism
Adult neurogenesis is dynamically regulated by the neurogenic niche, yet the mechanisms governing its remodeling are not fully elucidated. Current research has increasingly extended beyond the intrinsic properties of neural stem cells to consider the broader microenvironment in which neurogenesis…
ADHD-related mental health and school impairments across educational stages: sex-specific patterns in Japanese youth
IntroductionWhile ADHD-related challenges are well-documented internationally, understanding of how these manifest across educational stages and sexes remains limited. This study examined mental health symptoms and school functioning in Japanese children with and without ADHD across elementary, junior high, and senior…
Outcome indicators used in recovery college effectiveness studies: a scoping review
IntroductionRecovery Colleges (RCs) are educational, recovery-oriented approaches in mental health. Differences in evaluation purposes and settings may lead to diverse outcome indicators, making it important to map their use and supporting measurement evidence. This scoping review aimed to identify the…
Psychopathy is a key to integrating dimensional personality disorder constructs and psychotherapy: toward a reformulation of personality and its disruption
While the conceptualization of personality disorder (PD) moves toward a dimensional approach, the broader adoption within clinical practice appears slow. The lack of a unifying framework in diagnostic classifications might explain this issue. Here, psychopathy, arguably the most pervasive and…
STAT+: Telehealth leapfrogs FDA approval with off-label GLP-1 prescriptions for addiction
As telehealth promotes GLP-1s for addiction, experts worry about fragmented care, and exposing patients to unknown risks.
Evaluating the PolarUs App in People With Bipolar Disorder
Conditions: Bipolar Disorder (BD); Quality of Life (QOL) Interventions: Device: PolarUs Mobile App Sponsors: University of British Columbia; Canadian Institutes of Health Research (CIHR) Not yet recruiting
Assisting Screening of Adolescent Depression With Large Language Models as Symptom Detectors: Algorithm Development and Validation
Background: Depression prevalence is rising in adolescents and young adults (ages 10-24 years). Traditional screening methods for depression, such as the Patient Health Questionnaire (PHQ-9), are particularly challenging for adolescents. AI has potential to help with this, but the scarcity…
An Education and Support Chatbot for Postpartum Mothers With Opioid Use Disorder: Qualitative Needs Assessment
Background: The prevalence of opioid use disorder (OUD) among women giving birth in US hospitals continues to rise. Increasing fatalities due to perinatal drug overdose have in part been attributed to decreased access to social support and treatment services. In…
Depressive symptoms and occupational correlates among psychiatric nurses in northern Jiangsu: an explanatory sequential mixed-methods study
BackgroundPsychiatric nurses manage aggression, interrupted recovery and emotionally demanding care. Surveys quantify distress but rarely show how these experiences accumulate during routine work.AimWe aimed to estimate the prevalence of a positive depressive-symptom screen among psychiatric nurses and to quantify its…
Psychiatric service dogs reduce loneliness and improve social functioning in adults with mental health conditions: a qualitative study from South Africa
IntroductionLoneliness and impaired social functioning are clinically significant features of mental illness. Psychiatric service dogs (PSDs) are individually trained to perform tasks that mitigate the functional impact of psychiatric disability and have been proposed as an intervention for loneliness and…
Beyond diagnostic categories: transdiagnostic psychological mechanisms associated with suicidal ideation among university students: a systematic review (2021–2025)
IntroductionConventional diagnostic categories may not fully capture the psychological processes associated with suicidal ideation among university students. This systematic review synthesized recent evidence on candidate transdiagnostic psychological mechanisms, distinguishing ideation-specific findings from broader suicide-related outcomes.MethodsScopus, Web of Science, PubMed, and…
Simultaneous measurement of Midbrain and Striatal Dopamine in Schizophrenia using an agonist radiotracer
Imaging studies showing greater amphetamine-induced dopamine release in patients with schizophrenia (SCZ) compared to matched healthy controls (HC) have been repeatedly replicated, but these studies all used radiotracers that were dopamine D2 receptor antagonists. A more recent study using an…

