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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Purrble Use Among LGBTQ+ Young People With Self-Harm Experiences: Findings From a Qualitative Process Evaluation of a Randomized Controlled Trial
Background: Difficulties with emotion regulation (ER) have widely been associated with the development and persistence of poor mental health, such as depression, anxiety, self-harmful thoughts, behaviors, and suicide attempts. Despite the importance of ER as a transdiagnostic risk factor, few…
Early Research Shows How Postnatal Depression May Affect Offspring
Research suggests that specific microRNAs in breast milk could at least partly explain why many children of women with postnatal depression experience developmental and behavioral problems. The post Early Research Shows How Postnatal Depression May Affect Offspring appeared first on…
Characteristic Facial Expressions During Visual Fixation in Japanese Older Adults With Lower Cognitive Screening Performance: Exploratory Cross-Sectional Study
Background: Early identification of older adults with lower cognitive screening performance may facilitate appropriate clinical evaluation and intervention to delay the progress of cognitive decline and onset of dementia. Because facial information can be acquired noninvasively and unobtrusively during everyday…
Effects of Telerehabilitation on Quality of Life, Physical Capacity, and Symptom Burden Within the Post–COVID-19 Condition: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background: Post–COVID-19 condition (PCC) is characterized by persistent symptoms and functional limitations that impair quality of life, and rehabilitation is an important component of its management. Because access to conventional face-to-face rehabilitation may be limited, telerehabilitation has emerged as an…
Stress-induced dorsal striatal dopamine release is associated with changes in functional connectivity to the prefrontal cortex in nicotine-dependent individuals—a preliminary report
IntroductionThe neural mechanism linking stress to addiction pathophysiology remains unclear. A proposed pathway involves stress-induced dopamine (DA) transmission impairing inhibitory control, leading to relapse. Lipopolysaccharide (LPS), a biological stressor inducing systemic inflammation, amplifies DA release. Our prior study demonstrated this…
Case Report: Severe depression and suicidality in a young patient with RYR1-related congenital myopathy
BackgroundRYR1-related congenital myopathies (RYR1-CMYO) are rare inherited neuromuscular disorders characterized by considerable clinical and histopathological heterogeneity. Although chronic physical disability may be associated with substantial psychological burden, psychiatric manifestations in patients diagnosed with RYR1-related disorders remain insufficiently characterized.Case presentationWe report…
Family cohesion and adolescent self-esteem: mediating effects of interpersonal self-support and moderating role of school attachment
IntroductionAdolescent mental health is a pressing global concern, and in collectivist societies such as China, family and school contexts are particularly influential. This study examined whether interpersonal self-support mediates the association between family cohesion and self-esteem among Chinese adolescents and…
When severe violence becomes a script: a vulnerability-script integration model of media exposure and the form of psychosis-associated maternal filicide
When a publicized act of severe violence is followed by one that resembles it, the resemblance is often read as contagion. This paper argues that resemblance is weak evidence of influence and asks a narrower question: under what conditions can…
AI-Based CBT Chatbot for Adolescent Social Anxiety
Conditions: AI-CBT Intervention Group; Waitlist Control Group Interventions: Behavioral: AI-CBT intervention group Sponsors: Central China Normal University Not yet recruiting
A Comparison of Heart Rate Variability Biofeedback, Mindfulness, and Psychoeducation-based Interventions on Clinical Recovery Outcomes in Patients Undergoing Total Knee Arthroplasty
Conditions: Pain (Knee); Pain and Anxiety; TKA Interventions: Behavioral: Heart rate variability biofeedback; Behavioral: Mindfulness; Behavioral: psychoeducation Sponsors: Chang Gung Memorial Hospital Recruiting
Integrated Psychoeducation Program for Internalized Stigma in Schizophrenia
Conditions: Schizophrenia; Schizoaffective Disorder; Internalized Stigma; Social Stigma Interventions: Behavioral: Integrated Psychoeducation Program Sponsors: Dokuz Eylul University Not yet recruiting
The focus on AI safety disasters ignores everyday harms
Consider what passes for success in technology policy. An AI company promises that its chatbot will not encourage suicide. A social media platform makes it more difficult for children to buy fentanyl. These are important protections, and they should have…
Correlation between hypothalamic-pituitary-adrenal function and clinical characteristics in the acute phase of first-episode drug-naive major depressive disorder
BackgroundFirst-episode drug-naïve depressive disorders have high heterogeneity in clinical features, and there is still room for in-depth exploration of the correlation with serum cortisol levels. This study aimed to explore the correlation between hypothalamic-pituitary-adrenal (HPA) function in the acute phase…
Multiscale EEG network alterations in adolescents with depressive symptoms: static–dynamic connectivity, topological features, and exploratory scalp-level network hubs
BackgroundAdolescence is a critical period for brain network development and a vulnerable stage for the emergence of depressive symptoms Although altered brain connectivity has been reported in depression, the multiscale organization of resting-state EEG networks in adolescents with depressive symptoms…
Predicting behavioral escalation in students with autism using physiological and movement data
IntroductionBehavioral escalation in students with Autism Spectrum Disorder (ASD) presents significant challenges in educational and community settings, often leading to reactive interventions after behaviors become observable. This study investigated whether physiological and movement data obtained from wearable biometric sensors could…
Phase 1: Thrive Together: A Feasibility and Acceptability Evaluation of Peer Mentoring for High Schoolers With ADHD and Their Caregivers
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD) Sponsors: Boston Children's Hospital; YMCA Not yet recruiting
TRIal of PPF3 vs. PlaCEbo in the TReatment of Children and AdolescenTs With NeurOdeveloPmental DisorderS
Conditions: Autism Disorder Interventions: Drug: PPF3; Drug: Placebo Sponsors: Holland Bloorview Kids Rehabilitation Hospital; Ontario Brain Institute (Funder); Purposeful Recruiting
Human-in-the-Loop Suicide Risk Detection and Clinical Escalation in a Generative AI Mental Health Chatbot: Prospective Implementation Study
Background: Mental illness is a leading cause of disability worldwide, affecting more than 1 billion people, and suicide accounts for 720,000-800,000 deaths annually. Although AI-native mental health chatbots have the potential to help address the substantial gap between treatment needs…
Meta Mesh Ontology for Cross-Domain Mental Health Knowledge Integration: Development and Evaluation Study
Background: Psychiatric diagnostic practice faces persistent challenges in adequately capturing the complexity, heterogeneity, and dynamic nature of mental disorders. Conventional categorical classification systems such as the and the rely on rigid symptom-based criteria that often fail to represent multifactorial etiologies,…
Comparison of short-term peripheral nerve stimulation, single-target supraorbital nerve pulsed radiofrequency, and dual-target supraorbital nerve–stellate ganglion pulsed radiofrequency for herpes zoster ophthalmicus–associated pain: a retrospective cohort study
ObjectiveTo compare the clinical outcomes of short-term peripheral nerve stimulation (st-PNS), supraorbital nerve pulsed radiofrequency (SON-PRF), and combined supraorbital nerve and stellate ganglion pulsed radiofrequency (SON + SG-PRF) for herpes zoster ophthalmicus (HZO)-associated pain.MethodsThis retrospective study included patients with HZO-associated pain who…