Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Emerging Adults’ Experiences of Digital Measurement-Based Care in Routine Mental Health Care: Qualitative Study and Conceptual Synthesis
Background: Emerging adults (aged 18‐29 years) experience a high burden of mental health (MH) concerns during a developmental period marked by increasing autonomy and vulnerability to symptom onset. Many emerging adults face challenges in accessing and sustaining engagement with developmentally…
A Mobile App for Student Veterans With Co-Occurring Academic and Psychiatric Concerns: Pilot Usability and Feasibility Study
Background: Over 600,000 student veterans use military benefits to pursue higher education annually, with 75% enrolled as full-time students. Advancing their education is an important step toward improving their employment, financial, and social opportunities. However, student veterans also experience high…
Therapist Skepticism and Adaptation to Teletherapy Under Enforced Uptake, With Theoretical Considerations for AI-Mediated Care: Qualitative Study
Background: Mental health care is undergoing rapid digital transformation, with continued development and implementation of digitally delivered interventions. Despite growing evidence for digital mental health interventions, implementation in routine practice has often lagged technological advances. Although teletherapy became more widely…
Comparative efficacy of neuromodulation techniques for Alzheimer’s disease: a systematic review and network meta-analysis of randomized controlled trials
BackgroundNeuromodulation techniques (NMTs) have shown potential therapeutic value in Alzheimer’s disease (AD), but the comparative efficacy of different modalities remains unclear. This study aimed to systematically compare and rank available NMTs to identify their relative benefits across cognitive, functional, and…
Large language models for late-life depression: a blinded benchmark of clinical safety, geriatric appropriateness, and triage
BackgroundGeneral-purpose large language models are increasingly used by patients and caregivers to obtain mental health information and guidance about when professional care is required. In late-life depression, broadly accurate information may nevertheless be unsafe when cognitive change, multimorbidity, frailty, polypharmacy,…
Recovery-phase symptoms after COVID-19 infection and anxiety levels among college students
ObjectiveThis study examines the relationship between physical symptoms during the recovery phase after COVID-19 infection and anxiety levels among college students, with the aim of providing empirical evidence for post-pandemic mental health screening and health management in universities.MethodsThe study used…
An Evidence-Based AI Virtual Assistant for Young People With Attention Deficit Hyperactivity Disorder: Co-Design and Prototype Development
Background: Though attention deficit hyperactivity disorder (ADHD) is thought to be the most prevalent neurodevelopmental disorder in young people worldwide, there are inequalities in access to psychoeducation and health care support. One way to improve access, potentially increase engagement, reduce…
Tool or Companion? Reframing Conversational AI to Prevent Psychological Harm
People increasingly turn to conversational AI for companionship, emotional support, and well-being, using both purpose-built companion apps, such as Replika and Character.AI, and general-purpose assistants, such as ChatGPT and Claude. While some evidence suggests potential benefits, including short-term reductions in…
Renaclic for Chronic Kidney Disease Self-Management: Formative User-Centered Co-Design Study
Background: Chronic kidney disease (CKD) affects over 850 million individuals worldwide and requires sustained patient education, shared decision-making, and self-management support. Digital health platforms may facilitate these needs; however, many lack comprehensive, user-centered design and fail to address practical and…
Autistic traits and obsessive–compulsive symptom severity: a retrospective six-month follow-up study
Autistic traits have been increasingly associated with obsessive–compulsive disorder (OCD), yet their influence on longitudinal symptom severity and treatment-related change remains poorly understood. This retrospective longitudinal study included 38 adults with DSM-5 OCD who completed six months of guideline-based pharmacological…
Neurodiversity as an epistemic stress test for psychotherapy and health care: a neuroaffirmative conceptual analysis of relational-proximity priors in clinical, institutional, and AI-supported models
Neurodiversity-affirming mental health care requires not only adapting support to neurodivergent people but also examining the relational assumptions through which alliance, empathy, cooperation, progress, and risk are interpreted. This Conceptual Analysis develops the heuristic concept of relational-proximity priors: implicit assumptions…
Association of iron deficiency and iron-deficiency anemia with behavioral problems in children with autism: a cross-sectional study
PurposeIron deficiency (ID) and iron deficiency anemia (IDA) are common in children with autism spectrum disorder (ASD) and may contribute to behavioral problems. We examined their association with internalizing and externalizing behavioral problems.MethodsThis cross-sectional study (October 2023 to March 2025)…
Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health
Conditions: Anxiety; PTSD; ADHD; Depression Disorders; Post-traumatic Stress; Substance Use; Executive Function; Sleep Disturbance Interventions: Behavioral: AIP-Informed Integrative Psychotherapy; Device: Transcutaneous Auricular Vagus Nerve Stimulation; Behavioral: Regulated Breathing and Autonomic Regulation; Device: Audiovisual Entrainment; Device: Vibroacoustic Stimulation; Behavioral: Breathwork-Based Auditory…
Personalising ADHD Medication Treatment for Children and Young People
Conditions: ADHD Interventions: Other: PETRA decision-aid tool; Other: Best-evidence decision-support tool Sponsors: University of Southampton Not yet recruiting
Heart Rate Variability Biofeedback for Anxiety in Autistic Youth
Conditions: Autism Spectrum Disorder; Anxiety Interventions: Device: Lief Smart Patch Sponsors: Massachusetts General Hospital; Eagles Autism Foundation Not yet recruiting
Evaluating the Effects of StrongMinds Community-Based Group Interpersonal Therapy on Depression and Secondary Outcomes in Uganda
Conditions: Depression - Major Depressive Disorder Interventions: Behavioral: Group Interpersonal Therapy (IPT-G); Behavioral: Enhanced treatment as usual Sponsors: IDinsight; StrongMinds Active, not recruiting
Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis
Conditions: First Episode Psychosis (FEP); Psychosis; Schizophreni-form Disorder; Dependence Addictive Interventions: Other: CHAMPS; Other: I Can Change Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Integrated University Health and Social Services Center of the Capitale-Nationale; Nova Scotia Health Authority; Centre…
Facing Fears From Home: Development, Feasibility and Maximization of FobiApp
Conditions: Specific Phobia Interventions: Behavioral: FobiApp AR Exposure therapy, Self-administered augmented reality exposure for cockroach phobia; Behavioral: FobiApp AR Exposure therapy + ABM, Self- administered augmented reality exposure combined with attentional bias modification training for cockroach phobia. Sponsors: Universitat Jaume…
Nonlinear associations of BMI and body dissatisfaction with depression and an exploratory decomposition of the indirect association: a cross-sectional study of Chinese university students
ObjectiveThis study aimed to examine the non-linear associations of body mass index (BMI) and body dissatisfaction with depressive symptoms among Chinese university students, and to explore how the indirect association between BMI and depressive symptoms through body dissatisfaction varies across…