Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Exploratory cluster analysis of self-reported adverse events associated with antidepressants using Gower distance and partitioning around medoids: a single-center cross-sectional study
BackgroundAntidepressants are first-line pharmacological interventions for depressive disorders, with globally increasing prescription volumes. Associated adverse events (AEs) represent the primary reason for treatment discontinuation. Existing studies mostly limit analysis to simple stratification by organ system or severity, while exploratory subtyping…
PROMATER: protocol for a randomized controlled trial of a digital self-guided intervention to promote perinatal mental health and reduce self-criticism
BackgroundPerinatal mental health represents a significant public health concern given the high prevalence of mental disorders during pregnancy and the postpartum period and their impact on maternal well-being, mother-infant bonding, and child development. Emerging evidence identifies self-criticism as a transdiagnostic…
Association between first-trimester serum 25(OH)D and EPDS-positive postpartum depressive symptoms in women with gestational diabetes mellitus: a retrospective cohort study
IntroductionGestational diabetes mellitus (GDM) has been associated with an increased risk of postpartum depressive symptoms, while maternal vitamin D status may also be related to perinatal mood disturbances. This study investigated the association between first-trimester serum 25-hydroxyvitamin D [25(OH)D] concentrations…
Body-based therapies and transcranial magnetic stimulation for posttraumatic stress disorder: a proposed integrative approach
Posttraumatic stress disorder (PTSD) remains difficult to treat, with 30–50% of patients retaining their diagnosis after first-line trauma-focused psychotherapies. Body-based therapies (BBTs) and transcranial magnetic stimulation (TMS) have each shown preliminary benefit for PTSD but have not yet been studied…
Perinatal mental health equity: patient perspectives on virtual collaborative care providing what women need now in the post-COVID era
IntroductionThe COVID-19 pandemic increased perinatal mental health needs and disrupted routine obstetric care, disproportionately affecting Black and economically disadvantaged communities. Michigan’s Perinatal Collaborative Care Model (Peri CoCM), a publicly funded virtual program, launched during the pandemic and continued after the…
Problematic Reliance on Generative AI in an Anxious Young Adult: Case Report
Generative Artificial Intelligence (AI) tools are increasingly integrated into daily life, offering cognitive support across domains such as writing, decision-making, and social interpretation. While beneficial, excessive reliance may contribute to diminished confidence in one’s own thinking. This report describes a…
Caregiver Challenges and Functional Requirements for an mHealth App Supporting Home-Based Dementia Care: Qualitative Interview Study
Background: The growth of the older adult population in Indonesia since 2019 has contributed to a 2.46% increase in dementia cases, with the number of cases projected to increase 2.5-fold by 2050. This trend is exerting a major impact on…
Brain Protein in Mice Offers Insights Into Brain Development and ADHD
Researchers identified a brain protein, NSF, that is important for maintaining dopamine-related cells and normal development, providing new insights into ADHD and potential therapeutic strategies. The post Brain Protein in Mice Offers Insights Into Brain Development and ADHD appeared first…
Ethical and Legal Considerations in the Collection and Analysis of Mental Health Lived Experience Narratives: Reflections on 4 Case Studies of Research Practice
Personal narratives describing lived experiences of the entire spectrum of mental health challenges are now widely available to the public, including through autobiographies from public figures, thematic collections of narratives assembled by mental health organizations, and individual narratives published on…
Virtual Reality–Assisted Therapy Compared to Cognitive Behavioral Therapy for Patients With Treatment-Resistant Schizophrenia: Assessor-Blind Randomized Controlled Trial
Background: Auditory verbal hallucinations (AVH) are among the most disabling symptoms of schizophrenia and often persist despite treatment. Virtual reality–assisted therapies (VRTs) are a new generation of relational interventions for AVH, but comparative evidence against active interventions is currently lacking.…
Psychological Therapy in the Age of Large Language Models: Framework for Therapist-Delivered and AI-Supported Functions
Large language models are increasingly used within and alongside therapy. As large language models perform more therapy functions, questions arise about what the future might hold for therapists and what they will do. We argue that the enduring therapist role…
Human Cortical Organoids Expand Across a Cortex-Depleted Mouse Brain
A new xenocortication model enables human neurons to grow, form long-range projections, and integrate with host circuitry, removing major constraints on modeling human neuronal development and disease. The post Human Cortical Organoids Expand Across a Cortex-Depleted Mouse Brain appeared first…
Transcutaneous auricular vagus nerve stimulation targets the brain-gut axis to treat functional dyspepsia: a scoping review of clinical evidence and mechanistic research
BackgroundFunctional dyspepsia (FD) is a common gut–brain interaction disorder with suboptimal response to pharmacotherapy. Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive neuromodulation targeting the vagus nerve, has emerged as a promising brain–gut axis therapy. This scoping review (PRISMA-ScR, JBI…
Associations of weight change with perceived stress and depression: a nationwide population-based study
PurposeDepression and perceived stress are prevalent mental health problems worldwide, closely associated with physical health. Prior studies have suggested that both weight gain and loss may increase the odds of depression and stress, highlighting the need for clarification using national…
Efficacy of mindfulness-based interventions for children and adolescents with attention deficit hyperactivity disorder: a systematic review and meta-analysis
Background and objectiveAttention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood. Although mindfulness-based interventions (MBIs) have been proposed as promising non-pharmacological treatments, evidence regarding their efficacy in children and adolescents with ADHD remains inconsistent.MethodsA systematic search of…
Summary of current evidence for digital health interventions in the screening and management of postpartum depression
AimTo identify, appraise, summarise, and synthesise current evidence on digital health strategies for postpartum depression (PPD) screening and management, and to develop practice-oriented recommendations to support evidence-informed clinical nursing practice.MethodsUsing the 6S evidence hierarchy to guide the retrieval sequence, we…
Investigation of psychiatric symptoms, dissociative experiences, and childhood trauma in allergic rhinitis, and evaluation of the clinical relationship between these factors
BackgroundIn this study, we aimed to evaluate levels of depression and anxiety symptoms, childhood trauma, and dissociative experiences in patients with allergic rhinitis (AR) and compare them with healthy controls. Additionally, investigate the association between childhood trauma, depressive symptoms, and…
Leveraging Scalable Non-Mammalian Systems for Large-Scale Studies of Autism Risk Gene Function
There are over 100 large-effect genes strongly associated with autism spectrum disorder (ASD), yet advancing from risk genes to the discovery of common biological pathways and pharmacological targets remains a central challenge. Scalable non-mammalian systems, including Caenorhabditis elegans (roundworm), Drosophila…
A Smartphone-Based Acoustic Machine Learning Pipeline for Detecting Suicidal Ideation: Case-Control Model Development and Validation Study
Background: Suicidal ideation (SI) among university students is a growing public health concern. Self-report screening can be limited by concealment and delayed disclosure. We evaluated a leakage-resistant, proof-of-concept pipeline to detect SI from standardized smartphone-recorded speech. Objective: This study aimed…
SNF Global Center to Convene Second Global Summit on Youth Mental Health
Following the success of the inaugural summit, this year’s event will further bridge science, storytelling, and lived experience through breakout sessions, new research and evidence, interactive activations, networking, and notable guest appearances. The post SNF Global Center to Convene Second Global Summit…