Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Latent profile analysis of sleep quality and associated factors in Chinese adolescents with major depressive disorder
BackgroundSleep disturbances are pervasive among adolescent patients with major depressive disorder (MDD), yet the heterogeneity of sleep phenotypes within this population remains underexplored. This study aimed to identify latent profiles of sleep quality in Chinese adolescent patients with MDD and…
Repetitive Transcranial Magnetic Stimulation Versus Theta Burst Stimulation on Impulsivity, Emotional Dysregulation, and Non-Suicidal Self-Injury in Borderline Personality Disorder Patients
Conditions: Borderline Personality Disorder (BPD) Interventions: Device: Repetitive Transcranial Magnetic Stimulation; Device: Intermittent Theta-Burst Stimulation; Device: Sham Stimulation Sponsors: Ain Shams University Recruiting
Affective Cognitive Training in Mood Disorders and High-risk Relatives
Conditions: Major Depressive Disorder (MDD); Bipolar Disorder (BD) Interventions: Behavioral: Targeted affective cognitive training Sponsors: Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital Recruiting
Compassion-Focused Implementation of Smartwatches in Acute Mental Health Care: Mixed Method Replicated Single-Case Study
Background: Smartwatches can support mental health care by providing insights into activity and sleep, which are closely linked to mental health and daily functioning. However, their implementation in mental health care practice remains limited. Professionals can feel resistance toward digital…
The Effect of Bipolar Disorder Illness Course on Physiological Digital Signals: Observational Study
Background: Although bipolar disorder (BD) lacks objective biomarkers of illness progression, wearable devices enable continuous, real-world collection of physiological digital biosignals, offering a promising approach to address this gap. Measures such as electrodermal activity (EDA) and heart rate variability (HRV)…
Mental health outcomes following COVID-19- associated caregiver loss in children and adolescents: a six-year evidence gap
By May 2022, an estimated 10.5 million children worldwide had lost a parent or caregiver to COVID-19. We found only two cohorts with quantitative mental-health data: one in Iran and the South African Orphanhood and Caregiver Loss Among Adolescents and…
Note2Narr: a neuro-symbolic multi-agent system for synthesizing high-fidelity training narratives from sparse counselor notes
IntroductionEarly identification of mental health risks among university students requires high-quality, privacy-conscious dialogue data for developing and evaluating computational screening models. Existing synthetic datasets often lack the contextual nuance and diagnostic consistency needed to preserve clinically relevant psychological signals.MethodsWe introduce…
Factors associated with medication experience in patients with schizophrenia: a mixed-methods study across three post-discharge time points
BackgroundSchizophrenia requires sustained antipsychotic therapy, yet medication adherence remains suboptimal in over 50% of patients due to suboptimal medication experiences, often leading to self-directed dose reduction or discontinuation. This non-adherence contributes to disease relapse, functional impairment, and substantial familial economic…
Be Body Brave: Digital Written Exposure Therapy for Eating Disorders
Conditions: Eating Disorders Interventions: Behavioral: Imaginal exposure; Behavioral: Eating disorder journaling Sponsors: University of Louisville; National Institute of Mental Health (NIMH) Not yet recruiting
Age-dependent structural brain aging in medication-free major depressive disorder: A multi-site analysis from COORDINATE-MDD consortium
Major depressive disorder (MDD) is associated with altered brain structure and accelerated brain aging. However, previous studies have been limited by clinical samples with mixed medication status and multiple mood states, modest sample sizes, underrepresentation of older adults with MDD,…
A Large Language Model–Based System for Depression Symptom Identification: Iterative Qualitative Co-Design Studies
Background: AI technologies have considerable potential to support mental health practitioners in identifying depression symptoms. However, existing tools are often developed with limited practitioner involvement and evaluated primarily on technical performance, leaving questions of clinical relevance, ethical design, and practitioner…
Social Desirability Bias in Health Screening Questionnaire Responses Generated by OpenAI Models: Quantitative Experimental Study
Background: Social desirability bias, the tendency to respond in ways that present the respondent favorably, is well documented in human self-report and has recently been observed in large language models (LLMs) completing personality inventories. Whether it also affects LLM responses…
Engagement Patterns and Clinical Outcomes Among Adolescents and Young Adults Enrolled in the Somethings Digital Peer Support Platform: Retrospective Observational Study
Background: Adolescent mental health needs remain largely unmet, particularly among youth in geographically underserved communities. Digital peer support is a promising approach to expanding access to mental health support, yet real-world evidence on engagement patterns and clinical outcomes remains limited.…
STAT+: Amid Mass General Brigham layoffs, CEO pens vague letter, stirring staff anxiety
A cryptic email sent to Mass General Brigham employees by the health system's CEO is stirring staff anxiety less than two weeks after a round of layoffs.
AI-Generated Exposure Hierarchies for Body Dysmorphic Disorder: Proof-of-Concept Study
Background: Body dysmorphic disorder (BDD) is a chronic, impairing condition for which cognitive behavioral therapy, including exposure and response prevention (ERP), is the first-line treatment, but few clinicians are trained in BDD-specific ERP. Constructing personalized exposure hierarchies is time-intensive and…
Integration of an FDA-Authorized Digital Autism Diagnostic Tool Into an Outpatient Developmental Pediatrics Workflow: Preliminary Quality Improvement Study
Background: Long wait times and specialist shortages delay autism spectrum disorder (ASD) diagnosis, often beyond the period when early intervention is most effective. Digital diagnostic tools may help increase diagnostic capacity by supporting clinicians in delivering timely autism evaluations within…
Caregiver burden, family resilience, and depressive and anxiety symptoms in parents of depressed adolescents: a cross-sectional mediation study
BackgroundParents of adolescents with depression experience substantial caregiving burden, contributing to an increased risk of psychological distress. While individual resilience has been associated with this relationship, the role of family-level resilience remains underexplored. This study explored whether family resilience statistically…
Symptom interactions of insomnia, anxiety, and depression in early pregnancy: a network analysis perspective
BackgroundPregnancy is a unique phase involving significant physical, social, and psychological changes, increasing vulnerability to anxiety, depression, and insomnia. These conditions are interrelated and often overlap, yet their symptom-symptom relationships during early pregnancy remain underexplored.MethodsA total of 1,830 women in…
Family Accommodation Reduction in Adult Obsessive Compulsive Disorder: A Randomized Controlled Trial
Conditions: Obsessive - Compulsive Disorder; Family Accommodation; OCD; CBT; Psychoeducation Interventions: Behavioral: Family Accommodation Reduction; Behavioral: Family Psychoeducation Sponsors: Karen Rowa; McMaster University; Sunnybrook Health Sciences Centre; St. Joseph's Healthcare Hamilton Enrolling by invitation
Inflammatory Process Identified as Link Between Pulmonary Hypertension and Cognitive Decline
A study investigating the observed connection between pulmonary hypertension and cognitive decline symptoms has linked brain abnormalities in pulmonary hypertension to the same inflammatory processes that drive disease in the lungs and heart. The post Inflammatory Process Identified as Link…