Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Looking Ahead to the SNF Global Center’s Second Annual Global Summit on Youth Mental Health
As mental health care, education, and research for youth advances, it is important to remember that in order to best serve young people, we must listen to their lived experience. The post Looking Ahead to the SNF Global Center’s Second…
Ultrasound neuromodulation in brain disorders: from mechanotransduction mechanisms to clinical translation
Brain disorders impose a major global health burden, yet current pharmacological and neuromodulation therapies are often constrained by invasiveness, limited spatial precision, poor access to deep brain structures, or insufficient long-term efficacy. Non-invasive ultrasound neuromodulation has emerged as a promising…
Efficacy of a personalized, response-based transdiagnostic intervention for emotional disorders delivered via the Internet: a protocol for an adaptive randomized controlled trial
One of the main challenges in clinical psychotherapy is disseminating effective psychological treatments to the millions who need them but lack access. Transdiagnostic interventions, particularly those delivered online, can help bridge this treatment gap. However, these interventions, often provided as…
Parental depressive symptoms and shared reading practices among preschool children in western China: cross-sectional study
BackgroundShared reading supports early child development, but parental depressive symptoms may reduce its frequency and quality. Most previous studies assumed linear relationships with small samples. This large cross-sectional study examined linear and non-linear associations between parental depressive symptoms and shared…
Body image dissatisfaction and emotional eating across age and weight status: a comparative cross-sectional study
BackgroundObesity in older adults is associated with significant medical, functional, and psychological consequences, including body image dissatisfaction and maladaptive eating behaviors such as emotional eating. Although these associations have been extensively studied in younger populations, limited evidence is available in…
Possible drivers of self-harm severity – relative contributions of post-traumatic stress and levels of personality functioning – results from the Extreme Challenges project
BackgroundSelf-harm (SH) is common, but its severity varies. Severe cases may involve extensive hospitalization and high suicide risk. Although SH is associated with post-traumatic stress disorder (PTSD), personality disorder (PD), and complex cases of PD-PTSD comorbidity, factors related to SH…
STAT+: Alkermes’ orexin agonist shows potential to treat ADHD in early-stage trial
The drugmaker Alkermes said a therapy called an orexin agonist for the first time showed potential to treat people with ADHD in an early-stage study.
Study on the Prevention of Weight Loss Through Physical Activity Among Nursing Home Residents
Conditions: Appetite Loss in Aging; Anorexia of Aging Interventions: Other: Physical activity; Other: Appetite assessment; Other: Food intake assessment; Other: Assessment of the efficiency; Biological: Blood test at baseline; Biological: Blood test at the end of the study; Other: Functional…
Attachment and Substance Use Disorder: An Interventional Study in an Addictology Day Hospital
Conditions: Addiction Disorders Interventions: Behavioral: attachment-focused therapeutic program; Behavioral: psychoeducation-based intervention (standard care) Sponsors: Centre Hospitalier de Cadillac Completed
A comparative study of traditional Chinese mind-body therapies on sleep quality, mental health, and quality of life in patients with sleep disorders: a network meta-analysis based on randomized controlled trials
BackgroundSleep disorders are a common clinical condition characterized primarily by difficulty falling asleep, trouble maintaining sleep, and impaired daytime functioning, with a high prevalence among adults. This condition can lead to a persistent decline in sleep quality, trigger mental health…
Palomar Labs Spins Out Ariadne Bio to Advance Non-Hallucinogenic Therapy for Parkinson’s Apathy
Backed by preclinical data and funding from The Michael J. Fox Foundation, Ariadne Bio is advancing AB-300, a serotonin 2A receptor agonist, as a potential treatment for Parkinson’s-related apathy. The post Palomar Labs Spins Out Ariadne Bio to Advance Non-Hallucinogenic…
Strategies to enhance engagement in CBT for adult ADHD: an innovation tournament with stakeholders
ObjectiveAdults with ADHD report challenges engaging in cognitive-behavioral therapy (CBT). This study investigates practices that might be applied to improve intervention fit and therapeutic engagement of CBT for adults with ADHD.MethodWe conducted an Innovation Tournament (IT) and member checking with…
School refusal behavior in children and adolescents: a concept analysis
School refusal behavior (SRB) is increasingly recognized across educational, pediatric, and mental health settings, yet its conceptual boundaries remain unclear, and the term is frequently conflated with school refusal, truancy, school withdrawal, school exclusion, and broader school attendance problems. This…
Predicting multiple mental health outcomes in adolescents using explainable machine learning models
IntroductionAdolescent mental health problems, including depression, anxiety, and stress, are an increasing public health concern, yet the factors associated with different mental health outcomes may vary across domains. This study investigated shared and outcome-specific predictive features of depression, anxiety, perceived…
Resting-state frontal theta/beta ratio and psychological symptoms in college students: an EEG study
BackgroundMental health problems are increasingly prevalent among college students and represent an important public health concern. Neurophysiological indicators derived from electroencephalography (EEG) may provide objective markers for identifying psychological vulnerability. The theta/beta ratio (TBR) has been widely associated with attentional…
How genes shape personality and experience
Nature Medicine, Published online: 18 September 2026; doi:10.1038/d41591-026-00046-yA genome-wide association study involving over one million people reveals genetic contributions to personality traits, with potential causal effects on physical and mental health and behaviors.
Interventional rTMS for Improving Social Perception in Autism
Conditions: Autism Spectrum Disorders (ASD) Interventions: Device: Neuromodulation by transcranial magnetic stimulation (TMS); Radiation: Anatomo-functional MRI; Device: Eye-tracking; Other: Social Responsiveness Scale, Second Edition (SRS-2) Sponsors: Assistance Publique - Hôpitaux de Paris; URC-CIC Paris Descartes Necker Cochin Not yet recruiting
The BRAVE (Behaviourally Responsive Assessments of Vital Signs in Emergency) Study
Conditions: Autism Spectrum Disorder Interventions: Device: wearable vital sign device Sponsors: Hamilton Health Sciences Corporation Not yet recruiting
Dual-task standing in older adults with mild cognitive impairment: postural control complexity, prefrontal activation, and cognitive task performance
BackgroundThis study aimed to quantify prefrontal cortex (PFC) activation and postural control complexity in older adults with mild cognitive impairment (MCI) during single-task standing and dual-task standing balance conditions and to investigate the associations between these measures.MethodsThis secondary analysis included…
Daytime lighting conditions alter home-cage behavior across both sexes in diurnal grass rats
Circadian rhythms are crucial to biological functions, and cognitive functions such as attention, choice, and preference-related behaviors are modulated by circadian rhythms and disrupted in mood disorders such as Seasonal Affective Disorder (SAD) and Major Depressive Disorder (MDD). These neuropsychiatric…