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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Phenotype, Genetics, and Interpretation: Further Considerations on Atypical Depression
We read with great interest the recent article by Shin et al. (1). The authors leveraged the substantial Australian Genetics of Depression Study (AGDS) cohort to provide compelling evidence for the clinical and biological validity of the atypical depression subtype.…
Comorbidity alters the genetic relationship between anxiety disorders and major depression
The extensive genetic overlap between anxiety disorders (ANX) and major depression (MD) may partly reflect inclusion of comorbid cases in genome-wide association studies (GWAS). We investigated this genetic relationship between ANX and MD with and without mutual comorbidity.
What Is Traumatic Separation?
You may have a memory of being separated from a parent when you were a child, even just for a few minutes. Maybe you lost them in a crowd or wandered a little too far at the store and felt…
Two-year longitudinal neuropsychological monitoring after unilateral and staged bilateral subthalamic nucleus deep brain stimulation
IntroductionDeep brain stimulation (DBS) is an increasingly popular therapeutic method for treating motor symptoms in Parkinson’s disease, but its impact on non-motor symptoms in long-term follow-up remains debated.MethodThe primary objective of this study was to monitor the cognitive functioning, mood,…
Can exercise combined with transcranial direct current stimulation improve cognitive function in older adults? A systematic review and meta-analysis
ObjectiveThis study investigated whether combining exercise with transcranial direct current stimulation (tDCS) improves overall cognition, memory, and executive function in older adults.MethodsFollowing PRISMA guidelines, we systematically searched databases including PubMed, Web of Science, CNKI, and Wan Fang for randomized controlled…
Computer-based tree drawing test in adolescents and adults with depression
ObjectiveTo evaluate the value of the computer-based Tree Drawing Test in the auxiliary diagnosis of depressive disorders and to analyze the differences in the performance of adolescent and adult depression patients in the Tree Drawing Projection Test.MethodsThis study was conducted…
Extended Group Written Exposure Therapy for Comorbid PTSD and BPD (Traits)
Conditions: Posttraumatic Stress Disorder (PTSD); Borderline Personality Disorder (BPD) Interventions: Behavioral: Group Written Exposure Therapy Sponsors: St. Joseph's Healthcare Hamilton Not yet recruiting
Reestablishing Normal Gut-brain Interaction in Anorexia Nervose With Normal Gut Microbiota
Conditions: Anorexia Nervosa Interventions: Biological: Psychotherapy as usual combined with single dose normal gut microbiota; Other: Psychotherapy treatment as usual (TAU) Sponsors: Haukeland University Hospital; The Dam Foundation Not yet recruiting
Barriers and Facilitators in the Implementation of the Systematic Medical Appraisal, Referral, and Treatment (SMART) Mental Health Digital Intervention in Rural India: Mixed Methods Process Evaluation Study
Background: An estimated 150 million people have mental health care needs in India, but only 15% are able to access care. Depression and anxiety contribute to a large proportion of mental morbidity. The Systematic Medical Appraisal, Referral, and Treatment (SMART)…
Digital Therapeutic Content for Substance Use Disorder Treatment: Development and Evaluation Study
Background: Substance use disorders (SUDs) are a major public health concern, contributing to significant individual and societal costs. Despite this, the uptake of evidence-based pharmacologic and behavioral interventions remains limited. The digital delivery of SUD treatment has emerged as a…
Oral Small-Molecule GLP-1s Linked to Deep Brain Activity and Reduced Cravings in Mice
New findings in mice suggest that oral small-molecule GLP-1 drugs may directly influence deep brain pathways involved in desire, revealing how these therapies reduce cravings and food-seeking behavior. The post Oral Small-Molecule GLP-1s Linked to Deep Brain Activity and Reduced…
Autism Screening Proposed for Children with Epilepsy
Children with epilepsy should be screened for developmental concerns, following a study suggesting they are up to 10 times more likely than others to have autism. The post Autism Screening Proposed for Children with Epilepsy appeared first on Inside Precision…
PMAT enhances sexual dimorphism of fear behaviors and facilitates female mice’s generalized contextual fear extinction
Enhanced signaling of dopamine and/or serotonin during highly arousing situations can be reduced in part by monoamine transporters, such as plasma membrane monoamine transporter (PMAT, Slc29a4). An absence of selective pharmacological inhibitors means genetically modified mice constitutively deficient in PMAT…
Identifying clinical features associated with electroconvulsive therapy response in adolescents with major depressive disorder using machine learning
BackgroundElectroconvulsive therapy (ECT) is an effective treatment for adolescent major depressive disorder (MDD), but its efficacy varies. This study utilized machine learning (ML) to identify baseline clinical factors associated with poor ECT response.MethodsWe retrospectively enrolled 503 adolescent MDD patients. A…
A two-decade bibliometric analysis (2004–2024) of parental factors in the context of internet gaming disorder research
ObjectiveThis is the first targeted bibliometric analysis which explores the development of scientific production on the relationship between parenting and Internet Gaming Disorder (IGD) over twenty years, emphasizing the central role of the family context in the etiology and maintenance…
[Articles] Who receives psychiatry-focused pharmacogenomic testing, and is it associated with prescribing patterns and acute care utilisation in depression? Real-world evidence from a large health system
In routine clinical practice, PGx testing is preferentially used in youth and adults with clinically complex histories and is associated with shifts in antidepressant prescribing patterns. Exploratory findings suggest hypothesis-generating signals of reduced psychiatric ED utilisation among patients with higher…
Noise, air pollution exposure and attention-deficit/hyperactivity disorder: a meta-analysis
ObjectiveThis meta-analysis evaluated the associations between noise exposure, air pollutants, and attention-deficit/hyperactivity disorder (ADHD) in children, aiming to inform future prevention strategies.MethodsStudies were systematically retrieved from CNKI, Wanfang, PubMed, Web of Science, Embase, and the Cochrane Library, covering publications from…
At-Home Blood Test Screens for Early Dementia
A simple, at-home blood test used together with online cognitive tests can spot early dementia, identifying people at greatest risk and potentially acting as a useful triage resource in remote settings. The post At-Home Blood Test Screens for Early Dementia…