Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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A Co-Designed and Bilingual WhatsApp-Based Chatbot Intervention (PflegeBot) for Informal Caregivers in Germany: Single-Arm Nonrandomized Feasibility Study
Background: Informal caregivers play a central role in long-term care but experience elevated risks of stress, depressive symptoms, and caregiver burden, alongside barriers to accessing preventive support. Low-threshold digital public health interventions may offer scalable support; however, evidence on their…
Depression Screening Positivity, Treatment-Seeking Intention, and Willingness to Take Antidepressants in a Self-Selected Online Sample of Korean Adults: Cross-Sectional Questionnaire Study
Background: Depression is a prevalent psychiatric condition with functional and socioeconomic consequences. Understanding the barriers to professional help-seeking and treatment acceptance among individuals with depressive symptoms is important. Objective: This study aimed to quantify depression screening positivity and examine treatment-seeking…
An Online Cross-Sectional Research Domain Criteria (RDoC) Positive Valence Assessment Study With Patients With a Severe Mental Illness: Methodological Evaluation
Background: Abnormal reward processing is considered a core feature of severe mental illness (SMI). Deficits in this domain can have severe implications for daily functioning. The Online Positive Valence Study aimed to assess reward processing in bipolar disorder and schizophrenia…
Examining the Feasibility, Acceptability, and Preliminary Efficacy of a Health App for Postacute Pandemic Years in Managing Physical and Psychological Distress Symptoms: Pilot Quasi-Experimental Study
Background: Physical and psychological distress symptoms can adversely affect daily functioning and quality of life, highlighting the need for accessible self-management support. Although mobile health (mHealth) interventions show promise in supporting physical symptom management, evidence regarding their feasibility and potential…
Psychosocial Correlates of AI Chatbot Use for Emotional Support Among Young Adults: Cross-Sectional Study
Background: Generative AI chatbots are increasingly used for mental health–related purposes, yet little is known about the factors associated with such use or AI chatbot dependence. Objective: This study examined factors associated with young adults’ use of AI chatbots for…
Efficacy of mindfulness-based interventions and biofeedback for migraine management: a systematic review and meta-analysis of randomized controlled trials
ObjectiveThis systematic review and meta-analysis of randomized controlled trials aims to analyze the efficacy of mindfulness-based interventions and biofeedback on headache frequency, pain intensity, headache-related disability, psychological distress, and quality of life in adult patients with migraine.MethodsThe review followed the…
What Is Sextortion?
Andy, a 16-year-old high school junior in New York City, received a message from a girl he didn’t know on Snapchat. She was cute, blonde, a freshman at the University of Wisconsin, and her greeting was Midwestern nice. He barely…
AI-Derived Emotional States and Trajectories in Real-World Mental Health Sessions: Large-Scale Observational Study
Background: AI-powered digital mental health interventions (DMHIs) are increasingly deployed to support employee mental health, yet evaluations have focused predominantly on pretest-posttest symptom outcomes. The emotional states that unfold within real-world AI-assisted sessions remain largely uncharacterized, limiting understanding of how…
Renewing a Commitment to Collaboration
Ottawa ON, November 10, 2026 — The Canadian Centre on Substance Use and Addiction and the Mental Health Commission of Canada signed a renewed memorandum of understanding on November 9, 2026, issuing the following joint statement: “The Canadian Centre on…
Maladaptive state allocation: an orexin-based framework linking sleep disturbance, chronic pain, and substance use disorder
Sleep disturbance, chronic pain, and substance use disorders are highly prevalent conditions that frequently co-occur and exacerbate one another. Although traditionally studied as distinct clinical entities, growing evidence suggests they share common neurobiological mechanisms. Among these, the orexin (OX; also…
Associations between insomnia and suicidal ideation in depressed adolescents: the mediating effect of cognitive symptoms and sex differences
BackgroundAmong adolescents diagnosed with major depressive disorder (MDD), suicidal ideation (SI) may be closely linked to cognitive symptoms and insomnia. However, the potential pathways connecting these three factors remain unclear. This study aimed to systematically investigate the mediating role of…
Network analysis of the association between alexithymia and cognitive-emotional regulation strategies in nursing students with non-suicidal self-injury: a gender difference perspective
BackgroundNon-suicidal self-injury (NSSI) is prevalent among nursing students and closely linked to alexithymia and emotional dysregulation. However, conventional total-score analyses treat alexithymia and cognitive emotion regulation strategies (CERS) as unitary constructs, obscuring dimensional associations across multiple strategies. Network analysis overcomes…
Perceived stress, occupational burnout, and anxiety among PIVAS healthcare professionals: the moderating role of research competence
BackgroundPharmacy Intravenous Admixture Services (PIVAS) are now an integral part of patient care in modern hospitals. However, personnel working in PIVAS are often exposed to intense perceived stress, making them more susceptible to occupational burnout and anxiety, which may negatively…
Mentalization Orientated Psychoeducation Group for Adult ADHD (MOPAD)
Conditions: ADHD - Attention Deficit Disorder With Hyperactivity Interventions: Behavioral: The MOPAD study tests whether an introductory Mentalization-Based Treatment (iMBT) Sponsors: Surrey and Borders Partnership NHS Foundation Trust Not yet recruiting
Sex-specific motivations, risk perceptions, and E-cigarette experimentation among adolescents and young adults: implications of public health intervention
IntroductionElectronic cigarette (EC) use is growing exponentially among adolescents and young adults, alongside mental health challenges. In Mexico, despite a strict sales ban in effect in 2024, consumption remains a critical issue. This study evaluated EC and other substance use…
Correction: Smartphone App–Delivered Mindfulness-Based Intervention for Concussion in Adolescents (MBI-4-mTBI): Feasibility Randomized Controlled Trial
Addendum: Smartphone App–Delivered Mindfulness-Based Intervention for Concussion in Adolescents (MBI-4-mTBI): Feasibility Randomized Controlled Trial In response to the published article by Sicard et al. (doi: 10.2196/84623) in JMIR Rehabilitation and Assistive Technologies, we would like to correct the following errors…
Engagement, Feasibility, and Perceived Alliance With a Large Language Model–Enabled Mental Health Voice and Chatbot: Exploratory Longitudinal Observational Study
Background: Conversational AI systems are increasingly used for web-based mental health support, yet evidence on sustained engagement, therapeutic alliance, and longitudinal outcomes remains limited. Baseline data from 527 self-referred users of the large language model–enabled chatbot Clare indicated high psychological…
Technology-Integrated Art Therapy: Scoping Review of Outcomes and Processes
Background: The rapid integration of digital technologies into art therapy reflects both technological advances and the growing need for flexible, accessible mental health care. Objective: This scoping review aimed to systematically map and synthesize empirical research in English on technology-integrated…
The Best Kids’ Books About Mental Health of 2026
Children’s books about mental health can help young readers understand emotions, learn about their (or a friend’s) diagnosis, and build resilience. It seems like there’s a book for nearly any topic, from OCD, anxiety, or autism to body image, grief,…
Psychometric evaluation of the Korean version of the social stigmatization scale with preliminary longitudinal evidence for psychological distress among young adults
BackgroundThe mental health of young adults in South Korea has become a significant social issue. In the context of South Korea’s competitive and hierarchical society, social stigma—defined as a devalued social identity shaped by cultural beliefs that label certain attributes…