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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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AI Tool Helps Link BRSK1 Variants to Neurodevelopmental Disorder
AI-assisted genomic analysis was combined with human genetics and fruit fly experiments to link reduced BRSK1 function to a variable neurodevelopmental disorder. The post AI Tool Helps Link BRSK1 Variants to Neurodevelopmental Disorder appeared first on GEN - Genetic Engineering…
Association of temporal and masseter muscle thickness with cognitive function and clinical severity in Alzheimer’s disease: a retrospective study
BackgroundTemporal muscle thickness (TMT) has emerged as an imaging marker of skeletal muscle status and may be associated with cognitive decline in Alzheimer’s disease (AD). However, its relationship with AD severity remains unclear, and the clinical relevance of masseter muscle…
Trait, state, and behavior in adolescent NSSI addiction: a serial mediation model linking childhood trauma to NSSI addiction
BackgroundDespite growing recognition of non-suicidal self-injury (NSSI) as a potential behavioral addiction, the sequential mechanisms linking childhood trauma to NSSI addiction remain unclear. This study examined a serial mediation model testing whether trait impulsivity and depressive symptoms sequentially mediate this…
Adolescent non-suicidal self-injury scale – short form: revision and evaluation of its reliability and validity
ObjectiveNon-suicidal self-injury (NSSI) is a clinically significant concern among adolescents, and its accurate yet efficient assessment is essential for research, early identification, and intervention. Existing Chinese instruments—most notably the 19-item Adolescent Self-Harm Questionnaire (ASHS)—are relatively lengthy and ill-suited to rapid,…
The chain-mediating effect of societal pressure on appearance and body image on fear of negative evaluation and social anxiety in women with polycystic ovary syndrome: a cross-lagged panel analysis
Objective(Prospective Longitudinal Observational Study) This study aimed to examine the longitudinal chain mediating roles of physical appearance social pressure and body image in the relationship between fear of negative evaluation (FNE) and social anxiety among women with polycystic ovary syndrome…
Effect of age-friendly community degree on the cognitive function of older adults
IntroductionThe relationship between individual environmental indicators and the physical and mental health of older adults has been widely studied. However, the holistic impact of age-friendly communities on the wellbeing of older adults has not beenclearly elucidated. This study aimed to…
Pilot clinical study of Taxifolin Aqua effect in patients with amnestic mild cognitive impairment
Taxifolin (dihydroquercetin), a potent antioxidant flavonoid, shows promise for neurodegenerative conditions. Our pilot study aimed at evaluation the efficacy and safety of Taxifolin in patients with amnestic mild cognitive impairment (aMCI) and monitored a set of blood measures. Twenty-three patients…
Methodology of Super-Early Training of Developer Engineers and Leading Analysts With a Diagnosis of ADHD/ASD for Ensuring the Engineering Sovereignty of the State: Time Horizon: 2026-2038-2050
Conditions: Attention Deficit Hyperactivity Disorder (ADHD) Interventions: Device: Voice of Sleep "MamaBee" training modules (Fairy Tales) Sponsors: Pisareva Citadel Group LLC Active, not recruiting
Routine Online Psychological Therapy in an Insurance-Based Care Setting: Retrospective Service Evaluation of Real-World Outcomes
Background: Depression, anxiety, and stress-related difficulties represent a major global health burden. Online psychological therapy has emerged as a promising approach to increasing access to care, yet evidence from routine, real-world clinical settings, particularly for services delivered without standardized treatment…
Perinatal Mental Health Detection and Prediction Using Mobile Sensing Data: Systematic Review
Background: Perinatal mental health disorders affect approximately 20% of pregnant and postpartum individuals, and are associated with substantial maternal and infant morbidity. Traditional assessment relies on infrequent, subjective self-reports. Mobile devices, including smartphones and wearables, offer opportunities for continuous and…
Possible Role and Function of AI Conversational Agents in Dialectical Behavior Therapy for Borderline Personality Disorder: Qualitative Interview Study
Background: Borderline personality disorder (BPD) is associated with substantial distress and a high risk for suicide. Individuals with BPD may be unable to access evidence-based treatments like dialectical behavior therapy (DBT). Artificial intelligence conversational agents (AI-CA) are increasingly discussed as…
Assessing the Need for Mental Health Support From Free-Text Responses: Development and Validation of Language-Based Assessments in Adults With Internalizing Symptoms
Background: Machine learning and natural language processing have demonstrated significant potential for mental health assessment: describing your mental health in your own words can offer a more ecologically valid approach than traditional rating scales. However, most models focus on specific…
Biological hierarchy from genotype to phenotype in syndromic and non-syndromic autism spectrum disorder
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition whose pathophysiology is thought to arise from complex interactions among genetic variation, molecular and cellular perturbations, and neural circuit dysfunction. Although the distinction between syndromic and non-syndromic ASD was introduced as…
Non-motor correlates of anxiety in de novo Parkinson’s disease: a cross-sectional study with exploratory subgroup analyses
ObjectiveAnxiety is a prevalent early non-motor symptom of Parkinson’s disease (PD), but its clinical correlates remain poorly defined in de novo, drug-naïve patients. This retrospective cross-sectional study enrolled 284 medication-naïve de novo PD patients and 147 age- and sex-matched healthy…
Metabolic dysfunction associates with neuroimaging measures of brain structure and connectivity
IntroductionMetabolic syndrome (MetS) and insulin resistance are established risk factors for Alzheimer’s disease (AD) and have been linked to alterations in brain structure and function, including within the Default Mode Network (DMN).MethodsHere, we examined associations between metabolic dysfunction, brain structure,…
Trauma-informed psychological support alongside long-acting injectable buprenorphine: clients’ perspectives on the Buvidal psychological support service (BPSS) pilot in Wales
BackgroundOpioid use disorder (OUD) is associated with persistent drug use, high relapse rates, and significant morbidity, mortality, and psychosocial harm. While Long-Acting Injectable Buprenorphine (LAIB), marketed as Buvidal, offers improved pharmacological management over traditional opioid substitution therapy (OST), the mental…
Emotional maltreatment and problematic short-video use among adolescents: an indirect association through narcissism and moderation of the direct association by physical activity
IntroductionEmotional maltreatment has been associated with problematic short-video use during adolescence, but the nature of this association remains unclear. This cross-sectional study examined the association between emotional maltreatment and problematic short-video use, estimated the indirect statistical association through narcissism, and…
Factors associated with school absenteeism in adolescents with mental illness: a multivariate analysis
Backgroundschool absenteeism is a common functional impairment among adolescents with mental disorders, yet its associated factors remain limited. This study aimed to identify key demographic, clinical, and social factors associated with school absenteeism in this population.MethodsA retrospective cohort study was…