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468 results

Tags: Biomarker, Reality testing and perceptual stability, Schizophrenia spectrum

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Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN)

Conditions: Severe Mental Illness; Depression / Major Depressive Disorder; Bipolar Disorder (BD); Schizophrenia Interventions: Drug: Semaglutide (SEMA); Behavioral: Exercise module; Behavioral: Anti-inflammatory diet module; Behavioral: Sleep intervention module; Behavioral: Social prescribing module; Device: Closed-loop transcranial alternating current stimulation (CL-tACS); Behavioral:…

Tags: Appetite and ingestive regulation, Bipolar, Depression, Germany, Medical device, Mental health, Mood and emotional regulation, Psychoeducation program

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Factors Influencing the Initiation and Continued Engagement of Digital Mental Health Tools Among Adults: Theory of Planned Behavior–Informed Systematic Review

Background: Digital mental health tools (DMHTs) offer scalable support, but engagement varies. Understanding the shapes of initiation and ongoing use is essential for effective design and implementation. Objective: This study aims to synthesize determinants of adults’ initiation and engagement with…

Tags: Academic research, Medical device, Mental health, Social and attachment drive

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Reducing Intrusive Trauma Memories Using a Brief Mental Imagery Competing Task Intervention: Case Series of Trauma-Exposed Women in Iceland

Background: There is a need for scalable and simple interventions for trauma-exposed people. In this case series, we built on our previous case study and case series findings and further explored the use and potential effectiveness of a brief novel…

Tags: Academic research, Anxiety, Clinical trial, Depression, Mental health, Mood and emotional regulation

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Large Language Models and Their Applications in Mental Health: Scoping Review

Background: Large language models (LLMs) are poised to transform mental health care, offering advanced capabilities in diagnosis, prognosis, and decision support. Since their inception, numerous mental health-focused LLMs have emerged in the scientific literature, reflecting the growing interest in leveraging…

Tags: Academic research, Depression, Mental health, Mood and emotional regulation

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Tags: Academic research, Reality testing and perceptual stability, Schizophrenia spectrum

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A hierarchical machine learning model for predicting self-harm and suicidal behaviour in hospitalised patients with schizophrenia using clinical history and nursing observations

ObjectiveThis study aimed to develop and evaluate a two-layered machine learning framework that combines admission clinical information with longitudinal nursing observations to identify schizophrenia inpatients at high risk of self-harm or suicidal acts.MethodsWe retrospectively reviewed the records of 477 patients…

Tags: Academic research, Depression, Mood and emotional regulation, Schizophrenia spectrum, Sleep and arousal regulation

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Context-dependent interaction between oxytocin gene polymorphisms and alcohol dependence in modulating negative emotions during acute alcohol withdrawal in adult males

ObjectiveThe importance of multiple gene-environment interaction (G × E) has been highlighted in understanding the etiology of negative emotions. This study examines the impact of oxytocin (OXT) polymorphisms (rs2740210, rs6133010, and rs2740209) in combination with alcohol dependence on anxiety and…

Tags: Academic research, Anxiety, Depression, Mood and emotional regulation, Social and attachment drive, Substance abuse, Substance use

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Validation of a criterion-based screening and triage pathway for adult ADHD: a prospective observational study of safety and operational efficiency

BackgroundThe increasing demand for adult attention-deficit hyperactivity disorder (ADHD) assessments has required the development of efficient triage pathways. This study provides a formal assessment of a criterion-based screening model designed to prioritise patient safety and operational efficiency within a National…

Tags: Academic research, ADHD, Cognitive focus and executive control, Healthcare provider, United Kingdom

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Parsing autism spectrum heterogeneity through fMRI

Nature Neuroscience, Published online: 15 May 2026; doi:10.1038/s41593-026-02269-1Autism is remarkably heterogeneous, posing a long-standing challenge for linking genetics to brain dynamics. A cross-species study identifies two principal dysconnectivity signatures across 20 mouse models of autism risk, each associated with distinct…

Tags: Academic research, Autism

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Acupuncture Treament in Children With Tic Disorders

Conditions: Tic Disorder, Childhood Interventions: Other: Acupuncture; Behavioral: Comprehensive Behavioral Intervention for Tics (CBIT) Sponsors: Meizhou People's Hospital Not yet recruiting

Tags: Healthcare provider, Motor and impulse regulation, Tic & Tourette

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Family psychoeducation to support patients with psychotic illness: two-year outcomes from a pre–post longitudinal pilot study

BackgroundPsychoeducation for families of young adults with psychosis is an evidence-based intervention that alleviates carer burden. The implementation of programming is limited, leaving family carers shouldering a heavy burden without appropriate support.ObjectiveThis pre-post longitudinal pilot study evaluated the preliminary outcomes…

Tags: Academic research, Canada, Psychoeducation program, Reality testing and perceptual stability, Schizophrenia spectrum

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[Comment] How much is enough in ADHD pharmacotherapy?

The evidence base for ADHD pharmacotherapy has answered one question more confidently than any other: whether medications are effective, on average, in reducing core ADHD symptoms. We know that several stimulant and non-stimulant treatments, including methylphenidate, amphetamines, atomoxetine, and guanfacine,…

Tags: ADHD, Medication

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