Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Implementation Strategies for a Technology-Based Bullying Bystander Intervention (STAC-T): Mixed Methods Study
Background: Nearly 1 in 5 students aged 12-18 years report being bullied in the United States. Both targets and students who witness bullying experience negative mental health outcomes. School-based programs are effective in decreasing negative outcomes associated with bullying; however,…
Clinimetric properties of the Chinese version of the subjective incompetence scale: an extended paradigm
ObjectivesThis is the first validation study to evaluate the measurement properties (i.e., construct, concurrent, incremental, and relative validity) and determine the clinical utility of the Chinese version of the 12-item subjective incompetence scale (SIS-12) based on the science of clinimetrics.MethodsConsecutive…
Association between platelet-to-albumin ratio and major depressive disorder: findings from a Chinese clinical cohort supported by population-based evidence
BackgroundPlatelet dysfunction has been increasingly implicated in the pathophysiology of major depressive disorder (MDD), yet conventional platelet indices have shown inconsistent associations with the disease. The platelet-to-albumin ratio (PAR), a composite biomarker integrating inflammatory and nutritional status, has not been…
Depression in autism spectrum disorder: a scoping review of pharmacologic, neuromodulation, and psychosocial interventions
IntroductionMajor depressive disorder is common in autism spectrum disorder, but diagnosis and treatment are complicated by symptom overlap, atypical presentations, alexithymia, and limited ASD-specific evidence.MethodsWe conducted a scoping review of PubMed, PsycINFO, and reference lists for studies published from 1995…
Integrated bioinformatics analysis identifies a ubiquitination-related gene signature in schizophrenia with peripheral clinical validation
BackgroundDysregulation of the ubiquitin proteasome pathway is implicated in the pathogenesis of schizophrenia (SCZ). The objective of this study is to identify the dysregulation of the ubiquitin-proteasome pathway and the potential mechanisms associated with SCZ by comprehensive analysis using integrated…
Longitudinal trajectories of benefit finding and its associations with emotion regulation, social connectedness, depression, and anxiety among Chinese college students following the removal of COVID-19 restrictions. a multivariate latent growth curve analysis
BackgroundBenefit finding may be associated with better mental health after the pandemic, but its longitudinal trajectory and its associations with psychosocial resources and mental health symptoms during recovery remain unclear.ObjectiveThis study examined trajectories of benefit finding among Chinese college students…
Effectiveness of the Autism Pupil Screen (APS) Detect Pupillometer for Identifying Autism Spectrum Disorder (ASD) in Routine Healthcare
Conditions: Autism Spectrum Disorder Interventions: Device: Autism Pupil Screen (APS) Detect PLR Assessment #1; Other: Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT/R-F); Other: Social Responsiveness Scale, Second Edition (SRS-2); Diagnostic Test: Autism Diagnostic Observation Schedule, Second Edition…
Evaluation of a Novel Quantum-Inspired Intervention (QII) for Children With Autism Spectrum Disorder: A Global Confirmatory Study
Conditions: Autism Spectrum Disorder; Autism Spectrum Disorder (ASD; ASD Interventions: Other: Quantum-Inspired Intervention (QII) Sponsors: BlissBot, Inc Not yet recruiting
Connectedness as a candidate pathway linking psilocybin retreat experiences to sustained wellbeing: a prospective naturalistic study
BackgroundPsychedelic retreats are increasingly used to promote wellbeing outside clinical settings, yet the psychological processes associated with sustained improvements in wellbeing remain poorly understood. From a public mental health perspective, identifying mechanisms that support positive mental health beyond symptom reduction…
Pediatric psychotropic prescribing and polypharmacy, 2019-2022: a retrospective electronic health record study in Qatar
BackgroundReal-world evidence on pediatric psychotropic prescribing and polypharmacy in Gulf health systems remains limited. Characterizing medication-class patterns and multi-class prescribing is essential for medication safety surveillance in children and adolescents. This study examined psychotropic prescribing, potential polypharmacy, and recorded medication…
Social Media Use Motives and Mental Health Among Adolescents: Cross-Sectional Study
Background: Social media use is ubiquitous among young people, yet its relationship with mental health may depend on why it is used. Understanding the motives underlying social media engagement may provide greater insights into its potential risks and benefits than…
Psychosocial distress is a stronger correlate of psychiatric symptom burden than cannabis dependence in young adults: a functional connectome and structural equation modeling study
IntroductionCannabis is widely used among young adults and often viewed as a primary driver of adverse psychiatric and neural outcomes, yet the psychosocial and socioeconomic context in which use occurs is rarely modeled jointly with neural and behavioral measures.MethodsUsing the…
Nogo-related frontal theta-band activity after magnetic seizure therapy in treatment-resistant depression: an exploratory task-based EEG study
IntroductionMagnetic seizure therapy (MST) is an emerging convulsive treatment for treatment-resistant depression (TRD) with efficacy comparable to electroconvulsive therapy and superior cognitive safety. However, its neurophysiological mechanisms—particularly those underlying conflict monitoring and response inhibition—remain unclear. Frontal midline theta-band activity indexes…
Impulsivity is the principal correlate of problematic internet use in young adults with attention-deficit/hyperactivity disorder: a cross-sectional clinical study
IntroductionAttention-deficit/hyperactivity disorder (ADHD) and problematic internet use share clinical features such as impulsivity, emotional dysregulation and impaired inhibitory control, but most evidence comes from children, adolescents and non-clinical samples. It remains unclear which dimension carries this association in adults with…
Latent profiles of day-7 cognitive performance and associated ecological factors in older adults after elective surgery: an observational study
ObjectiveTo identify latent profiles of postoperative day-7 cognitive performance among older adults after elective surgery and to explore demographic, behavioral, clinical, and social factors associated with profile membership.MethodsThis prospective observational study included 308 consecutively recruited patients aged ≥65 years who…
Dance- and movement-based interventions for autism spectrum disorder: a systematic review and exploratory meta-analysis
ObjectivesAutism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by difficulties in social communication, restricted and repetitive behaviors, and impaired adaptive functioning. Although behavioral and developmental interventions remain central to ASD management, the effects of dance- and movement-based interventions…
Trajectories of perinatal depression, anxiety, perceived stress, sleep quality, and psychological flexibility from pregnancy to six months postpartum and their relationship with the number of abortions and deliveries
BackgroundPerinatal psychological distress is common and longitudinally heterogeneous, yet little is known about how obstetric history shapes symptom trajectories. We identified trajectories of depressive symptoms, perceived stress, sleep quality, psychological flexibility, and anxiety from early pregnancy to 24 weeks postpartum…
Multimodal Biomarkers Predicting Medication-Induced Adverse Effects in Children With ADHD
Conditions: ADHD Interventions: Drug: methylphenidate Sponsors: National Taiwan University Hospital Recruiting
Symptom severity at first digital self-assessment is not associated with greater subsequent booking of professional care on a Saudi mental health platform: a cohort study of 5,524 users
BackgroundDigital mental health platforms routinely deliver self-administered symptom scales on the assumption that users with more severe symptoms are more likely to enter professional care. That assumption is rarely tested with linked participant-level data, and almost never in the Arabic-speaking…
Understanding the Different Types of Psychological Evaluations
If your child is struggling with mental health, behavior, or learning challenges, the first step to getting them the support they need is to seek a professional assessment. Whether you’ve been motivated to do so by the child’s teacher, the…