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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Neural encoding of auditory processing in schizophrenia
IntroductionAuditory processing abnormalities are a core feature of schizophrenia and are linked to deficits in speech perception, cognitive function, and everyday communication. It remains unclear which stages of auditory processing are most disrupted and how these disruptions relate to symptoms…
Marital satisfaction and phubbing: the roles of depressive symptoms and subjective social status
BackgroundPrevious studies have mainly examined the associations between partner phubbing and relationship outcomes among phubbees, whereas less is known about how marital relationship quality is associated with phubbing among phubbers themselves. This study aims to examine the relationship between marital…
Association between perceived school climate and employment anxiety among medical undergraduates: the mediating role of intentional self-regulation and the moderating role of perceived employability
BackgroundEmployment anxiety is an important psychological concern for medical undergraduates during the transition from university to work. This study examined the association between perceived school climate and employment anxiety and evaluated the roles of intentional self-regulation and perceived employability in…
Developing Microbiome and Dietary Strategies Based on Chrono-nutrition for Targeting ADHD
Conditions: ADHD; ADHD - Attention Deficit Disorder With Hyperactivity Interventions: Behavioral: Circadian fasting Sponsors: Spanish National Research Council; Hospital Universitario Doctor Peset; Institute of Agrochemistry and Food Technology, National Research Council; State Research Agency, Spain Enrolling by invitation
Breaking the Cycle of Social Media Addiction: Efficacy of a 4-STEP Training Program in Reducing Cognitive Fatigue, Psychological Distress, Academic Procrastination, and Burnout Among Adolescents
Conditions: Social Media Addiction Interventions: Behavioral: 4-STEP-TPS Sponsors: Government College University Faisalabad Not yet recruiting
4-STEP Training Program for Social Media Addiction, Cognitive Fatigue, Psychological Distress, Academic Burnout and Procrastination Among Students
Conditions: Social Media Addiction Interventions: Behavioral: 4-STEP-TPS Sponsors: Government College University Faisalabad Not yet recruiting
Exploration of the relationship between social cognition and PTSD using data from the ALSPAC cohort
Background and hypothesisPrevious studies have shown an association between social cognition (emotion recognition, social perception, attributional style, and mentalization) and post-traumatic stress disorder (PTSD), but there have been no longitudinal studies on this topic. We hypothesize that childhood social cognitive…
Emotion regulation difficulties and experiential avoidance in adolescents with non-suicidal self-injury: a latent profile and moderation analysis
BackgroundNon-suicidal self-injury (NSSI) represents a significant clinical concern among adolescents. Although emotion regulation difficulties (ERD) and experiential avoidance are associated with NSSI, how these regulatory vulnerabilities co-occur within individuals and whether experiential avoidance influences the ERD–NSSI association remain unclear. This…
Improving family functioning and wellbeing among families of children with disabilities in Rwanda: an application of the SAFE child protection model
BackgroundFamilies of children with disabilities in low-resource settings face heightened challenges to family functioning and wellbeing. Improving a child and caregiver’s environment in these settings requires a broader understanding of the family ecosystem. This study aims to investigate factors that…
STAT+: Definium’s LSD therapy eased anxiety in second large trial
The first wave of biotechs is nearing regulatory approval for psychedelic therapies, a class of treatments that appear to exert rapid benefits.
Screening and Monitoring of Mental Health in Educational Settings: Programme for Detection, Psychoeducation and Self-help
Conditions: Anxiety; Depression Disorder; Bullying; Addiction; Suicide; Self Harm; Psychosis; Eating Disorders Interventions: Other: program for the detection, referral, and psychoeducation in adolescents Sponsors: Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; Hospital Universitario Rey Juan Carlos; Hospital Universitario…
Comparisons of the structure and function of higher cortical circuits in marmosets and macaques: Models for mental health disorders
Non-human primates are extremely valuable for neuroscience research due to their strong homology to humans. Marmosets are small, highly social primates, amenable to genetic and circuit manipulations. Macaques, a larger and more aggressive primate, have been the non-human primate model…
Neurophysiological Signatures of Negative Symptom Improvement After High-Definition Transcranial Direct Current Stimulation: A Transcranial Magnetic Stimulation-Electroencephalography Study
Schizophrenia remains a major health challenge, partly because conventional antipsychotics show limited efficacy for negative symptoms. High-definition transcranial direct current stimulation (HD-tDCS) may improve these symptoms, but its neurophysiological mechanisms remain unclear.
Dexamphetamine-induced striatal hyperdopaminergia attenuates reward-related neural activation: A11C-PHNO PET-fMRI study
Ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC) encode the value of stimulus and outcome phases in a context-dependent manner to support motivated behaviour. In psychosis, disrupted motivational coding has been hypothesised to contribute to negative symptoms via reduced sensitivity…
[Corrections] Correction to Lancet Public Health 2026; 11: e506–17
Gustafsson T T, Pauly V, Hamina A, et al. Cause-specific mortality due to physical illness in severe mental disorders in Europe: a population-based multi-country cohort study. Lancet Public Health 2026; 11: e506–17—In this Article, the spelling of Coralie Gandré's name…
[Comment] Relapse or rebound: the case for personalisation in antipsychotic discontinuation
For people with schizophrenia and their psychiatrists, deciding whether to discontinue antipsychotic treatment is a crucial decision. On average, stopping medication roughly doubles relapse risk and increases rates of rehospitalisation and mortality.1,2 However, continued treatment carries its own burden of…
[Editorial] The long walk to antipsychotic availability
The provision of medicines to all patients in need is a worthy goal but one that is rarely met in mental health. A new initiative from MedAccess and the Clinton Health Access Initiative plans to build on successes in disease…
[Comment] Psychodynamic psychotherapy in schizophrenia: where do we stand?
The role of psychodynamic psychotherapy for schizophrenia spectrum disorders has been debated for decades. During the 1960s and 1970s, psychodynamic and psychoanalytical therapies were widely used and were often the main treatment for individuals with schizophrenia-spectrum disorders.1 However, as more…
Altered long-range visual hierarchical connectivity in internet gaming disorder: reduced V1–LOC connectivity and its association with addiction severity
BackgroundNeuroimaging studies of internet gaming disorder (IGD) have primarily focused on reward-related and executive-control networks. However, sensory processing of addiction-related cues, particularly visual processing, may also contribute to IGD. Whether the intrinsic hierarchical organization of the visual system is altered…
Association of Herpes Simplex Virus Type-1 With Dementia Outcomes: Longitudinal Retrospective Cohort Study Using Real-World Electronic Health Record Data
Background: Global dementia cases, currently exceeding 55 million, are projected to triple by 2050. In the absence of disease-modifying therapies, identifying modifiable risk factors is critical. Preclinical studies show that herpes simplex virus type-1 (HSV-1) is neurotropic and can drive…