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Oral administration of kratom leaf extract alleviates anxiety-like behavior, urinary bladder pain, voiding dysfunction, and bladder hypercontractility via attenuating muscarinic receptor response in male mice exposed to chronic water avoidance stress

Psychological stress causes and deteriorates interstitial cystitis/painful bladder syndrome with urinary frequency, incontinence, bladder pain and urgency. The major alkaloid of kratom (Mitragyna speciosa), mitragynine, shows analgesic, anxiolytic, and smooth muscle relaxant effects. However, the effects of kratom leaf extract…

Tags: Academic research, Anxiety, Fear and threat response, Medication

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Tideglusib improves novel object recognition memory in the preclinical DBA/2J mdx mouse model of Duchenne muscular dystrophy

IntroductionDuchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder characterized by progressive muscle wasting. Approximately 1 in 3 DMD patients experience cognitive dysfunction, with research suggesting an Alzheimer’s disease (AD)-like pathology. We have previously shown that treatment with the…

Tags: Academic research, Appetite and ingestive regulation, Medication, Mental health, Reality testing and perceptual stability

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The temporal stability of core symptoms of social media addiction and their comorbidity with anxiety and depression in adolescents: a longitudinal network analysis

IntroductionSocial media addiction (SMA) is often comorbid with anxiety and depression. This study examined the temporal stability of core SMA symptoms and the bridging symptoms with anxiety and depression.MethodsA total of 1,240 adolescents (179 males, 1,061 females; mean age =…

Tags: Academic research, Anxiety, Depression, Mood and emotional regulation, Substance abuse, Substance use

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Psychometric properties of Lithuanian translation of the self-report version of the Liebowitz social anxiety scale in young adult sample

BackgroundSocial anxiety disorder starts in adolescence or young adulthood and may have damaging effects on psychosocial development of the individual. Any intervention starts from assessment and the Liebowitz social anxiety scale with later developed self-report version is a valuable tool…

Tags: Academic research, Anxiety, Fear and threat response

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Effectiveness and mechanisms of Intensive Short-Term Dynamic Psychotherapy for treatment-resistant depression: a reanalysis of a randomized controlled trial

IntroductionIntensive Short-Term Dynamic Psychotherapy has shown promising effects for treatment-resistant depression, but it remains unclear whether its hypothesized mechanisms — reducing emotional repression, negative affect, and psychological distress — actually mediate treatment outcomes.MethodsWe reanalyzed publicly available data from a randomized…

Tags: Chronic depression, Depression, Mood and emotional regulation, Therapy

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Group CBT targeting hostile attribution bias in adolescents and young adults with ASD traits

BackgroundAdolescence is characterized by heightened self-consciousness and sensitivity to social evaluations. During this period, hostile attribution bias—interpreting ambiguous social cues as hostile—can lower quality of life (QOL) and contribute to future mental health problems. Adolescents with autism spectrum disorder (ASD)…

Tags: Academic research, Autism, CBT, Mental health

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Internet addiction among nursing students: application of latent profile analysis and network analysis

BackgroundInternet addiction is widely reported and heterogeneous among nursing students. However, variable-centered approaches may not fully capture profile differences and core symptom patterns, potentially limiting precise interventions. Therefore, identifying distinct profiles and key symptoms is important for informing effective prevention.ObjectiveThis…

Tags: Academic research, Substance abuse, Substance use

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GABA-Based Target for Alzheimer’s Therapy Identified

Modulation of gamma-aminobutyric acid (GABA) signaling can restore disrupted neural balance and improve memory-related function in AD disease models. The post GABA-Based Target for Alzheimer’s Therapy Identified appeared first on Inside Precision Medicine.

Tags: Academic research, Medication, Mental health, Motor and impulse regulation, Reality testing and perceptual stability

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Tags: Reality testing and perceptual stability, Schizophrenia spectrum, Substance abuse, Substance use

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Number of children and maternal mental health in the context of China’s fertility policy transition: the moderating effect of employment status and the mediating effect of family environment

BackgroundHaving more children may be detrimental to maternal mental health during China’s ongoing fertility policy transition. However, under what circumstances and how number of children could be associated with maternal mental health remains understudied in China. This study examined the…

Tags: Academic research, Anxiety, Depression, Mental health, Mood and emotional regulation

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Effect of a nursing-based information–motivation–behavioral model on older patients with type 2 diabetes mellitus

BackgroundOlder patients with type 2 diabetes mellitus (T2DM) frequently encounter challenges, including a diminished capacity for self-management, a high prevalence of negative emotions, and cognitive decline and physiological changes attributable to long-term disease burden, leading to compromised glycemic control and…

Tags: Academic research, Anxiety, Canada, Depression, Mental health, Mood and emotional regulation

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Coping under pressure: police-specific stressors and mental health in Catalonia police forces

IntroductionPolice officers are exposed to elevated psychological risks due to both operational and organizational stressors. Additionally, police officers tend to resort to avoidant coping strategies, which exacerbate poor mental health outcomes, such as burnout and PTSD.MethodsThis study aims to examine…

Tags: Academic research, Anxiety, Depression, Mental health, Mood and emotional regulation

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Iron dyshomeostasis in neuropsychiatric disorders

Iron is an indispensable element for the normal physiological function of the brain. In terms of neuronal metabolism, iron is involved in multiple critical biological processes such as oxygen transport, energy metabolism, DNA synthesis, neurotransmitter synthesis and myelin formation. Maintaining…

Tags: Academic research, ADHD, Autism, Charity / nonprofit, Cognitive focus and executive control, Mental health, Mood and emotional regulation

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Exposure to negative physical and social factors accelerates brain aging

Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04348-zIn a study that included 18,701 people from 34 countries, 73 aggregated physical and social exposomes exhibited nonlinear, synergistic effects that accelerated brain aging. In some cases, these effects were comparable to or…

Tags: Academic research, Medication, Mental health

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MDMA Assisted Therapy for BN

Conditions: Bulimia Nervosa Interventions: Drug: MDMA-AT; Drug: MDMA-AT-BN; Behavioral: Standard Treatment (ST) Sponsors: Icahn School of Medicine at Mount Sinai Not yet recruiting

Tags: Appetite and ingestive regulation, Eating patterns, Medication

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