Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Outcomes of the Integrated Scaling Approach: scaling an evidence-based employment intervention in public mental health systems
Evidence-based practices (EBPs) in supported employment (SE) improve vocational outcomes for individuals with serious mental health conditions, yet their implementation and sustainment at scale remain limited. Thinking Skills for Work (TSW), a cognitive remediation intervention, is an EBP that increases…
Repetitive negative thinking as a transdiagnostic bridge between childhood trauma and depression: Integrating emotion regulation flexibility, stress sensitization, and neurocognitive mechanisms
Childhood trauma is a major risk factor for depression; however, not every affected individual develops clinically significant depressive symptoms. This underscores the importance of identifying transdiagnostic mechanisms that account for vulnerability and resilience. Repetitive negative thinking (RNT), which includes both…
Spatiotemporal remodeling in habenula marks the onset of depression-related phenotypes
Nature Neuroscience, Published online: 19 October 2026; doi:10.1038/s41593-026-02488-6Molina et al. show in chronically stressed mice that neuronal and transcriptional adaptations in the habenula coincide with the onset of depressive phenotype, guiding temporally defined antidepressant interventions.
Adapted Group Therapy Compared With Usual Care for Anxiety and Depression in Adults With an Autism Diagnosis
Conditions: Autism Spectrum Disorder (ASD); Anxiety; Depression Interventions: Behavioral: Autism-adapted group cognitive behavioral therapy Sponsors: Lovisenberg Diakonale Hospital; Helse Sor-Ost Not yet recruiting
Sumud as a framework for collective resilience: a systematic review of implications for transcultural psychiatry and psychotherapy
BackgroundResilience is increasingly understood as a dynamic, ecological process; however, prevailing psychiatric models continue to emphasize individual traits, thereby neglecting collective and culturally embedded forms of endurance. Sumud (Arabic: صمود), broadly translating as steadfastness, perseverance, and endurance, sustains identity, dignity,…
Context presentation and native conversation structure in large language model responses to escalating suicide risk: a controlled multimodel evaluation
BackgroundLarge language models are increasingly used for informal mental health support, yet their safety during escalating suicide-risk conversations may depend on how prior information is presented. Native multi-turn conversations and reconstructed cumulative prompts differ not only in the presence of…
Content, Engagement, and Information Quality of Borderline Personality Disorder Videos on TikTok: Mixed Methods Analysis
Background: TikTok has become a major source of mental health information, yet concerns persist regarding the quality and reliability of psychiatric content disseminated on the platform. While misinformation has been documented for several mental disorders, no study has specifically examined…
Understanding anxiety disorders among Iranian mothers and their children exposed to conflict using an extended transactional model of stress and coping
ObjectiveThe psychological impact of war on families is profound. However, the mechanisms linking war-related stressors to anxiety among mothers and their children remain insufficiently understood, particularly in Middle Eastern contexts. Grounded in an extended transactional model of stress and coping,…
Anxiety and depressive symptoms and health-related quality of life in girls with central precocious puberty versus isolated premature thelarche: a comparative cross-sectional study
IntroductionPrevious studies have examined psychological symptoms and health-related quality of life (HRQoL) in girls with central precocious puberty (CPP) and isolated premature thelarche (IPT), but findings from direct comparisons have been inconsistent. We aimed to compare anxiety and depressive symptoms…
Kamishoyosan reduces anxiety-like behavior by modulating GABAA receptor subunit expression in a premenstrual syndrome rat model
IntroductionPremenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) involve psychological symptoms that impact women’s quality of life. PMS pathogenesis is characterized by fluctuations in steroid hormones and γ-aminobutyric acid type A receptor (GABAAR) subunits. Kamishoyosan (KSS) is a Kampo medicine…
This implant can restore sight for patients with macular degeneration
Age-related macular degeneration (AMD) affects more than 5 million people around the world. And until now, no treatment could restore their vision. The Prima system, which was approved in Europe in July and is awaiting FDA clearance in the US,…
AI-Supported CBT-Based Psychoeducation for Caregivers of Individuals With Schizophrenia
Conditions: Schizophrenia Caregiver; Caregiver Burden; Emotional Expressivity Interventions: Other: Control; Behavioral: Interactive AI-Supported Learning Activities; Behavioral: AI-Supported Cognitive Behavioral Approach-Based Psychoeducation Program Sponsors: Kastamonu University Not yet recruiting
Artificial Intelligence-Powered Virtual Reality Exposure Therapy for OCD in College Students: A Proof-of-Concept Study
Conditions: Obsessive Compulsive Disorder (OCD) Interventions: Other: Traditional Exposure and Response Prevention (ERP); Device: Artificial Intelligence-Powered Virtual Reality Exposure Therapy (AI-VRET) Sponsors: University of California, San Diego Not yet recruiting
Supporting Older Adults Remotely
Conditions: Severe Mental Illness Interventions: Behavioral: Supporting Older Adults Remotely (SOAR); Behavioral: Peer support as usual Sponsors: Dartmouth-Hitchcock Medical Center; National Institute of Mental Health (NIMH) Not yet recruiting
Understanding the Influence of Substance Use, Mental Health, and Stigma on Smoking Behavior Among People Living With HIV: Rapid Qualitative Analysis
Background: In Vietnam, an upper-middle-income country, the majority of people living with HIV smoke. Vietnam has established quitline services to support this population, but they remain underused. Text messaging is widely used in Vietnam, and studies in other countries have…
App-Based Stabilization Phase Within Blended Trauma-Focused Cognitive Behavioral Therapy With Compassion for Adolescents With Posttraumatic Stress Disorder: Formative Qualitative Study
Background: Digital tools may support early phases of trauma therapy for adolescents, yet little is known about how an app-based stabilization phase functions in routine child and adolescent psychiatry clinics. To our knowledge, no previous study has qualitatively examined a…
A Digital Tool for Culturally Responsive Reflection and Case Conceptualization in First-Line Services to Support Children With a Refugee Background: Development and Usability Study
Background: In 2023, over 117 million people were forcibly displaced worldwide, 40% of them children. Refugee children are at higher risk for posttraumatic stress disorder, depression, and anxiety, while professionals may struggle to address mental health and trauma-related concerns across…
Child and Adolescent Mental Health Misinformation on TikTok: Cross-Sectional Mixed Methods Study
Background: TikTok is an important source of mental health information for children, adolescents, and young adults, but the accuracy of psychoeducational content remains uncertain. Misleading information may be particularly consequential for younger users, who may have limited digital and health…
Newly Identified Microexons Offer Clues to Autism Spectrum Disorder’s Genetic Roots
Hundreds of newly identified microexons seem to matter for autism and other neurological conditions, according to a Nature study. A machine learning model of their regulatory code also pinpoints variants predicted to disrupt their splicing in autistic individuals. The post…
Redox compromise as an early, modifiable entry point in schizophrenia: a staging framework for early intervention
Schizophrenia is understood as a disorder of dopamine signaling and is treated with dopamine receptor antagonists. These drugs reduce hallucinations and delusions but leave cognitive impairment, negative symptoms and functional decline largely untouched. This article advances a complementary view, as…