Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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A Neuropsychobiological Approach to Optimize Patient Selection for GLP-1-based Pharmacotherapy for Weight Management Across the Binge Eating Spectrum
Conditions: Obesity & Overweight Interventions: Drug: Semaglutide 3,2 mg/ml Sponsors: Universitaire Ziekenhuizen KU Leuven Recruiting
The Study is Investigating the Effectiveness of the Traditional Islamically Integrated Psychotherapy Using the Islamic Workbook for Religious OCD in Turkish Adults Who Suffer From Scrupulosity.
Conditions: Obsessive - Compulsive Disorder Interventions: Behavioral: Islamically integrated cognitive behavioral intervention Sponsors: Ibn Haldun University Completed
A Digital Mindfulness-Based Program for OCD
Conditions: Obsessive-Compulsive Disorder (OCD) Interventions: Behavioral: Mindfulness-based cognitive-behavioral therapy digital program Sponsors: Unidade Local de Saúde de Coimbra, EPE; University of Coimbra; Coimbra Institute for Clinical and Biomedical Research; Institute of Psychological Medicine (IPM) of the Faculty of Medicine; CIBIT…
Efficacy of stem cell-derived extracellular vesicles in animal models of autism spectrum disorder: a systematic review and meta-analysis
BackgroundAutism spectrum disorder (ASD) is a complicated neurodevelopmental condition that currently lacks a targeted therapy. Although stem cell-derived extracellular vesicles (EVs) represent a potential therapeutic approach for neurological disorders, their efficacy in ASD remains unclear. The objective of this study…
Rethinking childhood-onset schizophrenia: neurodevelopmental comorbidities shape the psychopathological profile
ObjectivesChildhood-onset schizophrenia (COS), defined by the onset of psychotic symptoms before the age of 13 years, is a rare and severe form of schizophrenia. Despite growing interest, little is known about how neurodevelopmental comorbidities shape its clinical presentation. This study…
Repetitive transcranial magnetic stimulation for treatment-resistant depression in Singapore: a retrospective, naturalistic study
IntroductionNaturalistic repetitive transcranial magnetic stimulation (rTMS) outcome data for treatment-resistant depression remain limited in Southeast Asia. This retrospective study describes such outcomes from a general hospital in Singapore.Method28 outpatients received rTMS (10Hz high-frequency or intermittent theta-burst) targeting the left dorsolateral…
Development of a messenger RNA therapy for schizophrenia
Few gene-disease associations identified by human genetic studies lead to new drugs that advance to first-in-human trials. Schizophrenia exemplifies this translational gap: thousands of gene-disease associations have been reported, but antipsychotics act via mechanisms introduced in the 1950s. To close…
Reporter’s Notebook: Cell and Gene Therapy’s Success Lies Beyond the Bespoke (Part 1)
Conversations with the CEOs of Skylark Bio, Prime Medicine, and Celleras and Nanoscope Therapeutics executives highlighted differentiated technologies and scalable platforms serving broader patient populations. The post Reporter’s Notebook: Cell and Gene Therapy’s Success Lies Beyond the Bespoke (Part 1)…
Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty Versus Applied Relaxation
Conditions: Mental Disorders; Mood Disorders; Anxiety Disorders; Generalized Anxiety Disorder Interventions: Behavioral: Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty (CBT-IU); Behavioral: Group Transdiagnostic Applied Relaxation (AR) Sponsors: Medical Research Council Cognition and Brain Sciences Unit; University of Cambridge…
The genetic orchestra of autism and its intersections with epilepsy, intellectual disability, and ADHD
Autism is a complex condition with marked phenotypic variability and a multifactorial etiology orchestrated by diverse genetic and environmental influences. In this review, we dissect what we refer to as autism’s “genetic orchestra”, spanning from the high-impact “soloists”, de novo…
Experts’ Needs Assessment and Evaluation of Mobile Apps for Children of Parents With Mental Illness: Mixed Methods Study
Background: Children of parents with mental health illness (COPMI) have the right to receive preventive interventions to avoid developing their own mental health and socioeconomic problems. However, access to interventions varies widely within health care and social services depending on…
Incorporating Objective Behavioral and Biological Measures in a Large-Scale Decentralized Mobile Health Trial for Depression: Randomized Controlled Trial
Background: Decentralized (ie, fully remote) clinical trials (DCTs) offer a scalable and ecologically valid approach to evaluating digital mental health interventions (DMHIs). Yet, incorporating objective measures of well-being within DCTs poses novel methodological and feasibility challenges that can limit the…
The SNF Global Center Names New Research and Communicator Fellows Ahead of World Mental Health Day 2026
The latest cohort of Fellows will join an international network of experts leading scalable, community-driven innovations in low- and middle-income countries (LMICs). The post The SNF Global Center Names New Research and Communicator Fellows Ahead of World Mental Health Day…
Efficacy of artificial intelligence-driven conversational agents (chatbots) for mental health promotion among university students: a systematic review and meta-analysis
BackgroundUniversity students experience substantial mental-health burdens, while access to timely support remains uneven. AI conversational agents may provide low-threshold support, but the evidence base has expanded rapidly and prior reviews have often combined different age groups, intervention types, outcome domains,…
Exercise for the negative symptoms of schizophrenia: a review
Negative symptoms of schizophrenia, comprising avolition, asociality, anhedonia, blunted affect, and alogia, are a primary driver of functional impairment, tend to persist, and have no treatment approved specifically for them. Exercise has drawn interest as a low-cost, widely available, adjunctive…
Cognitive remediation in schizophrenia: efficacy and role of neuroplasticity in “top-down” and “bottom-up” mechanisms—a randomized, double-blind, treatment-as-usual-controlled study protocol
ObjectivesSchizophrenia is characterized by positive, negative and cognitive symptoms, including different degrees of impairment in several neurocognitive domains, such as executive function, processing speed, learning and memory, which impact a patient´s functioning and quality of life. Cognitive remediation can help…
Feasibility Trial of a Parent Peer-Co-Led Caregiver Group for Pediatric Early Onset Schizophrenia Spectrum Disorders
Conditions: Schizophrenia; Psychosis Interventions: Behavioral: Group Therapy; Other: Treatment as Usual (TAU) Sponsors: Boston Children's Hospital Not yet recruiting
Novel and Conventional Interventions for Cognitive and Emotional Flexibility in Patient Trauma
Conditions: Depression; Anxiety; Trauma Patients Interventions: Drug: D-Cycloserine (DCS); Device: Transcranial Magnetic Stimulation; Behavioral: Unified Protocol; Behavioral: Psychoeducation Sponsors: Mclean Hospital Active, not recruiting
Ensemble of Domain-Specific Natural Language Processing and Large Language Models for Detecting Suicidal Ideation and Mental Health Conditions in Social Media Text: Development and Evaluation Study
Background: Mental illness contributes substantially to global disability, and public adoption of AI for mental health support is accelerating without commensurate safety evaluation. General-purpose large language models can fail to recognize naturalistic text expressing suicidal ideation, with immediate clinical consequences.…
Using App Store Reviews to Explore User Experiences and Perceptions of Mental Health Mobile Apps: Qualitative Study
Background: With the rise of digital health, mental health apps (MHapps) have become an increasingly popular tool in the self-management of depression, anxiety, and stress. Star ratings are often used as indicators of app quality to guide selection. However, ratings…