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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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The association between worry, rumination, and metacognitive beliefs in female adolescents with Anorexia Nervosa
BackgroundA growing body of literature has emphasized the role of worry and rumination in eating disorders (EDs). According to the metacognitive model, worry and rumination are maintained by dysfunctional metacognitive beliefs. Although metacognitive beliefs have been investigated in adults with…
Clinical Study of Non-invasive 40-Hz Audiovisual Stimulation Guided by Gamma EEG Monitoring for Promoting Perioperative Brain Function Recovery in Children
Conditions: ADHD - Attention Deficit Disorder With Hyperactivity Interventions: Device: 40-Hz non-invasive synchronized audiovisual stimulation Sponsors: General Hospital of Ningxia Medical University Not yet recruiting
Group Treatment for Self-harming Adolescents and Their Parents: a Randomized Controlled Trial
Conditions: Self-Harm; Self-Harm, Deliberate; Self-harm Behavior; Non-Suicidal Self Injury; Non-suicidal Self-injury (NSSI) Interventions: Behavioral: Emotion Regulation Group Therapy for Self-harming Adolescents, ERA; Behavioral: Functional habits for mental health, FUNK Sponsors: Karolinska Institutet; Västra Götalandsregionen; Region Stockholm Not yet recruiting
Diagnostic Discrimination of BOKE STARS, a Bimodal Continuous Performance Test, for Attention-Deficit/Hyperactivity Disorder Assessment in Chinese Children: Single-Center Case-Control Study
Background: Attention-deficit/hyperactivity disorder (ADHD) affects 6.3% of Chinese children, but only 10% are diagnosed, as diagnosis is hindered by low awareness and lack of culturally adapted, objective tools. Existing continuous performance tests are unimodal and lack validity. Objective: This study…
Deprexis for Veteran Depression: Open-Label Pilot Trial Examining Feasibility, Acceptability, and Preliminary Efficacy
Background: Depression carries the highest burden of mental health–related disability in the United States. Approximately 13% of military veterans report elevated rates of depression. Despite the availability of evidence-based treatments for depression, nearly 50% of veterans in need of mental…
Developing a Text Messaging Intervention to Increase Uptake of the Screening and Treatment for Anxiety and Depression Program Among Community College Students: Formative Study Using a Human-Centered Design Approach
Background: Community college (CC) students face significant mental health concerns but are unlikely to receive treatment. Barriers to mental health service uptake among CC students have been delineated, but few studies have identified strategies to improve uptake. Text messaging has…
Optimizing Treatment Strategies in the Bipolar Disorder Spectrum With Classical AI Approaches: Systematic Review of Performance, Bias, and Clinical Applicability
Background: Bipolar disorder (BD) is a complex and heterogeneous psychiatric condition, characterized by fluctuating clinical courses that affect approximately 1%‐2% of the global population in their lifetime. Despite pharmacological advances, treatment response varies significantly among patients, making the identification of…
Digital Reassurance Seeking in OCD
– by Jordan Karr, PhD We all need reassurance once in a while. Receiving reassurance from a friend, loved one, or expert can reduce short-term distress, foster a sense of connection,... Read more » The post Digital Reassurance Seeking in OCD…
Curcumin attenuates α-synuclein pathology in Parkinson’s disease model mice through modulation of UBC9-associated SUMOylation signaling
BackgroundPost-translational modifications, particularly SUMOylation, plays a crucial role in α-synuclein (α-syn) aggregation, a key pathological feature of Parkinson’s disease (PD). Curcumin, a natural polyphenol, has shown neuroprotective potential, but its effects on SUMOylation-related signaling in PD remain unclear.ObjectiveThis study aimed…
Subcortical gray matter atrophy and iron deposition in patients with vascular dementia: a multimodal MRI study
PurposeVascular dementia (VAD) is the second most common type of dementia worldwide. Therefore, early detection and diagnosis, along with a clear understanding of its pathogenesis are critical for mitigating disease progression. In the present study, we aimed to elucidate the…
Illness perception, family resilience, and emotional distress among hospitalized older adults with multimorbidity in Xinjiang, China: a latent profile and mediation analysis
BackgroundOlder adults with multimorbidity frequently encounter significant psychological challenges, with negative illness perception being a prevalent issue. Such perceptions can intensify emotional distress. Family resilience—the ability of a family system to adapt positively to adversity—plays a crucial role in alleviating…
Remimazolam versus propofol on seizure adequacy in electroconvulsive therapy: a retrospective cohort study
ObjectiveElectroconvulsive therapy (ECT) is a core treatment modality for severe mental disorders, and the choice of anesthetic induction agent directly impacts seizure quality and therapeutic outcomes. This study aimed to compare the effects of remimazolam versus propofol on seizure adequacy…
Latest developments in the use of e-cigarettes by people with schizophrenia spectrum disorders who smoke: a scoping review
BackgroundTobacco use is significantly more prevalent among individuals with schizophrenia spectrum disorders (SSD) compared to the general population, contributing to elevated rates of premature mortality from smoking-related diseases. Despite a decline in smoking prevalence in the general population, individuals with…
A Study to Assess the Efficacy and Safety of Solriamfetol in Adolescents With ADHD
Conditions: ADHD Interventions: Drug: Solriamfetol Dose A; Drug: Solriamfetol Dose B; Drug: Placebo Sponsors: Axsome Therapeutics, Inc. Recruiting
A Study to Assess the Efficacy and Safety of Solriamfetol in Children With ADHD
Conditions: ADHD Interventions: Drug: Solriamfetol Dose A; Drug: Solriamfetol Dose B; Drug: Placebo Sponsors: Axsome Therapeutics, Inc. Recruiting
Home Play-based Intervention for Parents and Infants
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD); Autism Spectrum Disorder; Premature Birth; Global Developmental Delay Interventions: Behavioral: SPRINT Intervention; Other: Waitlist Protocol Sponsors: Nanyang Technological University; Agency for Science, Technology and Research (A*STAR); KK Women's and Children's Hospital; Institute for Human Development and…
Defining and Assessing Empathic Communication in Patient Portal Secure Messages: Adapted Coding Framework Development Study
Background: Empathic communication in the clinical setting has been associated with improved clinical outcomes, decreased anxiety, and increased patient satisfaction, treatment adherence, and trust. Despite the recent growth in patient portal use, the expression of empathic communication through patient portal…
Protein Protects Against Tau Tangles, Synaptic Loss in Mouse Model of Tauopathy
Scientists found that upregulating a protein known as SORLA offers protection against the effects of tau tangles in a mouse model, pointing to a potential therapeutic strategy for tauopathies including Alzheimer’s disease. The post Protein Protects Against Tau Tangles, Synaptic…
Integrating cognitive-behavioral training with immersive virtual reality intervention in ADHD: a case report
IntroductionAttention-Deficit/Hyperactivity Disorder (ADHD) is a condition characterized by persistent patterns of inattention and/or hyperactivity-impulsivity. This case highlights the potential benefit of integrating Immersive Virtual Reality (IVR) with cognitive-behavioral therapy (CBT) in the rehabilitation of a child with ADHD. It contributes…