Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Thyroid-stimulating hormone, fasting blood glucose and suicidal ideation in Chinese adolescents with major depressive disorder: a cross-sectional study
BackgroundThyroid function and glycolipid metabolic alterations are often associated with major depressive disorder (MDD), yet their roles in suicide risk among adolescents with MDD remain unclear. This study aimed to investigate thyroid-stimulating hormone (TSH) levels, glycolipid metabolism parameters, and their…
Effects of exercise interventions on executive function in autism spectrum disorder: a three-level meta-analytic review
ObjectiveThis study aimed to use a three-level meta-analysis to examine the effects of exercise interventions on executive function (EF) in children and adolescents with autism spectrum disorder (ASD), and to explore the relationship between exercise dose and intervention effects through…
Combining Transcranial Magnetic Stimulation With Emotion Regulation Skills Training in Borderline Personality Disorder
Conditions: Borderline Personality Disorder (BPD) Interventions: Device: Transcranial Magnetic Stimulation (TMS); Behavioral: Emotion Regulation Skills Training Sponsors: Massachusetts General Hospital Not yet recruiting
Transition Care for FEP
Conditions: Schizoaffective Disorders; Bipolar Disorder With Psychotic Features; Schizophrenia Disorders; Major Depressive Disorder With Psychotic Features; Psychosis NOS Interventions: Behavioral: Transition Care Team Sponsors: University of Chicago; Sidney R. Baer, Jr. Foundation Recruiting
StockWatch: Lilly’s Up-to-$3.8B Deal for AtaiBeckley a Good Trip for Psychedelic Drugs, Analysts and Investors Agree
Eli Lilly agreed to acquire AtaiBeckley for up to $3.8 billion—of which Lilly will pay $2.8 billion upfront. The deal, set to close in the third quarter, expands Lilly’s neuroscience portfolio by adding AtaiBeckley's pipeline led by BPL-003 (mebufotenin benzoate).…
Development and validation of the digital well-being scale using university students
IntroductionDigital technologies are central to university students' academic, social, and personal lives, offering opportunities for learning and connection while also introducing challenges such as distraction, emotional strain, and difficulties with self-regulation. Despite increasing interest in digital well-being, there is a…
Immersive Technologies in Forensic Mental Health and Prison Settings: Scoping Review
Background: The application of immersive technologies, particularly virtual reality, has expanded rapidly across health care domains, including mental health, rehabilitation, and education. These technologies enable the creation of controlled, interactive, and ecologically valid environments that can support therapeutic interventions, skill…
Effects of Social Media Narratives on Affective and Behavioral Responses to Menopause Content: Randomized Online Experimental Study
Background: Social media is an increasingly prominent channel for communicating menopause information and experiences, yet the affective and behavioral consequences of different narrative framings remain unclear. Objective: We examined how distress, normalizing, and transformative narratives influenced women’s immediate responses to…
Playing the Long Game for Youth Mental Health: A conversation with Grassroot Soccer on the power of sport and partnership
We spoke with Grassroot Soccer’s Mental Health Specialist Charmaine Nyakonda about the organization’s approach, the impact of their collaboration with SNF, and the growing role of sports in improving the mental health of young people and communities globally. The post…
Altered tryptophan metabolism as a contributor to cognitive impairment in chronic kidney disease: a narrative review
Approximately 40% of patients with chronic kidney disease (CKD) experience cognitive impairment (CI), which is strongly associated with increased mortality. CI is driven by multiple factors, including vascular injury, accumulation of uremic toxins, disruption of the blood–brain barrier, and chronic…
Physical education performance as a protective pathway: breaking the cycle between learning burnout and gaming disorder in Chinese adolescents
Background and AimsGaming disorder (GD) and learning burnout (LB) are critical issues impacting adolescents, with GD recognized by the World Health Organization as a behavioral addiction and LB contributing to academic disengagement. While prior research has examined bivariate relationships, such…
Pharmacotherapy, acupoint stimulation, and psychotherapy for perimenopausal women with anxiety, depression, and panic disorder: a systematic review and network meta-analysis of randomized controlled trials
BackgroundPerimenopausal women frequently experience physiological and psychological symptoms, including anxiety, depression, and panic disorders, mainly due to declining ovarian function and hormonal changes. Current options include pharmacotherapy, acupoint stimulation (AcuStim), and psychotherapy (psych), but their comparative efficacy and safety remain…
CD163+ perivascular macrophages in schizophrenia: a research framework for testing macrophage-related mechanisms
Elevated densities of CD163+ perivascular macrophages have been reported in schizophrenia post-mortem brain tissue, particularly in regions involved in neurodevelopment, dopaminergic signaling, and blood–brain barrier (BBB) regulation. However, the biological significance and developmental lineage of these findings remain unclear. While…
Opinion: MAHA is rewriting the vocabulary of American mental health care
“‘Deprescribing’ elevated into a movement, and a cultural default, is a clinical hazard,” writes Sunny Patel.
Evaluation of Foquest in Adults 65 Years and Older With ADHD
Conditions: Attention Deficit Hyperactivity Disorder Interventions: Drug: Methylphenidate hydrochloride extended-release capsules Sponsors: Dar Clinical Research Inc. Not yet recruiting
See, Blind Mice: Consortium’s Drugs Restore Sight
Researchers developed a series of light-activated small molecule drugs that mimic the function of the light-sensing photoreceptor cells that degenerate in diseases such as age-related macular degeneration and retinitis pigmentosa, and which in tests restored sight in blind mice. The…
A study on the relationship between research stress, research anxiety, research performance, and job satisfaction among Chinese healthcare professionals and its influencing mechanisms: a national multi-center survey
BackgroundChinese healthcare professionals face dual pressures from clinical duties and research activities, which may increase research-related anxiety and reduce job satisfaction. While occupational stress has been well studied, the mechanisms linking research stress to job satisfaction are unclear. Research performance…
ADHD as a disorder of operational capacity: a buffered-state framework for sustained engagement instability
Attention-deficit/hyperactivity disorder (ADHD) is commonly conceptualized as a disorder of executive dysfunction or impaired motivation. In clinical practice, however, many individuals with ADHD describe a different core difficulty: they can initiate tasks appropriately, understand goals, and exert effort, yet struggle…
Altered EEG microstate dynamics in adolescents with non-suicidal self-injury at rest and following acute social exclusion
BackgroundNon-suicidal self-injury (NSSI) is highly prevalent in adolescence, yet the fast dynamics of large-scale brain networks remain poorly understood. We aimed to characterize resting-state EEG microstate dynamics in a clinically recruited adolescent NSSI sample and to examine state-dependent changes following…
Fragile self, mechanical world: mechanistic delusions and ego fragility in schizotypal–affective spectrum disorder—a CARE case report
Categorical nosological systems frequently fall short when confronted with patients whose presentations cross established diagnostic boundaries. We report M.S., a 44-year-old Brazilian man involuntarily admitted to a psychiatric inpatient unit who presented with systematized persecutory ideation of mechanistic–technological content (chip…