Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Occupational burnout and risk of suicidality in healthcare professionals: a PRISMA-guided systematic review
BackgroundBurnout, an occupational phenomenon resulting from chronic workplace stress that has not been successfully managed, is increasingly recognized as a critical threat to the mental health of healthcare professionals. Prolonged exposure to work-related stressors may increase the risk of suicidality,…
TeleABA for Hospitalized Adolescents and Young Adults With Autism Spectrum Disorder
Conditions: Autism Spectrum Disorder (ASD) Interventions: Behavioral: Standard Hospital Care; Behavioral: Telehealth Applied Behavior Analysis (TeleABA) Sponsors: Caring Technologies, Inc.; National Institute of Mental Health (NIMH); Hackensack Meridian Health; Center for Social Dynamics; Rutgers University Not yet recruiting
Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder
Conditions: Major Depressive Disorder; Post-Traumatic Stress Disorder (PTSD) Interventions: Drug: Psilocybin; Behavioral: Structured Integrated Reframing Therapy (SIRT); Drug: Selective Serotonin Reuptake Inhibitor (SSRI) Sponsors: Khyber Medical University Peshawar; Hayatabad Medical Complex; KMU Institute of Health Science, Islamabad Recruiting
VR-Based Behavioral Activation in Adults
Conditions: Depression - Major Depressive Disorder; Behavioral Activation; Virtual Reality Therapy; Behavioral Inhibition Interventions: Device: Virtual Reality Behavioral Activation Software; Behavioral: Waitlist Control and Psychoeducation Sponsors: KTO Karatay University Completed
Digital Mindfulness-Based Therapy for Obsessive-Compulsive Disorder
Conditions: Obsessive-Compulsive Disorder Interventions: Behavioral: Digital Mindfulness-Based Therapy; Drug: Routine Pharmacological Treatment Sponsors: Central South University; Second Xiangya Hospital of Central South University Not yet recruiting
A Web-Based Self-Management Intervention for Return-to-Work Among Persons With Common Mental Disorders on Sick Leave: Case Study of mWorks
Background: mWorks is a co-designed, web-based self-management intervention developed to empower persons with common mental disorders who are on sick leave during the return-to-work process. However, limited knowledge of how mWorks is delivered and engaged with in real-world settings constrains…
Development and Formative Evaluation of a Narrative-Based Serious Game for Pregnancy Education: Mixed Methods Study
Background: Serious games are increasingly used in professional health education and maternal health promotion. However, most pregnancy-related digital interventions target specific behaviors and do not provide a comprehensive, longitudinal simulation of the pregnancy journey that incorporates psychosocial and administrative aspects.…
Perspectives on Remote Monitoring via Smartphones and Wearables Among Individuals With Lived Experience or at Risk of Eating Disorders (“This Could Go Very, Very Wrong”): Qualitative Interview Study
Background: Remote measurement technology (RMT) is increasingly used in health research to collect real-world data relevant to clinical states (eg, sleep, activity, and stress). Concerns exist about the impact of remote tracking via personal devices and wearables on individuals with…
Very Low Uptake in Workplace Semen Analysis Research: Formative Web-Based Cross-Sectional Follow-Up Survey Distinguishing Employees With Self-Reported Unawareness From Aware Nonparticipants
Background: Very low uptake in workplace semen analysis research is difficult to interpret, particularly in employer-adjacent settings, where nonparticipation may reflect limited recruitment reach, limited understanding of the occupational rationale, low perceived relevance, or procedure-related concerns. Objective: This post hoc…
Autism-Related Information on Websites and General-Purpose Artificial Intelligence Chatbots: Comparative, Bilingual Study
Background: Parents increasingly consult the internet, both websites and, more recently, artificial intelligence chatbots, for information on autism spectrum disorder (ASD). However, the comparative quality of these two source types, especially across languages, remains underexplored. Objective: This study aimed to…
AI Agents Are Coming: 5-Stage Taxonomy of Language-Based AI Systems for Psychiatry, Psychotherapy, and Counseling
The rapid evolution of large language models has accelerated the development of agentic artificial intelligence (AI) systems capable of pursuing autonomous goals, creating an urgent need for structural frameworks in psychiatry and psychotherapy. While existing classifications often draw parallels to…
Attention-deficit/hyperactivity disorder and chronic pain: a scoping review of epidemiology, clinical phenotypes, mechanisms, and treatment
IntroductionEmerging evidence suggests a potential association between attention-deficit/hyperactivity disorder (ADHD) and chronic pain; however, extant findings are dispersed across disciplines and have not yet been comprehensively synthesized. This scoping review aimed to systematically map the epidemiological evidence, clinical phenotypes, proposed…
Family caregivers’ involvement in home-based recovery for patients with schizophrenia: a qualitative study in Beijing, China
BackgroundFamily caregivers play critical roles in supporting the home-based recovery of patients with schizophrenia, but they often encounter substantial challenges and receive insufficient systemic support. Understanding caregivers’ involvement in home-based recovery is essential for aligning community mental health services with…
Case Report: A novel de novo heterozygous truncating mutation in MED12L identified in a Chinese autistic boy
BackgroundAutism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder. A previous study by Nizon et al. indicated that some children with intellectual disability (ID) carrying de novo MED12L mutations exhibited mild to moderate autistic features. However, the relationship between MED12L…
STAT+: HHS presses ahead with effort to curb antidepressant use
In a private meeting, HHS officials met with mental health professionals to work on guidance for stopping SSRIs.
A Sensory-Profile Framework for Differentiated Swim Instruction in Autistic Children
Conditions: ASD Interventions: Behavioral: sensory-based instruction; Behavioral: standard instruction Sponsors: Genesis Indep Research Completed
HALO-TRIAL: High, Medium And LOw Intensity Psychotherapy for Binge Eating Disorder
Conditions: Binge Eating Disorder; Binge Eating Episodes; Binge Eating/Loss of Control Eating; Binge Eating Disorders; Binge Eating; Binge Eating Behaviour; Binge Eating Disorder Associated With Obesity; Eating Disorder Binge; Eating Disorders Interventions: Behavioral: Cognitive Behavioral Therapy Enhanced - Individual; Behavioral:…
Efficacy of a Gamified Blended Mindfulness Program to Reduce Burnout, Stress, and Anxiety in Nursing Students: A Randomized Controlled Trial
Conditions: Burnout Syndrome; Psychological Stress, Anxiety, and Depression Associated With Academic Pressure; Anxiety Interventions: Behavioral: Psychoeducation and Free App Recommendation; Behavioral: Standard Blended Mindfulness Program; Behavioral: Gamified Blended Mindfulness Program Sponsors: Universidad de Granada Completed
Digital Mental Health Research Priorities, Revisited for the AI and Large Language Model Era
Digital mental health has become an established part of mental health care, but the rapid arrival of large language models and other artificial intelligence tools has refocused attention on the evidence needed to guide the field. This editorial updates the…
Maintaining Emotional Boundaries as a Parent
Parents often emphasize to children the importance of respecting others’ boundaries — don’t tickle another kid if they say they don’t like it, for example. Don’t kiss someone unless they welcome it. But within the family, we can fail to…