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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Routine Online Psychological Therapy in an Insurance-Based Care Setting: Retrospective Service Evaluation of Real-World Outcomes
Background: Depression, anxiety, and stress-related difficulties represent a major global health burden. Online psychological therapy has emerged as a promising approach to increasing access to care, yet evidence from routine, real-world clinical settings, particularly for services delivered without standardized treatment…
Perinatal Mental Health Detection and Prediction Using Mobile Sensing Data: Systematic Review
Background: Perinatal mental health disorders affect approximately 20% of pregnant and postpartum individuals, and are associated with substantial maternal and infant morbidity. Traditional assessment relies on infrequent, subjective self-reports. Mobile devices, including smartphones and wearables, offer opportunities for continuous and…
Possible Role and Function of AI Conversational Agents in Dialectical Behavior Therapy for Borderline Personality Disorder: Qualitative Interview Study
Background: Borderline personality disorder (BPD) is associated with substantial distress and a high risk for suicide. Individuals with BPD may be unable to access evidence-based treatments like dialectical behavior therapy (DBT). Artificial intelligence conversational agents (AI-CA) are increasingly discussed as…
Assessing the Need for Mental Health Support From Free-Text Responses: Development and Validation of Language-Based Assessments in Adults With Internalizing Symptoms
Background: Machine learning and natural language processing have demonstrated significant potential for mental health assessment: describing your mental health in your own words can offer a more ecologically valid approach than traditional rating scales. However, most models focus on specific…
Biological hierarchy from genotype to phenotype in syndromic and non-syndromic autism spectrum disorder
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition whose pathophysiology is thought to arise from complex interactions among genetic variation, molecular and cellular perturbations, and neural circuit dysfunction. Although the distinction between syndromic and non-syndromic ASD was introduced as…
Non-motor correlates of anxiety in de novo Parkinson’s disease: a cross-sectional study with exploratory subgroup analyses
ObjectiveAnxiety is a prevalent early non-motor symptom of Parkinson’s disease (PD), but its clinical correlates remain poorly defined in de novo, drug-naïve patients. This retrospective cross-sectional study enrolled 284 medication-naïve de novo PD patients and 147 age- and sex-matched healthy…
Metabolic dysfunction associates with neuroimaging measures of brain structure and connectivity
IntroductionMetabolic syndrome (MetS) and insulin resistance are established risk factors for Alzheimer’s disease (AD) and have been linked to alterations in brain structure and function, including within the Default Mode Network (DMN).MethodsHere, we examined associations between metabolic dysfunction, brain structure,…
Trauma-informed psychological support alongside long-acting injectable buprenorphine: clients’ perspectives on the Buvidal psychological support service (BPSS) pilot in Wales
BackgroundOpioid use disorder (OUD) is associated with persistent drug use, high relapse rates, and significant morbidity, mortality, and psychosocial harm. While Long-Acting Injectable Buprenorphine (LAIB), marketed as Buvidal, offers improved pharmacological management over traditional opioid substitution therapy (OST), the mental…
Factors associated with school absenteeism in adolescents with mental illness: a multivariate analysis
Backgroundschool absenteeism is a common functional impairment among adolescents with mental disorders, yet its associated factors remain limited. This study aimed to identify key demographic, clinical, and social factors associated with school absenteeism in this population.MethodsA retrospective cohort study was…
Maternal emotional distress, caregiving burden, and service access among mothers of children with autism spectrum disorder: a qualitative study
IntroductionMothers raising children with autism spectrum disorder (ASD) may experience substantial emotional distress and caregiving burden, whilst family support andaccess to services can shape how these demands are managed. Yet in-depthqualitative evidence on these public mental health dimensions remains limited…
Emotional maltreatment and problematic short-video use among adolescents: an indirect association through narcissism and moderation of the direct association by physical activity
IntroductionEmotional maltreatment has been associated with problematic short-video use during adolescence, but the nature of this association remains unclear. This cross-sectional study examined the association between emotional maltreatment and problematic short-video use, estimated the indirect statistical association through narcissism, and…
STAT+: The head of Kennedy’s new autism project served in Iraq War, worked with Sesame Street
Advanced Research Projects Agency for Health is planning a total-lifespan research project on autism: A Q&A with its leader, Russell Shilling.
Acceptability and Efficacy of a Culturally Adapted, Low-Frequency Parent-Mediated Early Start Denver Model (ESDM) Versus Standard Care in Young Children With Autism
Conditions: Autism Spectrum Disorder Interventions: Behavioral: Early Start Denver Model Sponsors: National University Hospital, Singapore Completed
AI Mental Health Tool vs. Psychoeducation Control
Conditions: Depressive Disorder; Depressive Symptoms Interventions: Behavioral: Ash; Behavioral: Brief Therapist-Delivered Telehealth Sponsors: Slingshot AI Active, not recruiting
A Persian AI-Based CBT Chatbot and Voice Analysis System for Managing Perceived Stress
Conditions: Psychological Stress; Perceived Stress Interventions: Behavioral: Persian AI-Based CBT Chatbot; Behavioral: Active Mental Health Content Sponsors: Hamid Reza Marateb; Isfahan University of Medical Sciences; University of Isfahan Not yet recruiting
Identifying Suicide Risk Based on the Words People Use
Researchers from the Child Mind Institute and MIT have developed a tool that can identify warning signs in text conversations, helping experts better understand who may need urgent support. The post Identifying Suicide Risk Based on the Words People Use…
Practical Guide to Large Language Models for Information Extraction in Behavioral Health Notes: Tutorial
Background: Mental health clinical notes contain decision-critical information often absent from structured electronic health record fields. Large language models (LLMs) can extract clinically relevant signals from narrative text; however, variability in output format, limited reproducibility, and inconsistent evaluation remain barriers…
Prevalence of positive screens for depression, anxiety, and PTSD symptoms among parents of infants admitted to a NICU: a pilot study
IntroductionParents of infants admitted to the Neonatal Intensive Care Unit (NICU) may experience substantial psychological distress. This study aimed to assess the prevalence of positive screens for depressive, anxiety, and post-traumatic stress disorder (PTSD) symptoms and to explore their associations…