Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Effects of psychedelic drug use on neurocognitive function and the psychological and social domains of quality of life: an international online study
BackgroundThe past few decades have seen a revived interest in psychedelic-assisted and ketamine-assisted therapy for mental health disorders, but data concerning the acute, subacute, and long-term effects of serotonergic psychedelics on cognitive functioning are scarce. This international, online study (N = 759)…
Effect of transcranial alternating current stimulation (NET Device™) on psychostimulant withdrawal severity and time course: a real-world data analysis
BackgroundPsychostimulant use disorder is a life-threatening condition with no FDA-approved treatment. Stimulant withdrawal symptoms impede treatment engagement and are unaddressed by standard of care. The NET Device, a non-invasive transcranial alternating current stimulator, is FDA-cleared for opioid withdrawal suppression. No…
Exploring the interplay of discrimination perception, alexithymia, and shyness among hearing-impaired college students: a network approach
BackgroundHearing-impaired college students face limitations in auditory and verbal communication, placing them at higher risk for mental health problems. While previous studies have mostly used traditional structural equation models to examine the relationship between discrimination perception and psychological adaptation issues,…
Case Report: Rapid resolution of psychogenic cough in an adolescent following bromazepam treatment
BackgroundSomatic cough syndrome, formerly termed psychogenic cough or habit cough, is an under-recognized cause of chronic cough in pediatric populations, characterized by repetitive, dry, and honking cough that is absent during sleep. Behavioral interventions are first-line treatment with high success…
Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With ADHD and Cannabis Use Disorder
Conditions: ADHD; Cannabis Use Disorder Interventions: Drug: Delayed-release, extended-release methylphenidate; Drug: Placebo Sponsors: Massachusetts General Hospital; National Institute on Drug Abuse (NIDA); Collegium Pharmaceutical, Inc. Not yet recruiting
Enhancing Emotion Regulation in Children With Autism Through Extended Reality
Conditions: Autism; Emotion Regulation Difficulties Interventions: Behavioral: Extended Reality; Behavioral: Emotion regulation coaching Sponsors: Johannes Kepler University of Linz; Interdisciplinary Transformation University Austria; Hospital of St.John of God, Linz Completed
Implementing BEAM: A Scalable Digital Mental Health Program, for Families of Children Referred to Neurodevelopmental Services
Conditions: Depression and Anxiety Symptom; Anger; Parenting; Stress (Psychology); Parent Child Relationship; Child Development; Neurodevelopmental Conditions Interventions: Behavioral: The Building Emotional Awareness and Mental Health (BEAM) Program Sponsors: University of Manitoba; Children's Hospital Research Institute of Manitoba; Kids Brain Health…
Creative Art Teletherapy for Veterans With PTSD
Conditions: Post-Traumatic Stress Disorder F03.950.750.500 D013313 Interventions: Behavioral: Art-therapy Remote Treatment for Veterans Experiencing Trauma Sponsors: VA Office of Research and Development; Henry M. Jackson Foundation for the Advancement of Military Medicine; Drexel University Not yet recruiting
Standardized Manual-Based Smoking Cessation Treatment in Patients With Comorbid Mental Disorders: Qualitative Interview Study
Background: Smoking prevalence is disproportionately high among individuals with mental disorders, who also show reduced cessation success, suggesting that current cessation interventions may not fully address their specific needs. A barrier to smoking cessation is the fear that quitting may…
Trajectories of Persistent Exposure to Self-Harm–Encouraging Websites and Subsequent Mental Health Outcomes in US Youth: Longitudinal Cohort Study
Background: Self-harm, including suicidal thoughts, self-injurious behavior, and disordered eating, is a major public health concern among adolescents and young adults. Youth increasingly encounter self-harm–related content online, including websites that explicitly encourage harmful behaviors. Although exposure to such content has…
Relationship between loneliness and self-efficacy: the mediating role of internet addiction and the moderating role of sleep quality
IntroductionThis study aimed to examine the association between loneliness and self-efficacy among adolescents and to investigate whether internet addiction mediated this association and whether sleep quality moderated the direct and indirect pathways. Although previous research has demonstrated significant associations between…
Beyond dopamine: KarXT and emerging mechanism-based therapies in schizophrenia
KarXT (marketed as Cobenfy™), a fixed-dose combination of xanomeline and trospium chloride, represents the first new mechanism of action of an antipsychotic used for adult schizophrenia approved by the US Food and Drug Administration (FDA) in over 30 years. While…
Maternal folate receptor alpha autoantibodies and folate levels during pregnancy in relation to autism spectrum disorder: a pilot case-control study
BackgroundFolate receptor alpha autoantibodies (FRAA) are reported to be associated with autism spectrum disorder (ASD) and are found more frequently in mothers of children with ASD. However, the relationship between maternal FRAA during pregnancy, folate status, and ASD risk in…
Low-burden speech-based screening of depressive symptoms using ultra-short speech samples
BackgroundSpeech holds promise for depressive symptom screening, but practical applications require clearer guidance on effective segmentation, optimal speech tasks, minimum duration, and feature-model matching.ObjectiveTo enable low-burden screening for depressive symptoms, this study aims to evaluate the effectiveness of short speech…
Opinion: Mentally ill women deserve more support to have children
“The maternal mental health needs of women like me have been badly underprioritized in American society,” writes Meg LeDuc.
Novel Approaches to Supporting Students With ADHD in Multi-Tiered Systems of Support
Conditions: Attention Deficit Hyerpactivity Disorder Interventions: Behavioral: Academic Competency Enhancement (ACE) classroom; Behavioral: School as Usual Classroom Supports Sponsors: Florida International University Not yet recruiting
Predicting the Outcome of ADHD in White Matter Injure Neonates With Multi-modality MRI
Conditions: White Matter Abnormalities, Nonspecific; ADHD; Neurodevelopment Outcome Sponsors: First Affiliated Hospital Xi'an Jiaotong University Completed
Irreconcilable differences?: epistemic injustice and the integration of mental healthcare for LGBTQ+ young people
BackgroundIntegrated youth mental healthcare is an approach that has evolved in response to the global escalation of young people’s poor mental health, and the failure of current mental health systems and models to improve this situation. Lesbian, gay, bisexual, transgender,…
In Vivo Characterization of Fatty Acid Amide Hydrolase in Posttraumatic Stress Disorder: A [11C]CURB Positron Emission Tomography Study
Posttraumatic stress disorder (PTSD) is associated with impaired fear extinction and dysfunction in amygdala-centered circuits, for which treatments remain insufficient. The endocannabinoid system, particularly anandamide signaling regulated by fatty acid amide hydrolase (FAAH), has been implicated in stress and fear…
Effectiveness and Usability of Digital Slow Breathing and Detached Mindfulness Interventions in Late Adolescents: Mixed Methods Study
Background: Many adolescents experience elevated stress and anxiety; yet, access to effective psychological support is limited. Brief digital mental health interventions, such as slow breathing (SB) and detached mindfulness (DM), offer a potentially scalable approach to promoting emotion regulation in…