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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Beyond dopamine blockade: mechanistic humility and the rise of muscarinic, TAAR1, and glutamatergic pathways in schizophrenia
The approval of the first non–dopamine-blocking therapy for schizophrenia marks a defining moment in psychiatry. Muscarinic M1/M4 modulation, alongside emerging TAAR1 and glutamatergic pathways, signals a shift beyond dopamine dominance toward circuit-level integration. These advances embody mechanistic humility: the scientific…
Digital Health Coffee Time Briefing ☕
Today's briefing features a free digital platform built for unpaid carers in the UK and an AI-enabled platform for eating disorder services.
What The Atlantic Missed About OCD: There Is Hope
Dear Editor, The Atlantic’s recent article, “When Mentally Ill Teenagers Ask to Be Put to Death,” brings needed attention to the profound and often misunderstood suffering caused by obsessive compulsive... Read more » The post What The Atlantic Missed About…
IOCDF Calls for Reinstatement of SAMHSA Grants, Renewed Commitment to Mental Health Support
The International OCD Foundation is alarmed by the apparent sudden and widespread termination of grants supporting vital mental health and addiction services previously funded through the U.S. Substance Abuse and... Read more » The post IOCDF Calls for Reinstatement of…
Facing the Monster: My Journey Living with OCD and Finding Hope
by David Kedeme I remember the day my white high top Puma sneakers my parents gifted me for Christmas became the exact opposite of the color they came boxed in.... Read more » The post Facing the Monster: My Journey…
Attenuation of mGluR1/5-dependent synaptic plasticity and ERK pathway dysfunction in the hippocampus of diabetic rats
Streptozotocin-induced diabetic rats (STZ rats), an established animal model of type 1 diabetes mellitus, develop cognitive decline, which has been linked to impairments in hippocampal synaptic plasticity. Long-term depression (LTD) in the hippocampus may be induced by the activation of…
Commercial or industrial use of mental health data for research: primer and best-practice guidelines from the DATAMIND patient/public Lived Experience Advisory Group
BackgroundRoutinely collected health data, such as that held by United Kingdom (UK) national health services (NHS), has important research uses. However, its use requires public trust and transparency. Access by commercial/industrial organisations is especially sensitive for the public, as is…
Synergies in psychedelic-assisted therapy: a qualitative interview study of psychotherapeutic processes
Research on the therapeutic effects of psychedelics in psychiatry, commonly referred to as Psychedelic-Assisted Therapy (PAT), has expanded substantially in recent years. The context-dependent nature of psychedelics has sparked discussion about the importance of the psychotherapeutic environment in achieving beneficial…
Asking for help: the development of a simulation-based mental health application to enhance depression literacy, mental health communication, and help-seeking among Black autistic youth
Black autistic youth experience disproportionately high rates of depression and face intersecting barriers such as racial discrimination, stigma, and limited access to care, yet few interventions address their needs. This study introduces Asking for Help (A4H), a culturally responsive, simulation-based…
Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics
Trauma can contribute to lasting psychological, behavioral, and physiological effects that extend across generations. Intergenerational trauma refers to trauma-related effects observed in children of exposed parents, while transgenerational trauma describes effects observed in later generations without direct exposure. Proposed mechanisms…
Internet addiction in adolescents with suicidal ideation: the role of self-esteem and school connectedness
BackgroundInternet addiction (IA) has become a growing concern, particularly among adolescents, due to its adverse effects on mental health, physical well-being, and future development. Adolescents with suicidal ideation (SI) are particularly vulnerable to IA, which may be associated with a…
The Role of Disulfide Bonds in the GluN1 Subunit in the Early Trafficking and Functional Properties of GluN1/GluN2 and GluN1/GluN3 NMDA Receptors
N-Methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors essential for excitatory neurotransmission. Previous studies proposed the existence of four disulfide bonds in the GluN1 subunit; however, their role in NMDAR trafficking remains unclear. Our study first confirmed the existence of four…
Closing the Gap in Autism Genetics: Population-Specific Variants and the Imperative for Global Inclusion
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental condition with an exceptionally complex and heterogeneous genetic architecture, encompassing both polygenic common variants and rare, high-impact variants. Over the past decade, large-scale sequencing studies in Europe and North America have…
World Mental Health Day Statement
Ottawa – October 10, 2025 As someone who has worked in countries affected by conflict and humanitarian crises, I’ve learned that physical displacement is only part of the story. The mental and emotional toll defines the other half of that…
Canada Gets its First National Guidance on AI for Mental and Substance Use Health
Ottawa (ONTARIO) – In a first-of-its-kind initiative, national guidance for using artificial intelligence (AI) in the mental and substance use health field is being developed through a partnership between the Canadian Centre on Substance Use and Addiction (CCSA) and the…
Beyond Survival: Addressing the Mental Health Crisis Among the World’s Displaced
By Karla Thorpe, Vice President, Programs and Priorities, Mental Health Commission of Canada. The statistics are staggering, but they represent real human lives: 117 million people worldwide have been forcibly displaced from their homes due to war, famine, and other…
Hertfordshire Community NHS Trust to roll out AI-scribing
Hertfordshire Community NHS Trust is rolling out ambient voice technology following a pilot in community and mental health services.
Development of the Healthy Women Intervention to Increase Women’s Engagement in Medication Treatment for Opioid Use Disorder: Mixed Methods, User-Centered Design Approach
Background: Rates of opioid use disorder (OUD) have increased among women over the past 2 decades. Medication treatment for opioid use disorder (MOUD) is effective but underused. Gender-specific treatments for women have been associated with improved substance use outcomes. However,…
Help-Seeking in the Age of AI: Cross-Sectional Survey of the Use and Perceptions of AI-Based Mental Health Support Among US Adults
Background: Anecdotal evidence suggests that an increasing number of people are turning to generative artificial intelligence (GenAI) tools or artificial intelligence (AI)-assisted chatbots to discuss and manage mental health concerns. However, systematic data on the use and perception of such…
Mass Media Narratives of Psychiatric Adverse Events Associated With Generative AI Chatbots: Rapid Scoping Review
Background: Generative artificial intelligence (AI) chatbots have rapidly entered public use, including in contexts involving emotional support and mental health–related interactions. Although these systems are increasingly accessible, concerns have emerged regarding potential adverse psychiatric outcomes reported in public discourse, including…