Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Emotion regulation difficulties and experiential avoidance in adolescents with non-suicidal self-injury: a latent profile and moderation analysis
BackgroundNon-suicidal self-injury (NSSI) represents a significant clinical concern among adolescents. Although emotion regulation difficulties (ERD) and experiential avoidance are associated with NSSI, how these regulatory vulnerabilities co-occur within individuals and whether experiential avoidance influences the ERD–NSSI association remain unclear. This…
STAT+: Definium’s LSD therapy eased anxiety in second large trial
The first wave of biotechs is nearing regulatory approval for psychedelic therapies, a class of treatments that appear to exert rapid benefits.
Screening and Monitoring of Mental Health in Educational Settings: Programme for Detection, Psychoeducation and Self-help
Conditions: Anxiety; Depression Disorder; Bullying; Addiction; Suicide; Self Harm; Psychosis; Eating Disorders Interventions: Other: program for the detection, referral, and psychoeducation in adolescents Sponsors: Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; Hospital Universitario Rey Juan Carlos; Hospital Universitario…
Comparisons of the structure and function of higher cortical circuits in marmosets and macaques: Models for mental health disorders
Non-human primates are extremely valuable for neuroscience research due to their strong homology to humans. Marmosets are small, highly social primates, amenable to genetic and circuit manipulations. Macaques, a larger and more aggressive primate, have been the non-human primate model…
Neurophysiological Signatures of Negative Symptom Improvement After High-Definition Transcranial Direct Current Stimulation: A Transcranial Magnetic Stimulation-Electroencephalography Study
Schizophrenia remains a major health challenge, partly because conventional antipsychotics show limited efficacy for negative symptoms. High-definition transcranial direct current stimulation (HD-tDCS) may improve these symptoms, but its neurophysiological mechanisms remain unclear.
Dexamphetamine-induced striatal hyperdopaminergia attenuates reward-related neural activation: A11C-PHNO PET-fMRI study
Ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC) encode the value of stimulus and outcome phases in a context-dependent manner to support motivated behaviour. In psychosis, disrupted motivational coding has been hypothesised to contribute to negative symptoms via reduced sensitivity…
[Corrections] Correction to Lancet Public Health 2026; 11: e506–17
Gustafsson T T, Pauly V, Hamina A, et al. Cause-specific mortality due to physical illness in severe mental disorders in Europe: a population-based multi-country cohort study. Lancet Public Health 2026; 11: e506–17—In this Article, the spelling of Coralie Gandré's name…
[Comment] Relapse or rebound: the case for personalisation in antipsychotic discontinuation
For people with schizophrenia and their psychiatrists, deciding whether to discontinue antipsychotic treatment is a crucial decision. On average, stopping medication roughly doubles relapse risk and increases rates of rehospitalisation and mortality.1,2 However, continued treatment carries its own burden of…
[Editorial] The long walk to antipsychotic availability
The provision of medicines to all patients in need is a worthy goal but one that is rarely met in mental health. A new initiative from MedAccess and the Clinton Health Access Initiative plans to build on successes in disease…
[Comment] Psychodynamic psychotherapy in schizophrenia: where do we stand?
The role of psychodynamic psychotherapy for schizophrenia spectrum disorders has been debated for decades. During the 1960s and 1970s, psychodynamic and psychoanalytical therapies were widely used and were often the main treatment for individuals with schizophrenia-spectrum disorders.1 However, as more…
Altered long-range visual hierarchical connectivity in internet gaming disorder: reduced V1–LOC connectivity and its association with addiction severity
BackgroundNeuroimaging studies of internet gaming disorder (IGD) have primarily focused on reward-related and executive-control networks. However, sensory processing of addiction-related cues, particularly visual processing, may also contribute to IGD. Whether the intrinsic hierarchical organization of the visual system is altered…
Association of Herpes Simplex Virus Type-1 With Dementia Outcomes: Longitudinal Retrospective Cohort Study Using Real-World Electronic Health Record Data
Background: Global dementia cases, currently exceeding 55 million, are projected to triple by 2050. In the absence of disease-modifying therapies, identifying modifiable risk factors is critical. Preclinical studies show that herpes simplex virus type-1 (HSV-1) is neurotropic and can drive…
Emerging Adults’ Experiences of Digital Measurement-Based Care in Routine Mental Health Care: Qualitative Study and Conceptual Synthesis
Background: Emerging adults (aged 18‐29 years) experience a high burden of mental health (MH) concerns during a developmental period marked by increasing autonomy and vulnerability to symptom onset. Many emerging adults face challenges in accessing and sustaining engagement with developmentally…
A Mobile App for Student Veterans With Co-Occurring Academic and Psychiatric Concerns: Pilot Usability and Feasibility Study
Background: Over 600,000 student veterans use military benefits to pursue higher education annually, with 75% enrolled as full-time students. Advancing their education is an important step toward improving their employment, financial, and social opportunities. However, student veterans also experience high…
Therapist Skepticism and Adaptation to Teletherapy Under Enforced Uptake, With Theoretical Considerations for AI-Mediated Care: Qualitative Study
Background: Mental health care is undergoing rapid digital transformation, with continued development and implementation of digitally delivered interventions. Despite growing evidence for digital mental health interventions, implementation in routine practice has often lagged technological advances. Although teletherapy became more widely…
Comparative efficacy of neuromodulation techniques for Alzheimer’s disease: a systematic review and network meta-analysis of randomized controlled trials
BackgroundNeuromodulation techniques (NMTs) have shown potential therapeutic value in Alzheimer’s disease (AD), but the comparative efficacy of different modalities remains unclear. This study aimed to systematically compare and rank available NMTs to identify their relative benefits across cognitive, functional, and…
Large language models for late-life depression: a blinded benchmark of clinical safety, geriatric appropriateness, and triage
BackgroundGeneral-purpose large language models are increasingly used by patients and caregivers to obtain mental health information and guidance about when professional care is required. In late-life depression, broadly accurate information may nevertheless be unsafe when cognitive change, multimorbidity, frailty, polypharmacy,…
Recovery-phase symptoms after COVID-19 infection and anxiety levels among college students
ObjectiveThis study examines the relationship between physical symptoms during the recovery phase after COVID-19 infection and anxiety levels among college students, with the aim of providing empirical evidence for post-pandemic mental health screening and health management in universities.MethodsThe study used…
An Evidence-Based AI Virtual Assistant for Young People With Attention Deficit Hyperactivity Disorder: Co-Design and Prototype Development
Background: Though attention deficit hyperactivity disorder (ADHD) is thought to be the most prevalent neurodevelopmental disorder in young people worldwide, there are inequalities in access to psychoeducation and health care support. One way to improve access, potentially increase engagement, reduce…
Tool or Companion? Reframing Conversational AI to Prevent Psychological Harm
People increasingly turn to conversational AI for companionship, emotional support, and well-being, using both purpose-built companion apps, such as Replika and Character.AI, and general-purpose assistants, such as ChatGPT and Claude. While some evidence suggests potential benefits, including short-term reductions in…