Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Renaclic for Chronic Kidney Disease Self-Management: Formative User-Centered Co-Design Study
Background: Chronic kidney disease (CKD) affects over 850 million individuals worldwide and requires sustained patient education, shared decision-making, and self-management support. Digital health platforms may facilitate these needs; however, many lack comprehensive, user-centered design and fail to address practical and…
Autistic traits and obsessive–compulsive symptom severity: a retrospective six-month follow-up study
Autistic traits have been increasingly associated with obsessive–compulsive disorder (OCD), yet their influence on longitudinal symptom severity and treatment-related change remains poorly understood. This retrospective longitudinal study included 38 adults with DSM-5 OCD who completed six months of guideline-based pharmacological…
Association of iron deficiency and iron-deficiency anemia with behavioral problems in children with autism: a cross-sectional study
PurposeIron deficiency (ID) and iron deficiency anemia (IDA) are common in children with autism spectrum disorder (ASD) and may contribute to behavioral problems. We examined their association with internalizing and externalizing behavioral problems.MethodsThis cross-sectional study (October 2023 to March 2025)…
Neurodiversity as an epistemic stress test for psychotherapy and health care: a neuroaffirmative conceptual analysis of relational-proximity priors in clinical, institutional, and AI-supported models
Neurodiversity-affirming mental health care requires not only adapting support to neurodivergent people but also examining the relational assumptions through which alliance, empathy, cooperation, progress, and risk are interpreted. This Conceptual Analysis develops the heuristic concept of relational-proximity priors: implicit assumptions…
Rapid Entrainment and Signal-guided Neuromodulation for Behavioral Health
Conditions: Anxiety; PTSD; ADHD; Depression Disorders; Post-traumatic Stress; Substance Use; Executive Function; Sleep Disturbance Interventions: Behavioral: AIP-Informed Integrative Psychotherapy; Device: Transcutaneous Auricular Vagus Nerve Stimulation; Behavioral: Regulated Breathing and Autonomic Regulation; Device: Audiovisual Entrainment; Device: Vibroacoustic Stimulation; Behavioral: Breathwork-Based Auditory…
Personalising ADHD Medication Treatment for Children and Young People
Conditions: ADHD Interventions: Other: PETRA decision-aid tool; Other: Best-evidence decision-support tool Sponsors: University of Southampton Not yet recruiting
Heart Rate Variability Biofeedback for Anxiety in Autistic Youth
Conditions: Autism Spectrum Disorder; Anxiety Interventions: Device: Lief Smart Patch Sponsors: Massachusetts General Hospital; Eagles Autism Foundation Not yet recruiting
Evaluating the Effects of StrongMinds Community-Based Group Interpersonal Therapy on Depression and Secondary Outcomes in Uganda
Conditions: Depression - Major Depressive Disorder Interventions: Behavioral: Group Interpersonal Therapy (IPT-G); Behavioral: Enhanced treatment as usual Sponsors: IDinsight; StrongMinds Active, not recruiting
Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis
Conditions: First Episode Psychosis (FEP); Psychosis; Schizophreni-form Disorder; Dependence Addictive Interventions: Other: CHAMPS; Other: I Can Change Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Integrated University Health and Social Services Center of the Capitale-Nationale; Nova Scotia Health Authority; Centre…
Facing Fears From Home: Development, Feasibility and Maximization of FobiApp
Conditions: Specific Phobia Interventions: Behavioral: FobiApp AR Exposure therapy, Self-administered augmented reality exposure for cockroach phobia; Behavioral: FobiApp AR Exposure therapy + ABM, Self- administered augmented reality exposure combined with attentional bias modification training for cockroach phobia. Sponsors: Universitat Jaume…
Nonlinear associations of BMI and body dissatisfaction with depression and an exploratory decomposition of the indirect association: a cross-sectional study of Chinese university students
ObjectiveThis study aimed to examine the non-linear associations of body mass index (BMI) and body dissatisfaction with depressive symptoms among Chinese university students, and to explore how the indirect association between BMI and depressive symptoms through body dissatisfaction varies across…
Building on Success: HEADSTRONG and The Inquiring Mind Transition to Jack.org
Ottawa, ON, September 9, 2026 – The Mental Health Commission of Canada is excited to announce that, effective September 8th, Jack.org will take over HEADSTRONG and The Inquiring Mind (TIM) to further increase the impact and growth of these programs…
Virtual Care Expansion and Physician Follow-Up Among Youth With First Mental Health Contact Through a Hospital: Population-Based Repeated Cross-Sectional Study
Background: Timely follow-up is crucial for youth whose first mental health contact is through a hospital; virtual care could facilitate this. Objective: This study aimed to examine the association between the significant expansion of virtual care in Ontario, Canada, and…
Video and App-Based Games for Youth Emotion Regulation: Scoping Review
Background: Emotion regulation (ER) is a transdiagnostic construct encompassing distinct strategies that can be used to encourage adaptive coping skills in support of youth’s (ages 10 to 24 years) mental health. ER is responsive to training and intervention, such as…
Autistic traits in unaffected first-degree relatives of individuals with schizophrenia and bipolar disorder: implications for shared familial neurodevelopmental vulnerability
BackgroundAutistic traits have increasingly been linked to schizophrenia (SCH) and bipolar disorder (BD) within a shared neurodevelopmental framework. However, whether these traits are similarly expressed in unaffected first-degree relatives of individuals with SCH and BD remains poorly understood.MethodsThis cross-sectional study…
Ketogenic therapy as a potential novel treatment approach for PTSD: an integrative review and proposed mechanistic model
BackgroundBrain and body metabolic disruptions have been suggested in several studies as a mechanism underlying posttraumatic stress disorder (PTSD). Therapies targeting metabolic pathways might provide new treatment options. This review explores the potential of ketogenic therapies, such as the ketogenic…
Telemedicine company offers GLP-1s for addiction
A CDC Covid restructuring, public trust in Fauci, and more health news from Morning Rounds
Investigating the DTI-ALPS index and its association with cognitive impairment in Alzheimer’s disease: a diffusion tensor imaging study
ObjectivesWith the global aging population, Alzheimer’s disease (AD) poses a major health challenge. The diffusion tensor image (DTI) analysis along the perivascular space (DTI-ALPS) index has emerged as a noninvasive imaging marker that indirectly reflects glymphatic function. However, its alterations…
Multimodal network alterations in diagnosis-age-defined early- and late-onset Alzheimer’s disease
IntroductionEarly-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) may differ in large-scale network organization. We compared multimodal MRI markers of diagnosis-age-defined Alzheimer’s phenotypes.MethodsAlzheimer’s Disease Neuroimaging Initiative participants were classified by age at first recorded mild cognitive impairment or Alzheimer’s…