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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Ethical and Legal Considerations in the Collection and Analysis of Mental Health Lived Experience Narratives: Reflections on 4 Case Studies of Research Practice
Personal narratives describing lived experiences of the entire spectrum of mental health challenges are now widely available to the public, including through autobiographies from public figures, thematic collections of narratives assembled by mental health organizations, and individual narratives published on…
Virtual Reality–Assisted Therapy Compared to Cognitive Behavioral Therapy for Patients With Treatment-Resistant Schizophrenia: Assessor-Blind Randomized Controlled Trial
Background: Auditory verbal hallucinations (AVH) are among the most disabling symptoms of schizophrenia and often persist despite treatment. Virtual reality–assisted therapies (VRTs) are a new generation of relational interventions for AVH, but comparative evidence against active interventions is currently lacking.…
Psychological Therapy in the Age of Large Language Models: Framework for Therapist-Delivered and AI-Supported Functions
Large language models are increasingly used within and alongside therapy. As large language models perform more therapy functions, questions arise about what the future might hold for therapists and what they will do. We argue that the enduring therapist role…
Human Cortical Organoids Expand Across a Cortex-Depleted Mouse Brain
A new xenocortication model enables human neurons to grow, form long-range projections, and integrate with host circuitry, removing major constraints on modeling human neuronal development and disease. The post Human Cortical Organoids Expand Across a Cortex-Depleted Mouse Brain appeared first…
Transcutaneous auricular vagus nerve stimulation targets the brain-gut axis to treat functional dyspepsia: a scoping review of clinical evidence and mechanistic research
BackgroundFunctional dyspepsia (FD) is a common gut–brain interaction disorder with suboptimal response to pharmacotherapy. Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive neuromodulation targeting the vagus nerve, has emerged as a promising brain–gut axis therapy. This scoping review (PRISMA-ScR, JBI…
Associations of weight change with perceived stress and depression: a nationwide population-based study
PurposeDepression and perceived stress are prevalent mental health problems worldwide, closely associated with physical health. Prior studies have suggested that both weight gain and loss may increase the odds of depression and stress, highlighting the need for clarification using national…
Efficacy of mindfulness-based interventions for children and adolescents with attention deficit hyperactivity disorder: a systematic review and meta-analysis
Background and objectiveAttention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood. Although mindfulness-based interventions (MBIs) have been proposed as promising non-pharmacological treatments, evidence regarding their efficacy in children and adolescents with ADHD remains inconsistent.MethodsA systematic search of…
Summary of current evidence for digital health interventions in the screening and management of postpartum depression
AimTo identify, appraise, summarise, and synthesise current evidence on digital health strategies for postpartum depression (PPD) screening and management, and to develop practice-oriented recommendations to support evidence-informed clinical nursing practice.MethodsUsing the 6S evidence hierarchy to guide the retrieval sequence, we…
Investigation of psychiatric symptoms, dissociative experiences, and childhood trauma in allergic rhinitis, and evaluation of the clinical relationship between these factors
BackgroundIn this study, we aimed to evaluate levels of depression and anxiety symptoms, childhood trauma, and dissociative experiences in patients with allergic rhinitis (AR) and compare them with healthy controls. Additionally, investigate the association between childhood trauma, depressive symptoms, and…
Leveraging Scalable Non-Mammalian Systems for Large-Scale Studies of Autism Risk Gene Function
There are over 100 large-effect genes strongly associated with autism spectrum disorder (ASD), yet advancing from risk genes to the discovery of common biological pathways and pharmacological targets remains a central challenge. Scalable non-mammalian systems, including Caenorhabditis elegans (roundworm), Drosophila…
A Smartphone-Based Acoustic Machine Learning Pipeline for Detecting Suicidal Ideation: Case-Control Model Development and Validation Study
Background: Suicidal ideation (SI) among university students is a growing public health concern. Self-report screening can be limited by concealment and delayed disclosure. We evaluated a leakage-resistant, proof-of-concept pipeline to detect SI from standardized smartphone-recorded speech. Objective: This study aimed…
SNF Global Center to Convene Second Global Summit on Youth Mental Health
Following the success of the inaugural summit, this year’s event will further bridge science, storytelling, and lived experience through breakout sessions, new research and evidence, interactive activations, networking, and notable guest appearances. The post SNF Global Center to Convene Second Global Summit…
Neural encoding of auditory processing in schizophrenia
IntroductionAuditory processing abnormalities are a core feature of schizophrenia and are linked to deficits in speech perception, cognitive function, and everyday communication. It remains unclear which stages of auditory processing are most disrupted and how these disruptions relate to symptoms…
Marital satisfaction and phubbing: the roles of depressive symptoms and subjective social status
BackgroundPrevious studies have mainly examined the associations between partner phubbing and relationship outcomes among phubbees, whereas less is known about how marital relationship quality is associated with phubbing among phubbers themselves. This study aims to examine the relationship between marital…
Association between perceived school climate and employment anxiety among medical undergraduates: the mediating role of intentional self-regulation and the moderating role of perceived employability
BackgroundEmployment anxiety is an important psychological concern for medical undergraduates during the transition from university to work. This study examined the association between perceived school climate and employment anxiety and evaluated the roles of intentional self-regulation and perceived employability in…
Developing Microbiome and Dietary Strategies Based on Chrono-nutrition for Targeting ADHD
Conditions: ADHD; ADHD - Attention Deficit Disorder With Hyperactivity Interventions: Behavioral: Circadian fasting Sponsors: Spanish National Research Council; Hospital Universitario Doctor Peset; Institute of Agrochemistry and Food Technology, National Research Council; State Research Agency, Spain Enrolling by invitation
Breaking the Cycle of Social Media Addiction: Efficacy of a 4-STEP Training Program in Reducing Cognitive Fatigue, Psychological Distress, Academic Procrastination, and Burnout Among Adolescents
Conditions: Social Media Addiction Interventions: Behavioral: 4-STEP-TPS Sponsors: Government College University Faisalabad Not yet recruiting
4-STEP Training Program for Social Media Addiction, Cognitive Fatigue, Psychological Distress, Academic Burnout and Procrastination Among Students
Conditions: Social Media Addiction Interventions: Behavioral: 4-STEP-TPS Sponsors: Government College University Faisalabad Not yet recruiting
Exploration of the relationship between social cognition and PTSD using data from the ALSPAC cohort
Background and hypothesisPrevious studies have shown an association between social cognition (emotion recognition, social perception, attributional style, and mentalization) and post-traumatic stress disorder (PTSD), but there have been no longitudinal studies on this topic. We hypothesize that childhood social cognitive…
Improving family functioning and wellbeing among families of children with disabilities in Rwanda: an application of the SAFE child protection model
BackgroundFamilies of children with disabilities in low-resource settings face heightened challenges to family functioning and wellbeing. Improving a child and caregiver’s environment in these settings requires a broader understanding of the family ecosystem. This study aims to investigate factors that…