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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Supporting Student Mental Health With the Safespace Generative AI Chatbot: Mixed Methods Feasibility Study
Background: Generative artificial intelligence (GenAI) chatbots have the potential to provide personalized mental health support to individuals at scale. Objective: This study evaluates the feasibility and usage patterns of the Safespace GenAI chatbot, an artificial intelligence (AI)–driven smartphone app that…
Global research landscape, knowledge structure, and emerging trends in adverse childhood experiences and personality disorders: a bibliometric analysis
BackgroundThe relationship between adverse childhood experiences (ACEs) and personality disorders (PDs) has attracted sustained attention in psychiatry, psychology, and public health. Existing studies have mainly examined epidemiological associations, specific PDs diagnoses, or mechanisms, whereas bibliometric evidence mapping the field’s knowledge…
Shared reading is associated with fewer emotional/behavioral problems and better prosocial behavior in preschool children: a cross-sectional study in western China
BackgroundThe home literacy environment, particularly shared reading, plays a critical role in preschool children’s cognitive and socioemotional development. However, its associations with emotional and behavioral problems remain underexplored in large-scale studies. This study examined the relationship between shared reading and…
Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children
Conditions: Attention Deficit Hyperactivity Disorder Interventions: Dietary Supplement: Inulin; Dietary Supplement: Probiotic; Dietary Supplement: Omega-3 Fatty Acids; Dietary Supplement: Thiamine; Other: Placebo Sponsors: Khyber Medical University Peshawar; Khyber Teaching Hospital Recruiting
Virtual Reality Headset as an Alternative Tool for Reducing Dental Anxiety
Conditions: Neurodevelopmental Disorder (Diagnosis) Interventions: Device: Virtual reality headset; Other: standard dental care Sponsors: Semmelweis University Enrolling by invitation
Dynamic changes of gut microbiota during progression of three Alzheimer’s disease mice models
IntroductionAlzheimer’s disease (AD) is an age-related and progressive neurodegenerative disorder characterized by cognitive impairment and irreversible neuronal degeneration, affecting approximately 55 million individuals worldwide. Despite extensive research efforts, the underlying pathogenic mechanisms of AD remain incompletely understood, and effective therapeutic…
Applications of machine learning algorithms to detect digital addiction: a meta-analysis
Digital addiction (DA) has emerged as a significant global concern, yet traditional diagnostic methods relying on self-report questionnaires face subjective bias and threshold inconsistencies. Recent advances in machine learning (ML) offer promising alternatives for automated DA detection. This study conducted…
Gender-specific symptom outcomes on cariprazine treatment: a 12-month naturalistic longitudinal follow-up study in schizophrenia
IntroductionA growing body of literature is focusing on third-generation antipsychotics and their unique characteristics, but few studies have examined gender as a crucial factor in response profiles. The present study aims to address this gap by analyzing the outcomes of…
Evaluation of Benign Joint Hypermobility and Serum Prolidase Levels in Children Diagnosed With Attention-Deficit/Hyperactivity Disorder (ADHD) Compared to Healthy Controls
Conditions: ADHD; Benign Joint Hypermobility Syndrome; ADHD - Attention Deficit Disorder With Hyperactivity; ADHD - Combined Type; ADHD - Inattentive Type Sponsors: Antalya Training and Research Hospital Completed
4-STEP-Training Program for Doomscrolling, Cyberchondriac Behavior and Psychiatric Symptoms (4-STEP-TPS) Among Individuals With Social Media Addiction
Conditions: Doomscrolling; Cyberchondriac Behavior; Social Media Addiction Interventions: Behavioral: 4-STEP-Training Program for Social Media Addiction (4-STEP-TPS) Sponsors: Government College University Faisalabad Not yet recruiting
Dog-Assisted Therapy in Adolescents Attending a Child and Adolescent Mental Health Day Hospital
Conditions: Mental Health Disorders in Adolescents; Emotional Dysregulation; Anxiety Disorders; Depressive Disorders; Eating Disorders Interventions: Behavioral: Experimental: Experimental: Dog-assisted therapy + Treatment as usual; Other: Active Comparator: Treatment as usual Sponsors: Hospital Clinic of Barcelona; Obra Social La Caixa, Spain…
Long‑Range Gene Networks Uncover 641 New Schizophrenia‑Associated Genes
A new gene‑network modeling framework integrating cis and trans regulatory effects identifies 766 schizophrenia‑associated genes—641 previously missed—across six brain regions. The post Long‑Range Gene Networks Uncover 641 New Schizophrenia‑Associated Genes appeared first on GEN - Genetic Engineering and Biotechnology News.
Gene Therapy Restores Brain Function and Behavior in Fragile X Syndrome
An AAV-based therapy carrying a normal human version of the FMR1 gene to produce the Fragile X messenger ribonucleoprotein (FMRP) found that early treatment normalized several measures of brain activity while improving social behavior, exploratory behavior, and cognitive flexibility. The…
Functional Outcome Prediction in Young Adults With Mental Health Symptoms Using Machine Learning and Large Language Models: Longitudinal Observational Study
Background: Functional impairments associated with mental health conditions are on the rise. Predicting functional outcomes may improve the targeting of preventive interventions. While prognostic models have primarily focused on psychosis, early recognition services require a transdiagnostic approach. Objective: This study…
When OCD Is Loud, Trust Your Higher Power
by Annabella Hagen, LCSW When I met Marie, she shared how faith and her connection with a Higher Power had always been important in her life. Her parents taught her... Read more » The post When OCD Is Loud, Trust…
The Role of Gender in Borderline Personality Disorder
Conditions: Borderline Personality Disorder (BPD) Sponsors: University Hospital Heidelberg Recruiting
Network analysis of spousal support and fear of childbirth in pregnant women of advanced maternal age
BackgroundFear of childbirth is an important perinatal mental health concern, particularly among women of advanced maternal age. However, the specific interrelations between spousal support and fear of childbirth remain unclear.MethodsThis cross-sectional study recruited 279 pregnant women of advanced maternal age…
Psychotherapy initiation is associated with discontinuation of psychotropic medications without dose escalation: a ten-year real-world cohort study (2014-2024)
BackgroundIncreasing psychotropic prescribing has raised concerns about long-term safety and regimen complexity in mental health care. Although psychotherapy is an established treatment, its role in medication optimization and psychotropic medication reduction in real-world practice across patient subgroups remains insufficiently characterized.ObjectiveTo…
Cognitive-attitudinal factors predict CBT-I enrollment willingness in Chinese sleep clinic patients: a knowledge-attitudes-practices survey
BackgroundDespite strong evidence for cognitive behavioral therapy for insomnia (CBT-I), uptake remains constrained by poorly understood cognitive, attitudinal, and practical barriers. This study examined determinants of willingness to enroll in sleep improvement programs among adults at risk of sleep disorders—including…
Brain-Infiltrating T Cells Linked to Social Deficits in Autism Mouse Model
Brain-infiltrating γδ T cells accumulate in a genetic autism mouse model, contributing to social deficits. Removing or blocking these immune cells improved sociability, highlighting immune dysregulation as a potential therapeutic target. The post Brain-Infiltrating T Cells Linked to Social Deficits…