Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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BFRBs vs. OCD: Similarities and Differences
This blog was originally posted by the TLC Foundation for BFRBs Body-focused repetitive behaviors (BFRBs) and obsessive-compulsive disorder (OCD) are two distinct mental health conditions that share some similarities but... Read more » The post BFRBs vs. OCD: Similarities and…
Verbal fluency after cochlear implantation: a longitudinal comparison with untreated hearing loss in the ELSA cohort
IntroductionHearing loss is associated with accelerated cognitive decline, and auditory rehabilitation via cochlear implantation (CI) may mitigate this trajectory. In the past, the impact of cochlear implantation on different cognitive subdomains has been described. However, verbal fluency (VF), which requires…
High perceived energy: exploring distinct patterns of energetic and cognitive functioning in older adults
BackgroundA hyperthymic temperament and high perceived energy are often framed as positive dispositional traits, particularly in later life. Indeed, these characteristics are generally associated with a greater tendency to preserve autonomy and with more favorable outcomes in terms of health,…
From promise to practice: artificial intelligence in mental health care in the MENA region
Mental health disorders represent a growing burden across the Middle East and North Africa (MENA) region, where depression and anxiety are highly prevalent amid conflict, displacement, and socioeconomic strain, affecting up to 40 percent of adults, yet treatment gaps remain…
Beyond Theory of Mind: mentalization as a relational and developmental framework for autism
Autistic individuals and those around them often navigate social and emotional situations in which behaviors, intentions, and affects are difficult to interpret. Supporting mentalizing processes within child–caregiver interactions may help address these challenges; however, a broader conceptual shift is needed,…
Construction and validation of multiple machine learning models for influencing factors of postpartum post-traumatic stress disorder in primiparas
ObjectiveTo analyze the multidimensional factors associated with postpartum post-traumatic stress disorder (PP-PTSD) in primiparas based on the Integrated Framework for Population Health Risk Management (IFPHRM), multiple machine learning-based predictive models were constructed and externally validated to identify high-risk individuals and…
Modeling Short-Term Symptom Changes and Behavioral Subtypes of Depression and Anxiety in the General Population: Observational Study Using Smartphone Data
Background: Smartphone-based digital phenotyping has emerged as a promising approach for monitoring mental health using passive behavioral data. Prior studies have linked smartphone-derived features to depression and anxiety severity; however, knowledge regarding whether short-term changes in symptoms can be captured…
Nonverbal AI-Based Communication Robot for Staff in Disaster-Affected Care Facilities: Exploratory ABAB Intervention Study
Background: Medical and welfare facilities in the Noto region of Japan were severely affected by the 2024 Noto Peninsula earthquake and subsequent torrential rains. Staff working in these facilities were disaster survivors and frontline caregivers with limited psychological support. Nonverbal…
Active Ingredients in Digital Cognitive Interventions: Integrating Dismantling Designs With Mechanistic Neuroscience
Digital cognitive interventions (DCIs) have emerged as scalable approaches for treating cognitive dysfunction across psychiatric, neurological, and aging populations. Despite growing evidence of efficacy, little is known about which intervention components drive therapeutic effects or through which neurocognitive mechanisms they…
Perception and willingness toward second-generation long-acting antipsychotics among patients with schizophrenia: a cross-sectional survey in Fujian, China
ObjectiveTo assess perceptions and willingness toward second-generation antipsychotic long-acting injectables (SGA-LAIs) among patients with schizophrenia, to identify the influencing factors, and to provide evidence for optimizing clinical implementation strategies.MethodsA cross-sectional survey was conducted in which patients with schizophrenia who attended…
A hybrid implementation-effectiveness study of a school-based intervention for promoting health and well-being in low-resource settings: the ISOBAR study protocol
IntroductionSchool-based interventions can improve adolescent health outcomes and tackle the growing burden of non-communicable diseases (NCDs) in low-and-middle-income countries (LMICs). Results to date are variable, partly due to lack of cultural adaptation of Westernised models and limited focus on implementation…
Coping styles and mental health outcomes in partners who have experienced a perinatal loss: a longitudinal study
Perinatal loss is common, but little is known about its impact on partners during the grieving process. This study examined psychological outcomes and coping strategies among recently bereaved partners (≤6 months post-loss; N = 73) at baseline (T1) and six-month follow-up (T2)…
Occupational burnout and risk of suicidality in healthcare professionals: a PRISMA-guided systematic review
BackgroundBurnout, an occupational phenomenon resulting from chronic workplace stress that has not been successfully managed, is increasingly recognized as a critical threat to the mental health of healthcare professionals. Prolonged exposure to work-related stressors may increase the risk of suicidality,…
TeleABA for Hospitalized Adolescents and Young Adults With Autism Spectrum Disorder
Conditions: Autism Spectrum Disorder (ASD) Interventions: Behavioral: Standard Hospital Care; Behavioral: Telehealth Applied Behavior Analysis (TeleABA) Sponsors: Caring Technologies, Inc.; National Institute of Mental Health (NIMH); Hackensack Meridian Health; Center for Social Dynamics; Rutgers University Not yet recruiting
Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder
Conditions: Major Depressive Disorder; Post-Traumatic Stress Disorder (PTSD) Interventions: Drug: Psilocybin; Behavioral: Structured Integrated Reframing Therapy (SIRT); Drug: Selective Serotonin Reuptake Inhibitor (SSRI) Sponsors: Khyber Medical University Peshawar; Hayatabad Medical Complex; KMU Institute of Health Science, Islamabad Recruiting
VR-Based Behavioral Activation in Adults
Conditions: Depression - Major Depressive Disorder; Behavioral Activation; Virtual Reality Therapy; Behavioral Inhibition Interventions: Device: Virtual Reality Behavioral Activation Software; Behavioral: Waitlist Control and Psychoeducation Sponsors: KTO Karatay University Completed
Digital Mindfulness-Based Therapy for Obsessive-Compulsive Disorder
Conditions: Obsessive-Compulsive Disorder Interventions: Behavioral: Digital Mindfulness-Based Therapy; Drug: Routine Pharmacological Treatment Sponsors: Central South University; Second Xiangya Hospital of Central South University Not yet recruiting
A Web-Based Self-Management Intervention for Return-to-Work Among Persons With Common Mental Disorders on Sick Leave: Case Study of mWorks
Background: mWorks is a co-designed, web-based self-management intervention developed to empower persons with common mental disorders who are on sick leave during the return-to-work process. However, limited knowledge of how mWorks is delivered and engaged with in real-world settings constrains…
Development and Formative Evaluation of a Narrative-Based Serious Game for Pregnancy Education: Mixed Methods Study
Background: Serious games are increasingly used in professional health education and maternal health promotion. However, most pregnancy-related digital interventions target specific behaviors and do not provide a comprehensive, longitudinal simulation of the pregnancy journey that incorporates psychosocial and administrative aspects.…
Perspectives on Remote Monitoring via Smartphones and Wearables Among Individuals With Lived Experience or at Risk of Eating Disorders (“This Could Go Very, Very Wrong”): Qualitative Interview Study
Background: Remote measurement technology (RMT) is increasingly used in health research to collect real-world data relevant to clinical states (eg, sleep, activity, and stress). Concerns exist about the impact of remote tracking via personal devices and wearables on individuals with…