Curated research, clinical and health-technology updates relevant to the communities and partners we work with.
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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Playing the Long Game for Youth Mental Health: A conversation with Grassroot Soccer on the power of sport and partnership
We spoke with Grassroot Soccer’s Mental Health Specialist Charmaine Nyakonda about the organization’s approach, the impact of their collaboration with SNF, and the growing role of sports in improving the mental health of young people and communities globally. The post…
Altered tryptophan metabolism as a contributor to cognitive impairment in chronic kidney disease: a narrative review
Approximately 40% of patients with chronic kidney disease (CKD) experience cognitive impairment (CI), which is strongly associated with increased mortality. CI is driven by multiple factors, including vascular injury, accumulation of uremic toxins, disruption of the blood–brain barrier, and chronic…
Physical education performance as a protective pathway: breaking the cycle between learning burnout and gaming disorder in Chinese adolescents
Background and AimsGaming disorder (GD) and learning burnout (LB) are critical issues impacting adolescents, with GD recognized by the World Health Organization as a behavioral addiction and LB contributing to academic disengagement. While prior research has examined bivariate relationships, such…
CD163+ perivascular macrophages in schizophrenia: a research framework for testing macrophage-related mechanisms
Elevated densities of CD163+ perivascular macrophages have been reported in schizophrenia post-mortem brain tissue, particularly in regions involved in neurodevelopment, dopaminergic signaling, and blood–brain barrier (BBB) regulation. However, the biological significance and developmental lineage of these findings remain unclear. While…
Pharmacotherapy, acupoint stimulation, and psychotherapy for perimenopausal women with anxiety, depression, and panic disorder: a systematic review and network meta-analysis of randomized controlled trials
BackgroundPerimenopausal women frequently experience physiological and psychological symptoms, including anxiety, depression, and panic disorders, mainly due to declining ovarian function and hormonal changes. Current options include pharmacotherapy, acupoint stimulation (AcuStim), and psychotherapy (psych), but their comparative efficacy and safety remain…
Opinion: MAHA is rewriting the vocabulary of American mental health care
“‘Deprescribing’ elevated into a movement, and a cultural default, is a clinical hazard,” writes Sunny Patel.
Evaluation of Foquest in Adults 65 Years and Older With ADHD
Conditions: Attention Deficit Hyperactivity Disorder Interventions: Drug: Methylphenidate hydrochloride extended-release capsules Sponsors: Dar Clinical Research Inc. Not yet recruiting
See, Blind Mice: Consortium’s Drugs Restore Sight
Researchers developed a series of light-activated small molecule drugs that mimic the function of the light-sensing photoreceptor cells that degenerate in diseases such as age-related macular degeneration and retinitis pigmentosa, and which in tests restored sight in blind mice. The…
A study on the relationship between research stress, research anxiety, research performance, and job satisfaction among Chinese healthcare professionals and its influencing mechanisms: a national multi-center survey
BackgroundChinese healthcare professionals face dual pressures from clinical duties and research activities, which may increase research-related anxiety and reduce job satisfaction. While occupational stress has been well studied, the mechanisms linking research stress to job satisfaction are unclear. Research performance…
ADHD as a disorder of operational capacity: a buffered-state framework for sustained engagement instability
Attention-deficit/hyperactivity disorder (ADHD) is commonly conceptualized as a disorder of executive dysfunction or impaired motivation. In clinical practice, however, many individuals with ADHD describe a different core difficulty: they can initiate tasks appropriately, understand goals, and exert effort, yet struggle…
Altered EEG microstate dynamics in adolescents with non-suicidal self-injury at rest and following acute social exclusion
BackgroundNon-suicidal self-injury (NSSI) is highly prevalent in adolescence, yet the fast dynamics of large-scale brain networks remain poorly understood. We aimed to characterize resting-state EEG microstate dynamics in a clinically recruited adolescent NSSI sample and to examine state-dependent changes following…
Fragile self, mechanical world: mechanistic delusions and ego fragility in schizotypal–affective spectrum disorder—a CARE case report
Categorical nosological systems frequently fall short when confronted with patients whose presentations cross established diagnostic boundaries. We report M.S., a 44-year-old Brazilian man involuntarily admitted to a psychiatric inpatient unit who presented with systematized persecutory ideation of mechanistic–technological content (chip…
Parent-Mediated Social Cognition Intervention for Young Children With Autism Spectrum Disorder
Conditions: Autism; Intervention (Training) Condition; Social Cognition; Cognition Improvement Interventions: Behavioral: Companion Mind-Drawing Cooperative Game Program Sponsors: Children's Hospital of Fudan University Recruiting
MyFILM: A Pilot Study for Social-Emotional Learning in Clinical Youth
Conditions: Mood Disorders; Anxiety Disorders Interventions: Behavioral: MyFILM Sponsors: Mark Sinyor Not yet recruiting
Academic burnout in higher education: a multimodal study of resting-state EEG microstate correlates beyond trait anxiety, depressive symptoms, and self-efficacy in Chinese undergraduates
BackgroundAcademic burnout is a mental-health-relevant outcome of higher-education stress, but its relationship with spontaneous brain dynamics remains unclear. EEG microstates are quasi-stable scalp-potential configurations indexing millisecond-level transitions between large-scale resting brain states. This study tested whether resting-state EEG microstate dynamics…
Social talk in virtual spaces: an observational study of pragmatic communication in children with autism spectrum disorder during avatar-mediated interaction
IntroductionImmersive virtual environments offer organized social contexts for the observation of communication behaviors under standardized and interactive conditions. This study adopts a VR-based observational approach to examine pragmatic social communication behaviors exhibited during structured social scenarios in autistic children, with…
Strategic Planning for a Digital Health Innovation Hub at a Saudi Academic Medical Center: Qualitative Case Study
Background: Rapid digital transformation is reshaping health care, but many digital initiatives struggle to deliver sustained organizational value when they are introduced as stand-alone technologies rather than as part of an institutional strategy. In Saudi Arabia, Vision 2030 has intensified…
A Self-Guided Mobile Mindfulness Intervention Embedded in Daily Routines for Adults With Mild to Moderate Psychological Distress: Randomized Controlled Trial
Background: Mobile mindfulness interventions have shown promise for reducing anxiety and depressive symptoms, but sustaining engagement remains a persistent challenge. Many digital programs still rely on formal practice that requires dedicated time, which may be difficult to integrate into daily…
enDigital Postpartum Support for Early Risk Identification Among Postpartum Women: Formative Randomized Evaluation and Exploratory Predictive Modeling Study
Background: The postpartum period represents a critical window for maternal health, yet many individuals lack sustained support and timely identification of physical and mental health risks. Digital health interventions offer a scalable approach to extend care beyond clinical settings. Yet,…
Blood Test Foresees Decline into Alzheimer’s Disease
Elevated levels of the blood-based biomarker phosphorylated tau 217 were associated with future cognitive decline in people who were previously unaffected by this, singling out those who might benefit most from disease-modifying treatments. The post Blood Test Foresees Decline into…