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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Very Low Uptake in Workplace Semen Analysis Research: Formative Web-Based Cross-Sectional Follow-Up Survey Distinguishing Employees With Self-Reported Unawareness From Aware Nonparticipants
Background: Very low uptake in workplace semen analysis research is difficult to interpret, particularly in employer-adjacent settings, where nonparticipation may reflect limited recruitment reach, limited understanding of the occupational rationale, low perceived relevance, or procedure-related concerns. Objective: This post hoc…
Autism-Related Information on Websites and General-Purpose Artificial Intelligence Chatbots: Comparative, Bilingual Study
Background: Parents increasingly consult the internet, both websites and, more recently, artificial intelligence chatbots, for information on autism spectrum disorder (ASD). However, the comparative quality of these two source types, especially across languages, remains underexplored. Objective: This study aimed to…
AI Agents Are Coming: 5-Stage Taxonomy of Language-Based AI Systems for Psychiatry, Psychotherapy, and Counseling
The rapid evolution of large language models has accelerated the development of agentic artificial intelligence (AI) systems capable of pursuing autonomous goals, creating an urgent need for structural frameworks in psychiatry and psychotherapy. While existing classifications often draw parallels to…
Attention-deficit/hyperactivity disorder and chronic pain: a scoping review of epidemiology, clinical phenotypes, mechanisms, and treatment
IntroductionEmerging evidence suggests a potential association between attention-deficit/hyperactivity disorder (ADHD) and chronic pain; however, extant findings are dispersed across disciplines and have not yet been comprehensively synthesized. This scoping review aimed to systematically map the epidemiological evidence, clinical phenotypes, proposed…
Family caregivers’ involvement in home-based recovery for patients with schizophrenia: a qualitative study in Beijing, China
BackgroundFamily caregivers play critical roles in supporting the home-based recovery of patients with schizophrenia, but they often encounter substantial challenges and receive insufficient systemic support. Understanding caregivers’ involvement in home-based recovery is essential for aligning community mental health services with…
Case Report: A novel de novo heterozygous truncating mutation in MED12L identified in a Chinese autistic boy
BackgroundAutism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder. A previous study by Nizon et al. indicated that some children with intellectual disability (ID) carrying de novo MED12L mutations exhibited mild to moderate autistic features. However, the relationship between MED12L…
STAT+: HHS presses ahead with effort to curb antidepressant use
In a private meeting, HHS officials met with mental health professionals to work on guidance for stopping SSRIs.
A Sensory-Profile Framework for Differentiated Swim Instruction in Autistic Children
Conditions: ASD Interventions: Behavioral: sensory-based instruction; Behavioral: standard instruction Sponsors: Genesis Indep Research Completed
HALO-TRIAL: High, Medium And LOw Intensity Psychotherapy for Binge Eating Disorder
Conditions: Binge Eating Disorder; Binge Eating Episodes; Binge Eating/Loss of Control Eating; Binge Eating Disorders; Binge Eating; Binge Eating Behaviour; Binge Eating Disorder Associated With Obesity; Eating Disorder Binge; Eating Disorders Interventions: Behavioral: Cognitive Behavioral Therapy Enhanced - Individual; Behavioral:…
Efficacy of a Gamified Blended Mindfulness Program to Reduce Burnout, Stress, and Anxiety in Nursing Students: A Randomized Controlled Trial
Conditions: Burnout Syndrome; Psychological Stress, Anxiety, and Depression Associated With Academic Pressure; Anxiety Interventions: Behavioral: Psychoeducation and Free App Recommendation; Behavioral: Standard Blended Mindfulness Program; Behavioral: Gamified Blended Mindfulness Program Sponsors: Universidad de Granada Completed
Digital Mental Health Research Priorities, Revisited for the AI and Large Language Model Era
Digital mental health has become an established part of mental health care, but the rapid arrival of large language models and other artificial intelligence tools has refocused attention on the evidence needed to guide the field. This editorial updates the…
Maintaining Emotional Boundaries as a Parent
Parents often emphasize to children the importance of respecting others’ boundaries — don’t tickle another kid if they say they don’t like it, for example. Don’t kiss someone unless they welcome it. But within the family, we can fail to…
How diet therapy affects obesity-associated depressive symptoms: from mechanism to therapeutics
Obesity stands as a formidable 21st-century public health crisis, with its capacity to aggravate depressive symptoms gaining increasing clinical attention. Traditional treatment models often treat these two conditions separately. However, recent research evidence suggests a complex network linking obesity and…
Prevalence of pharmacologically treated attention deficit hyperactivity disorder in children, adolescents, and adults: systematic review and meta-analysis
IntroductionAttention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental paediatric disorders and persists into adulthood, although it is frequently underdiagnosed and underrecognized in adult populations. In this context, the prevalence of pharmacologically treated individuals diagnosed with ADHD…
Efficacy of digital interventions in social anxiety disorder: a systematic review and Bayesian network meta-analysis
BackgroundSocial anxiety disorder (SAD) is characterized by a significant and persistent fear of social or performance situations. The prevalence of SAD has gradually increased recently, and the unique advantages of digital interventions (DIs) have gained traction in psychiatric disorders. However,…
The ECHO study: compassion-focused therapy for young voice hearers and their caregivers. A pilot study
BackgroundVoice hearing can occur in healthy people without a trigger, be caused by a traumatic event, or occur as part of a psychiatric disorder. There are still many gaps in our understanding of voice hearing, and research in this field…
New York boys club has a time-tested recipe to protect members’ mental health
At a time when attention is deservedly being turned to the mental health crisis in boys, the Boys' Club of New York is a shelter from the storm for many…
A novel mutation in SETD1A is associated with early-onset epilepsy—a rare case report
SET Domain Containing 1A (SETD1A) is a histone H3K4 methyltransferase implicated in neurodevelopmental disorders. Pathogenic variants in this gene are associated with schizophrenia, intellectual disability, and epilepsy. Here, whole-exome sequencing and Sanger sequencing were performed on a 4-year-old Chinese girl…
Local field potentials for target localization in centromedian deep brain stimulation for epilepsy
ObjectiveTo evaluate whether local field potential (LFP) spectral profiles can serve as a candidate “spectral fingerprint” for physiological confirmation of centromedian-parafascicular (CM–Pf) targeting during thalamic deep brain stimulation (DBS) for drug resistant epilepsy (DRE).MethodsThis is a retrospective study of 10…
Autistic- and attention-deficit/hyperactivity disorder-like traits: differential associations with burnout, depression and anxiety, and empathy among Japanese junior residents
IntroductionBurnout, depression, and anxiety are major concerns among physicians because they affect individual well-being, patient care, and healthcare systems. Neurodevelopmental traits, including autistic-like traits (ALTs) and attention-deficit/hyperactivity disorder (ADHD)-like traits (ADHLTs), may increase vulnerability to psychological distress. However, little is…