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Curcumin attenuates α-synuclein pathology in Parkinson’s disease model mice through modulation of UBC9-associated SUMOylation signaling

BackgroundPost-translational modifications, particularly SUMOylation, plays a crucial role in α-synuclein (α-syn) aggregation, a key pathological feature of Parkinson’s disease (PD). Curcumin, a natural polyphenol, has shown neuroprotective potential, but its effects on SUMOylation-related signaling in PD remain unclear.ObjectiveThis study aimed…

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Subcortical gray matter atrophy and iron deposition in patients with vascular dementia: a multimodal MRI study

PurposeVascular dementia (VAD) is the second most common type of dementia worldwide. Therefore, early detection and diagnosis, along with a clear understanding of its pathogenesis are critical for mitigating disease progression. In the present study, we aimed to elucidate the…

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Editorial: eHealth and personalized medicine in mental health and neurodevelopmental disorders: digital innovation for diagnosis, care, and clinical management

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Illness perception, family resilience, and emotional distress among hospitalized older adults with multimorbidity in Xinjiang, China: a latent profile and mediation analysis

BackgroundOlder adults with multimorbidity frequently encounter significant psychological challenges, with negative illness perception being a prevalent issue. Such perceptions can intensify emotional distress. Family resilience—the ability of a family system to adapt positively to adversity—plays a crucial role in alleviating…

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Remimazolam versus propofol on seizure adequacy in electroconvulsive therapy: a retrospective cohort study

ObjectiveElectroconvulsive therapy (ECT) is a core treatment modality for severe mental disorders, and the choice of anesthetic induction agent directly impacts seizure quality and therapeutic outcomes. This study aimed to compare the effects of remimazolam versus propofol on seizure adequacy…

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Latest developments in the use of e-cigarettes by people with schizophrenia spectrum disorders who smoke: a scoping review

BackgroundTobacco use is significantly more prevalent among individuals with schizophrenia spectrum disorders (SSD) compared to the general population, contributing to elevated rates of premature mortality from smoking-related diseases. Despite a decline in smoking prevalence in the general population, individuals with…

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A Study to Assess the Efficacy and Safety of Solriamfetol in Adolescents With ADHD

Conditions: ADHD Interventions: Drug: Solriamfetol Dose A; Drug: Solriamfetol Dose B; Drug: Placebo Sponsors: Axsome Therapeutics, Inc. Recruiting

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A Study to Assess the Efficacy and Safety of Solriamfetol in Children With ADHD

Conditions: ADHD Interventions: Drug: Solriamfetol Dose A; Drug: Solriamfetol Dose B; Drug: Placebo Sponsors: Axsome Therapeutics, Inc. Recruiting

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Home Play-based Intervention for Parents and Infants

Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD); Autism Spectrum Disorder; Premature Birth; Global Developmental Delay Interventions: Behavioral: SPRINT Intervention; Other: Waitlist Protocol Sponsors: Nanyang Technological University; Agency for Science, Technology and Research (A*STAR); KK Women's and Children's Hospital; Institute for Human Development and…

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Defining and Assessing Empathic Communication in Patient Portal Secure Messages: Adapted Coding Framework Development Study

Background: Empathic communication in the clinical setting has been associated with improved clinical outcomes, decreased anxiety, and increased patient satisfaction, treatment adherence, and trust. Despite the recent growth in patient portal use, the expression of empathic communication through patient portal…

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Protein Protects Against Tau Tangles, Synaptic Loss in Mouse Model of Tauopathy

Scientists found that upregulating a protein known as SORLA offers protection against the effects of tau tangles in a mouse model, pointing to a potential therapeutic strategy for tauopathies including Alzheimer’s disease. The post Protein Protects Against Tau Tangles, Synaptic…

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Integrating cognitive-behavioral training with immersive virtual reality intervention in ADHD: a case report

IntroductionAttention-Deficit/Hyperactivity Disorder (ADHD) is a condition characterized by persistent patterns of inattention and/or hyperactivity-impulsivity. This case highlights the potential benefit of integrating Immersive Virtual Reality (IVR) with cognitive-behavioral therapy (CBT) in the rehabilitation of a child with ADHD. It contributes…

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Thyroid-stimulating hormone, fasting blood glucose and suicidal ideation in Chinese adolescents with major depressive disorder: a cross-sectional study

BackgroundThyroid function and glycolipid metabolic alterations are often associated with major depressive disorder (MDD), yet their roles in suicide risk among adolescents with MDD remain unclear. This study aimed to investigate thyroid-stimulating hormone (TSH) levels, glycolipid metabolism parameters, and their…

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Effects of exercise interventions on executive function in autism spectrum disorder: a three-level meta-analytic review

ObjectiveThis study aimed to use a three-level meta-analysis to examine the effects of exercise interventions on executive function (EF) in children and adolescents with autism spectrum disorder (ASD), and to explore the relationship between exercise dose and intervention effects through…

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Combining Transcranial Magnetic Stimulation With Emotion Regulation Skills Training in Borderline Personality Disorder

Conditions: Borderline Personality Disorder (BPD) Interventions: Device: Transcranial Magnetic Stimulation (TMS); Behavioral: Emotion Regulation Skills Training Sponsors: Massachusetts General Hospital Not yet recruiting

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Transition Care for FEP

Conditions: Schizoaffective Disorders; Bipolar Disorder With Psychotic Features; Schizophrenia Disorders; Major Depressive Disorder With Psychotic Features; Psychosis NOS Interventions: Behavioral: Transition Care Team Sponsors: University of Chicago; Sidney R. Baer, Jr. Foundation Recruiting

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StockWatch: Lilly’s Up-to-$3.8B Deal for AtaiBeckley a Good Trip for Psychedelic Drugs, Analysts and Investors Agree

Eli Lilly agreed to acquire AtaiBeckley for up to $3.8 billion—of which Lilly will pay $2.8 billion upfront. The deal, set to close in the third quarter, expands Lilly’s neuroscience portfolio by adding AtaiBeckley's pipeline led by BPL-003 (mebufotenin benzoate).…

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Development and validation of the digital well-being scale using university students

IntroductionDigital technologies are central to university students' academic, social, and personal lives, offering opportunities for learning and connection while also introducing challenges such as distraction, emotional strain, and difficulties with self-regulation. Despite increasing interest in digital well-being, there is a…

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Immersive Technologies in Forensic Mental Health and Prison Settings: Scoping Review

Background: The application of immersive technologies, particularly virtual reality, has expanded rapidly across health care domains, including mental health, rehabilitation, and education. These technologies enable the creation of controlled, interactive, and ecologically valid environments that can support therapeutic interventions, skill…

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Effects of Social Media Narratives on Affective and Behavioral Responses to Menopause Content: Randomized Online Experimental Study

Background: Social media is an increasingly prominent channel for communicating menopause information and experiences, yet the affective and behavioral consequences of different narrative framings remain unclear. Objective: We examined how distress, normalizing, and transformative narratives influenced women’s immediate responses to…

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