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ARIA funding
We’re proud to share that Relatix Bio has applied for funding from the UK’s Advanced Research and Invention Agency (ARIA) under their Trust Everything, Everywhere programme. This initiative explores how trust can be built across the digital and physical worlds,…
Relatix Bio’s Vision for a Better Tomorrow
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Empathic Disorders: From Diagnosis to Care
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Long Term Follow-up of Mentalization-Based Treatment: Exploring Variability in Outcomes, Long-term Value and Experiences 10+ Year After Receiving MBT Day Hospital or MBT Intensive Outpatient
Conditions: Borderline Personality Disorder Sponsors: De Viersprong; Arkin Not yet recruiting
Research on the Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum Disorder
Conditions: Williams Syndrome; Autism Disorder Sponsors: Qilu Hospital of Shandong University Not yet recruiting
Impact of an Educational Program on Teachers’ Knowledge and Classroom Performance Regarding ADHD
Conditions: ADHD - Attention Deficit Disorder With Hyperactivity Interventions: Behavioral: ADHD Educational Program for Primary School Teachers Sponsors: Dlniya Ismail Rashid Active, not recruiting
The Unspoken Toll: Why Exam Pressure Must Be Part of the Youth Mental Health Discussion
A Conversation with Tatum Redmond and Amanda van der Vyver-Anderson from Community Keepers, South Africa By Mai El Shoush, Partnerships Campaign Manager, Stavros Niarchos Foundation (SNF) Global Center for Child and Adolescent Mental Health at the Child Mind Institute Community…
Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis: A Micro-Randomized Trial
Conditions: Psychosis; Anxiety; Depression; Rumination Interventions: Behavioral: Smartphone-based Mindfulness Exercise; Behavioral: Smartphone-based Psychoeducation; Behavioral: Neutral Control Message Sponsors: Mclean Hospital Not yet recruiting
Safety Planning Intervention for Autistic Youth: A Randomized Controlled Trial With Providers in Developmental-Behavioral Pediatric Clinics
Conditions: Autism; Suicide Prevention Interventions: Behavioral: Safety Planning Intervention; Behavioral: Crisis Interventions for Pediatric Providers - Autism version (CIPP-A) Sponsors: Children's Hospital Los Angeles; Children's Hospital of Philadelphia Not yet recruiting
GLP-1 Receptor Agonists in Psychiatry: A Pharmacoepidemiological Scoping Review
Pharmacoepidemiological studies have expanded the capacity to detect therapeutic benefits and adverse drug effects of medications. In the case of glucagon-like peptide-1 receptor agonists (GLP-1RAs), their fast uptake for treating diabetes and obesity has generated substantial real-world experience, facilitating exploration…
AI Chatbots for Mental Health Self-Management: Lived Experience–Centered Qualitative Study
Background: Large language models (LLMs) now enable chatbots to engage in sensitive mental health conversations, including depression self-management. Yet their rapid deployment often overlooks how well these tools align with the priorities of people with lived experiences, which can introduce…
Impact of abnormal metabolic-immunoinflammatory pathway on splenomegaly in patients with chronic schizophrenia and exploration of risk factors: case-control study
ObjectiveThis study aimed to identify risk factors for splenomegaly in chronic schizophrenia patients and clarify associations among metabolic−immunoinflammatory pathways, psychiatric symptoms and splenomegaly. The findings will help optimize somatic monitoring and intervention strategies.MethodsA case−control design was used. A total of…
Beyond dopamine blockade: mechanistic humility and the rise of muscarinic, TAAR1, and glutamatergic pathways in schizophrenia
The approval of the first non–dopamine-blocking therapy for schizophrenia marks a defining moment in psychiatry. Muscarinic M1/M4 modulation, alongside emerging TAAR1 and glutamatergic pathways, signals a shift beyond dopamine dominance toward circuit-level integration. These advances embody mechanistic humility: the scientific…
Digital Health Coffee Time Briefing ☕
Today's briefing features a free digital platform built for unpaid carers in the UK and an AI-enabled platform for eating disorder services.
What The Atlantic Missed About OCD: There Is Hope
Dear Editor, The Atlantic’s recent article, “When Mentally Ill Teenagers Ask to Be Put to Death,” brings needed attention to the profound and often misunderstood suffering caused by obsessive compulsive... Read more » The post What The Atlantic Missed About…
IOCDF Calls for Reinstatement of SAMHSA Grants, Renewed Commitment to Mental Health Support
The International OCD Foundation is alarmed by the apparent sudden and widespread termination of grants supporting vital mental health and addiction services previously funded through the U.S. Substance Abuse and... Read more » The post IOCDF Calls for Reinstatement of…
Facing the Monster: My Journey Living with OCD and Finding Hope
by David Kedeme I remember the day my white high top Puma sneakers my parents gifted me for Christmas became the exact opposite of the color they came boxed in.... Read more » The post Facing the Monster: My Journey…
Attenuation of mGluR1/5-dependent synaptic plasticity and ERK pathway dysfunction in the hippocampus of diabetic rats
Streptozotocin-induced diabetic rats (STZ rats), an established animal model of type 1 diabetes mellitus, develop cognitive decline, which has been linked to impairments in hippocampal synaptic plasticity. Long-term depression (LTD) in the hippocampus may be induced by the activation of…
Commercial or industrial use of mental health data for research: primer and best-practice guidelines from the DATAMIND patient/public Lived Experience Advisory Group
BackgroundRoutinely collected health data, such as that held by United Kingdom (UK) national health services (NHS), has important research uses. However, its use requires public trust and transparency. Access by commercial/industrial organisations is especially sensitive for the public, as is…
Synergies in psychedelic-assisted therapy: a qualitative interview study of psychotherapeutic processes
Research on the therapeutic effects of psychedelics in psychiatry, commonly referred to as Psychedelic-Assisted Therapy (PAT), has expanded substantially in recent years. The context-dependent nature of psychedelics has sparked discussion about the importance of the psychotherapeutic environment in achieving beneficial…
Asking for help: the development of a simulation-based mental health application to enhance depression literacy, mental health communication, and help-seeking among Black autistic youth
Black autistic youth experience disproportionately high rates of depression and face intersecting barriers such as racial discrimination, stigma, and limited access to care, yet few interventions address their needs. This study introduces Asking for Help (A4H), a culturally responsive, simulation-based…
Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics
Trauma can contribute to lasting psychological, behavioral, and physiological effects that extend across generations. Intergenerational trauma refers to trauma-related effects observed in children of exposed parents, while transgenerational trauma describes effects observed in later generations without direct exposure. Proposed mechanisms…