Teclistamab-based induction treatment in transplant-eligible, newly diagnosed multiple myeloma: a phase 2 trial

Nature Medicine, Published online: 25 June 2026; doi:10.1038/s41591-026-04471-x

In the ongoing phase 2 GMMG-HD10/DSMM-XX (MajesTEC-5) trial in patients with transplant-eligible, newly diagnosed multiple myeloma, induction with the BCMA×CD3 bispecific engager teclistamab in combination with daratumumab plus lenalidomide, with or without bortezomib, had a similar toxicity profile to other bispecific regimens with an encouraging and deep response rate.

DBS: from neuromodulation to neuroremodelling

Nature Neuroscience, Published online: 25 June 2026; doi:10.1038/s41593-026-02347-4

Deep-brain stimulation (DBS) treats movement and neuropsychiatric disorders through mechanisms that remain unclear. Two studies that combine longitudinal neuroimaging, stimulation experiments and tissue-level analysis show that the effects of DBS evolve in space and time, demonstrating acute effects on network activity as well as providing insights into chronic effects that reshape the networks it engages.

InduPro Licenses Lonza’s Linker Payload Technologies and Bioconjugation Platforms

Lonza and InduPro signed a licensing agreement to support the advancement of innovative antibody–drug conjugate (ADC) therapies. According to Lonza officials, the company, through one of its affiliated companies, will grant InduPro a non-exclusive, worldwide license to its proprietary GlycoConnect®, HydraSpace® and linker-payload technologies. The technologies, which will be applied to the development of ADCs targeting up to two oncology antigens, are intended to support the advancement of highly targeted cancer therapies.

InduPro will combine its proprietary bispecific antibody capabilities with Lonza’s ADC platform. By leveraging these complementary technologies, the companies aim to develop differentiated therapeutic approaches designed to address complex diseases such as cancer, where precision targeting and efficacy remain critically important, notes Jan Vertommen, vice president of commercial development, advanced synthesis, Lonza.

“By combining our expertise in bioconjugation technologies and manufacturing with InduPro’s innovative proximity guided antibody platform, we reinforce our commitment to enabling our licensing partners and supporting the advancement of next-generation ADC programs,” says Vertommen.

“This agreement represents an important step in advancing our pipeline of proximity-driven bispecific ADCs,” adds Prakash Raman, CEO, InduPro. “By combining InduPro’s ability to identify novel, disease-specific co-target pairs with Lonza’s industry-leading ADC technologies, we aim to develop differentiated, first-in-class therapeutics that improve selectivity, expand therapeutic windows, and ultimately deliver better outcomes for patients with hard-to-treat tumors.”

The post InduPro Licenses Lonza’s Linker Payload Technologies and Bioconjugation Platforms appeared first on GEN – Genetic Engineering and Biotechnology News.

STAT+: FDA gives generative AI in radiology two breakthrough designation nods

The Food and Drug Administration has granted breakthrough designation to two devices that use generative AI to interpret chest X-rays and draft the radiology reports typically written by human radiologists.

Machine learning systems have long analyzed images like X-rays and CT scans. But more recently, large vision language models have ushered in a new capability. Instead of highlighting a spot for a radiologist to review and write up, generative AI can process the entire image and draft many of its findings for a radiologist to review — a technological advancement that is challenging traditional validation and regulatory frameworks. 

In March, one breakthrough designation went to Cognita, a Stanford researcher-founded startup acquired late last year by the large radiology practice Radiology Partners. Radiology AI company Aidoc announced its own breakthrough designation Thursday for a tool called First Read, specifically when it is used to detect and describe four life-threatening findings. 

Continue to STAT+ to read the full story…

IBM has unveiled chip technology that could help extend Moore’s Law another decade

IBM has built a new prototype chip with around 100 billion transistors on an area the size of a fingernail, which is twice the density of the company’s previous state-of-the-art technology announced in 2021. The design could pave the way for faster and more energy efficient computers for years to come.

For more than half a century, chipmakers have been able to make ever more powerful computers by following the key principle of Moore’s Law: Cram more transistors onto the chip. To do this, they shrank transistors—the tiny switches that perform computations—to incrementally smaller sizes. But in the last 15 years, transistors have gotten close to the point where quantum mechanics starts to interfere with their function: just a few dozen nanometers in size. They can’t get smaller.

So to fit more transistors on a chip, engineers across the industry are eyeing a pivot to an approach familiar to urban planners: build up. On Thursday, IBM announced it has created a chip that uses this strategy. The new architecture, known as a nanostack, vertically stacks transistors in two layers on a silicon chip.

“It’s not just an incremental step,” Jay Gambetta, the director of IBM Research, said during a press conference on Tuesday. “It’s a meaningful leap forward.” Within a decade, Gambetta expects, chips with nanostacking will be widely used in data centers, where their improved efficiency could help the facilities better manage their energy consumption.

“Absolutely, it’s transformational,” says Dan Hutcheson, vice chair of TechInsights, a technology analysis company. “This puts another 10, 15 years on the roadmap.” 

Compared with IBM’s previous state-of-the-art architecture, the company reports, chips built with this new approach can do as much as 50% more work in the same amount of time and be up to 70% more energy efficient. 

The architecture offers a general way of laying out transistors, and IBM will partner with semiconductor manufacturers to make the actual chips. It anticipates that chip designers will deploy the design in many different types of chips, including GPUs and CPUs. “I expect to have many conversations with designers about how they can use this technology,” Huiming Bu, IBM’s vice president of global semiconductor R&D, said in the press conference announcing the new design. 

A layer cake

Engineers created IBM’s new chip layer by layer, like a cake. They start by fabricating transistors on one layer of silicon. Then they place a silicon layer on top of these devices, and they fabricate another layer of transistors directly on top of that. Finally, they create the electrical connections between the two layers of transistors. This kind of vertical stack, which combines two types of transistors, is known as a complementary field-effect transistor, or CFET, explains Qing Cao, a professor of materials science and engineering at the University of Illinois at Urbana-Champaign, who was not involved with the work. 

The company isn’t the only one pursuing this general approach. The biggest chip manufacturers—Intel, Samsung, and TSMC—and the competing research lab Imec in Belgium have been investigating CFETs. IBM says its design is distinguished by the fact that the transistors in the second layer do not sit directly on top of the first layer’s transistors; rather, they are staggered, which the company says simplifies wiring, among other advantages. 

CFETs like those in IBM’s nanostack architecture contrast with another common approach to making two-tiered chips, such as AMD’s 3D V-Cache and Huawei’s forthcoming LogicFolding technology, Cao says. In those approaches, engineers fabricate the transistors on each layer of the chip independently before bonding the two together. IBM’s new method allows for more precise alignment of the layers, which is important for performance because transistors are so tiny, says Cao. 

Nanostacking builds on an approach called nanosheet technology, which has been used to make current state-of-the-art transistors since around 2022. A transistor is essentially a hose through which electrons flow, with a valve that can turn the flow on or off. Inside the transistor, electrons move through a patch of the silicon called a channel. In IBM’s nanostack approach, the channel consists of three nanosheets that are each 15 atoms thick, spaced nine nanometers apart. 

Every chip generation gets a name. IBM refers to its nanostack technology as “sub-nanometer” or “0.7 nanometer,” following a longtime industry convention where each generation is named for a smaller and smaller length. But “0.7 nanometer” is a marketing term and does not correspond to any physical characteristics of the chip. The distance between transistors “has been staying at about 40 nanometers for quite a long period of time,” says Cao. 

Putting it into production

Looking ahead, chipmakers can try increasing transistor density by building on more tiers, as Bu suggested in the press conference. However, they will face practical challenges, according to Cao. Manufacturing introduces errors, which means a certain number of chips are faulty upon creation. “Here you’re building another layer on top, so if either top layer or bottom layer fail, your entire chip is going to fail,” says Cao. The resulting failure rate will be higher than for single-layer chips, and that will be costly.

Another central challenge is what Cao calls “the thermal budget.” Essentially, it means that engineers need to figure out how to build each layer without melting the connections to the one underneath. This means keeping manufacturing processes below 400 °C. IBM figured out how to make the second stack at low enough temperature, although the company is mum about its methods. 

Academics are also on the case. Cao’s group, for example, has created a method for stacking transistors layer by layer where the second layer is created with processes below 200 °C. They manage this by using a type of transistor known as the junctionless transistor, which can be created without a typically required step called doping—a process that injects non-silicon atoms into silicon to tune the material’s properties. Doping is usually the hottest part of fabricating transistors. Cao thinks from a thermal management perspective, his approach could be easier to scale up to multiple tiers, although his demonstration is just a proof of principle.

But Cao thinks IBM’s work is “transformative” because it demonstrates how to stack transistors “on a full wafer using a state‑of‑the‑art manufacturing line.” The new approach pushes the industry forward, he says: “I’m interested in what’s their killer application.”

What Europe’s heat wave means for the power grid

It’s been hard to look away from headlines about the European heat wave this week. Temperatures are breaking records across the continent, and the weather is threatening lives, shutting down schools, and in one particularly ironic case, forcing the cancellation of a London Climate Action Week event about extreme heat

As the summer ramps up and we see this kind of weather sweep around the Northern Hemisphere, I’m always keeping my eye on the power grid. And one notable update that caught my attention this week was news that a nuclear power plant in the south of France had to close down because of the heat

Climate change is squeezing the grid from all sides, affecting both supply and demand. Heat can affect power availability, from generation to transmission infrastructure, as I covered in my latest story. But climate change is also helping push electricity use higher—and countries in Europe and around the world will need to adapt. 

In the US, nearly 90% of homes have air-conditioning. That means many grids see their highest demand in the summer months, and the risk of brownouts and blackouts is at its worst. 

People are often quick to cast air-conditioning as a villain, and it’s true that the technology will account for a major chunk of the globe’s rising energy demand in the future. But the reality is that heat waves can be incredibly dangerous, and as climate change pushes temperatures higher, that risk is becoming more real in parts of the world that haven’t historically had to worry quite so much about heat. 

In Europe, air-conditioning is historically much less common, with about 20% of homes across the continent using it. Some countries, including those getting hit by this heat wave, have even lower rates—the UK comes in at about 5%, and Germany is around 3%. 

But those numbers are starting to tick up as people adapt to increasingly brutal summers. As they do, we should expect higher electricity demand, and stress for the grid—just as in the US. And utilities often have to look across borders to buy more power, driving prices up for everyone. 

“The main pressure comes from a triple squeeze: Cooling demand rises sharply, while power plants and grids become less efficient, and some thermal and nuclear plants must cut output because cooling water is too warm or scarce,” says Simone Tagliapietra, senior fellow at Bruegel, an economic and policy think tank, via email. 

Grid planning in the age of climate change generally means that we need a lot more supply, and quickly. But one interesting facet to this challenge is that in some places, seasonal patterns are shifting, compounding the difficulty of meeting demand. 

Generally, grid operators plan maintenance and outages at power plants around expected  peaks in demand. Take nuclear power, for example. In the US, planned outages for maintenance and refueling tend to come in the spring and fall when demand falls below the summer and slightly smaller winter peaks. 

Europe, however, has historically seen its grid peak in the winter, because electric heating is more common than air-conditioning. So some planned outages happen in the spring and into the summer, which is affecting the supply right now. 

At the Golfech power plant near Toulouse in France, for example, unit two had to shut down this week because of the water temperatures in the nearby river, which is used to cool the reactor. But unit one was already offline because of planned maintenance and refueling, according to EDF, the plant’s operator. 

We’re going to continue to see record-high temperatures around the world because of climate change. Communities are adapting, and utilities will have to follow. And if you thought this summer was hot, just wait until next year. With the El Niño weather pattern, 2027 could very well blow these heat waves out of the water. 

This article is from The Spark, MIT Technology Review’s weekly climate newsletter. To receive it in your inbox every Wednesday, sign up here.