New Research Calls for Stronger Standards When Using Large Language Models and Other AI Tools for Psychological Assessment

Researchers find AI models can score well on accuracy measures while missing key signs of mental health concerns; they introduce Text Psychometrics, a new framework for testing these tools more rigorously.

New York, NY — Today the Child Mind Institute, in collaboration with Harvard University and the Massachusetts Institute of Technology, released a new research paper that found that AI tools cannot yet provide valid psychological assessments and require a more rigorous testing process. The paper reaffirms that mental health professionals are still best suited to assess and address the needs of people seeking mental health resources. Additionally, researchers introduced a framework for evaluating whether AI systems can measure mental health in a scientifically sound, reliable, and fair way for future development. The paper is in press at PLOS Digital Health.

Every day, people describe their inner lives in text — including crisis hotline messages, social media posts, therapy transcripts, journal entries, and more. As AI becomes increasingly capable of analyzing language, researchers are beginning to use these tools as a new way to conduct psychological assessments.

However, unlike traditional questionnaires used by psychologists, most AI language tools are insufficiently tested. Experts have spent a century building rigorous statistical standards for questionnaires within the field of psychometrics. Does a test measure what it claims? Does it give consistent answers? And does it work equally well for everyone? AI language tools are rarely held to that same standard.

In this paper, researchers introduce the concept of Text Psychometrics, a framework for evaluating whether AI and natural language processing (NLP) tools can measure psychological constructs in text in a scientifically sound way. Rather than asking only whether a model can match human judgments, the co-authors argue that researchers should also examine whether these tools capture the full range of how people express symptoms, remain reliable across different psychological situations, and work fairly across different patient populations.

“This research reaffirms that AI cannot replace mental health professionals to adequately assess and meet the needs of patients and people seeking mental health resources. An AI model may appear accurate while still missing important ways people express psychological symptoms,” says Daniel Low, PhD, a research scientist at the Child Mind Institute and the study’s lead author. “AI can help researchers and clinicians analyze language at scale and find patterns that would otherwise be very challenging, but these AI models do not currently understand the full approach that experienced clinicians take when making assessments. With our new framework, our goal is not to replace human expertise, but to build tools that are helpful while being more transparent, trustworthy, and scientifically grounded to meet the needs of patients.”

To develop the paper and framework, researchers analyzed thousands of crisis counseling conversations and public social media posts. They compared several approaches for identifying mental health concerns, including large language models and other language-analysis methods. The team found that some AI systems performed well, on average, with commonly used accuracy measures. But they still failed to recognize many clear and important expressions of mental health concerns because they were less common and therefore did not affect the general accuracy. In other words, a model could appear successful while overlooking language that a clinician or researcher would consider highly relevant.

To address this issue, the researchers developed a new framework to evaluate language models that includes different types of validation, including what they call “content validity test sets.” Rather than asking only whether a model agrees with human judgments, the approach examines whether the model recognizes the full range of ways people express a psychological symptom. For example, to screen for eating disorders, a model would need to not only capture mentions of anorexia and bulimia but also purging, chewing and spitting, and other symptoms. 

“A mental health model should not be considered trustworthy simply because it performs well on a single metric,” Dr. Low explains. “Researchers should also ask whether it captures the most important expressions of a symptom, performs consistently, protects privacy, and works fairly across different groups of people, among many other desirable properties we describe.”

In a second study, the team examined whether language from the beginning of a crisis counseling conversation could predict who would later be sent an emergency service intervention towards the end of the conversation. The researchers found that language patterns associated with suicide risk could provide useful signals, while also revealing which factors out of about 50 were most strongly linked to acute risk. Mentions of lethal means for suicide, substance use and overdose, and having the texter write more than the counselor were the most predictive variables for detecting the need for an emergency service intervention.

Human clinicians consider far more than written words when evaluating a person’s mental health, including clinical history, life circumstances, nonverbal cues — if available — and professional judgment. The findings suggest that AI systems are not yet at this level.

The researchers hope Text Psychometrics will help consolidate efforts to improve how AI-based mental health assessments are developed and evaluated. By applying the same rigorous standards used for traditional psychological tests, they believe language-based AI tools can become more reliable, interpretable, and useful for research, clinical care, and public health.

The study was authored by Daniel Low, PhD, Patrick Mair, PhD, and Matthew K. Nock, PhD, of Harvard University, and Satrajit S. Ghosh, PhD, of the Massachusetts Institute of Technology and Harvard Medical School.

The research was supported by training grants from the National Institute of Mental Health and the National Institute on Deafness and Other Communication Disorders. It also received support from the RallyPoint Fellowship, Amelia Peabody Professional Development Award, Chet and Will Griswold Fund, Tommy Fuss Collaborative STAR Fund, and Lann and Christopher Woehrle Psychiatric Research Fund. The funders had no role in the study’s design, data collection and analysis, publication decision, or manuscript preparation.

The authors thank Crisis Text Line for providing access to de-identified data used in this research. Crisis Text Line did not influence the study design, analysis, interpretation of findings, or conclusions.

Learn More About Our Work

Learn more about the AI, Risk, and Contemplative Science (ARC) Lab and the Center for Data Analytics, Innovation, and Rigor (DAIR) at the Child Mind Institute.

Crisis Resources

If you or someone you know is struggling or in crisis:

Call or text 988 anytime in the United States to reach the Suicide & Crisis Lifeline

To reach Crisis Text Line, text HOME or HOLA to 741741 to connect with a live, trained volunteer crisis counselor.

About the Child Mind Institute

The Child Mind Institute is dedicated to transforming the lives of children and families struggling with mental health and learning disorders by giving them the help they need. We’ve become the leading independent nonprofit in children’s mental health by providing gold-standard, evidence-based care, delivering educational resources to millions of families each year, training educators in underserved communities, and developing tomorrow’s breakthrough treatments.

The post New Research Calls for Stronger Standards When Using Large Language Models and Other AI Tools for Psychological Assessment appeared first on Child Mind Institute.

Studies Using the Multiphase Optimization Strategy in Digital Mental Health: Scoping Review

Background: Improving the cost-effectiveness and scalability of mental health interventions remains challenging. The Multiphase Optimization Strategy (MOST) framework provides a structured approach for developing, optimizing, and evaluating behavioral interventions by balancing effectiveness with efficiency, economy, and scalability. It does so across 3 phases: preparation (theoretical grounding and component selection), optimization (experimental testing), and evaluation (confirmatory trial). Digital mental health interventions are especially suited to this modular approach, as they enable researchers to easily manipulate components and personalize delivery. Objective: This study aims to examine how the MOST framework has been applied in the digital mental health field and to provide recommendations for future application. Methods: Systematic searches were conducted in Embase, CINAHL, Web of Science, PsycInfo, and PubMed. Papers were included if they used the MOST to develop or optimize a digitally delivered mental health intervention. Studies targeting children aged under 12 years, reviews, and theoretical or simulated applications were excluded. Results: Thirty-seven papers representing 18 research projects met the inclusion criteria. The preparation phase was often incomplete and inconsistently reported, with optimization criteria largely absent and conceptual models often lacking specificity. Eight projects completed at least 1 optimization trial, typically using factorial designs, but progression to intervention refinement or evaluation was limited. Projects conducting multiple optimization rounds were more likely to achieve an optimized intervention. Conclusions: The MOST is increasingly applied in digital mental health research but often only partially implemented. While factorial designs are widely adopted, critical preparatory elements are frequently missing. To fully realize the MOST’s potential, future research should emphasize comprehensive application across all phases, iterative refinement, and transparent reporting.
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New addiction society guidance on medetomidine’s brutal withdrawal

Clinicians first noticed medetomidine in the Philadelphia drug supply during the spring of 2024. There was a cluster of overdoses one weekend, leaving patients more sedated and with lower heart rates than normal after receiving the reversal medication naloxone. 

It raised some red flags, but amid a constantly changing drug supply, not many. None of the patients died, and most went home from the hospital the same day. It wasn’t until autumn, when patients started coming in with excruciating withdrawal symptoms, that doctors knew something had dangerously shifted. 

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Relational Ecological Momentary Assessment: A Viewpoint on the Relational Decision Space in Digital Mental Health

Digital mental health has become increasingly capable of representing and adapting to individuals in time. When support is delivered through another person, however, the relevant decision context includes conditions that cannot be specified from the primary user alone. This viewpoint proposes making selected conditions relevant to a support decision within a specified relationship explicit. We introduce relational ecological momentary assessment (REMA) as a conceptual method for representing these conditions in a relational decision space. In its initial dyadic implementation, REMA combines a low-burden report of the primary user’s emotional zone (Z) with supporter contact availability (Cp) and supporter capacity (Cs). The meaning of these reports depends on the relationship and the proposed form of support. Willingness, consent, and safety determine whether an action is permissible to consider, while data validity concerns whether the reports are current and interpretable. These conditions and rules delimit relational support eligibility by specifying which classes of support can still be considered. Coregulation as a reciprocal temporal process remains outside the scope of this implementation. We situate the proposal within research on ecological momentary assessment, just-in-time adaptive interventions, dyadic digital health, and systemic digital mental health; provide a hypothetical implementation example; and show how 1 Z report can inform separate decisions involving different supporters. REMA remains conceptual and requires empirical evaluation. Its broader proposition is that when digital health recruits another person, the decision-relevant conditions across that specified relationship should be made explicit.
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Multimodal fMRI and DTI correlates of affective symptoms in diarrhea-predominant irritable bowel syndrome: a subtype-focused neuroimaging study

ObjectiveTo investigate brain structural and functional alterations in diarrhea-predominant irritable bowel syndrome (IBS-D) and their associations with affective symptoms using multimodal magnetic resonance imaging (MRI).Methods53 IBS-D patients and 55 healthy controls (HCs) underwent resting-state functional MRI (rs-fMRI) and diffusion tensor imaging (DTI). Rs-fMRI data were analyzed using fractional amplitude of low-frequency fluctuation (fALFF), z-transformed regional homogeneity (zReHo), and functional connectivity (FC). For DTI data, we extracted fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) under the tract-based spatial statistics (TBSS) framework. Inter-group comparisons of rs-fMRI metrics used FDR correction (q < 0.05), whereas DTI metrics were compared using non-parametric permutation testing with TFCE correction (p < 0.05). Abnormal imaging metrics were correlated with scale scores of symptoms, anxiety, depression and sleep quality.ResultsCompared with HCs, IBS-D patients showed increased fALFF in the left cuneus, left superior and middle occipital gyri, and left pericalcarine cortex; decreased fALFF in the right insula and bilateral precuneus/posterior cingulate cortex; and increased zReHo in the left thalamus/insula and sensorimotor regions. FC was altered, characterized by reduced insula-prefrontal connectivity, decreased sensorimotor-SMA connectivity, and enhanced thalamus/insula-hippocampal connectivity. DTI revealed lower FA in the left corticospinal tract, left cingulum bundle and right uncinate fasciculus with widespread MD and RD increases. Correlation analyses showed that fALFF in precuneus/posterior cingulate cortex was positively correlated with SAS (r = 0.422, q = 0.045), zReHo in thalamus/insula with SDS (r = 0.489, q = 0.013), and MD with PSQI (r = 0.360, q = 0.047).ConclusionIBS-D is associated with multi-network, multi-level alterations involving the default mode network, thalamus-insula circuit, and sensorimotor network, with exploratory associations observed between select imaging dimensions and particular affective symptom dimensions. These findings provide subtype-focused, hypothesis-generating neuroimaging evidence for brain alterations in IBS-D.

Posttraumatic stress and depression among traumatized, treatment-seeking, Arabic-speaking refugees and non-refugees in Southwest Asia and North Africa (SWANA)

BackgroundCountries in Southwest Asia and North Africa (SWANA) have been particularly affected by numerous conflicts for the last few decades, a development which has had an influence on the mental health of both refugee and non-refugee populations. Simultaneously, there is comparably less provision of and access to mental health services in SWANA. Given these circumstances, the present study implements a cross-country comparative design to investigate the mental health of treatment-seeking individuals in the region and compare the mental health of refugees and non-refugees.MethodsTreatment-seeking refugees and non-refugees originating from and residing in the SWANA region were examined regarding post-traumatic stress disorder (PTSD; PCL-5) and depression (PHQ-9). Participants were recruited from an open-label dissemination study between 2021 and 2025 (N = 19,198; n(refugees) = 888; n(non-refugees) = 18,310). A refugee (n = 888) and a non-refugee subsample (n = 888) were created using propensity score matching for comparability (i.e., using gender, education status, employment status, type of residence, family status, and country of origin and residence as matching variables). Prevalence rates were compared between groups, and moderation models were computed to assess the differential impact of protective and risk factors on the mental health of the two groups.ResultsSignificant differences were found for PTSD (refugees: 84%; non-refugees: 78%) and depression prevalence (refugees: 77%; non-refugees: 70%), with further above-chance differences regarding the number of traumatic event types (refugees: 7.35; non-refugees: 4.77). Linear regression models indicated that social support and trauma load were associated with symptom load across groups and outcomes but did not differentiate between groups. Having previously been in psychological or psychiatric treatment was associated with higher depression symptom load for refugees only.ConclusionThe PTSD prevalence rate was higher for treatment-seeking refugees across the SWANA region, emphasizing the heightened vulnerability of this population even relative to a traumatized, treatment-seeking non-refugee comparison group. Moreover, an association of previous treatment was found for refugees, potentially indicating a threshold mechanism by which refugees with comparably higher depressive symptom load are more likely to receive treatment. The results underline the need for increased access to mental health care services for both groups across SWANA.

Discordance between clinician-rated and patient-reported outcomes during 48-week community care for schizophrenia: longitudinal patterns and associations with insight

BackgroundRecovery in schizophrenia is multidimensional, but whether clinician-rated and patient-reported outcomes (PROs) improve concordantly during community care is unclear. We examined their longitudinal discordance and its association with insight and treatment attitudes.MethodsIn this secondary analysis of a 48-week, multicity, naturalistic cohort, 306 community-dwelling adults with schizophrenia in Guangdong, China, were assessed at baseline and weeks 12, 24, 36, and 48 using the Positive and Negative Syndrome Scale (PANSS), Personal and Social Performance Scale (PSP), Schizophrenia Quality of Life Scale (SQLS), and Insight and Treatment Attitudes Questionnaire (ITAQ). Changes in PANSS, PSP, and SQLS were standardized using baseline standard deviation (SD) units, with positive values indicating improvement. Study-defined symptom-PRO and function-PRO recovery gaps were estimated using mixed-effects models adjusted for age, sex, city, and baseline treatment pathway. A joint week-48 bootstrap test was conducted, and ITAQ was decomposed into within-person and between-person components.ResultsAt week 48, adjusted improvements were 0.30 SD for PANSS (95% CI, 0.23 to 0.37), 0.20 SD for PSP (95% CI, 0.12 to 0.28), and 0.46 SD for SQLS (95% CI, 0.37 to 0.54). The symptom-PRO gap was -0.16 SD (95% CI, -0.27 to -0.05), and the function-PRO gap was -0.26 SD (95% CI, -0.38 to -0.14), indicating greater patient-reported improvement than clinician-rated improvement (joint Q = 24.58, df = 2, p < 0.001). The gaps were evident from week 12; the symptom-PRO result was sensitive to city composition. At the 0.5-SD threshold, patient-reported-only improvement was more frequent than clinician-rated-only improvement for symptom-PRO (20.7% vs. 11.3%) and function-PRO (22.4% vs. 12.3%) comparisons. For each 1-SD occasion-specific increase in ITAQ, the gaps shifted 0.08 and 0.06 SD toward the clinician-rated direction, but the joint test was inconclusive (p = 0.064).ConclusionDuring routine community care, patient-reported quality of life improved more than clinician-rated psychopathology and social functioning, with the discrepancy larger and more robust for functioning. Parallel monitoring may better characterize symptom, function, and quality-of-life trajectories, while the role of time-varying insight and treatment attitudes warrants further study.

STAT+: Across the U.S., homegrown experiments aim to save kids from their phones

MILWAUKEE — Kat Zilka sat on the floor of her living room, beside a glowing Christmas tree and a pile of essays, and felt like weeping. It was late in 2022, and she had asked her 12th grade digital journalism students to reflect on their relationships to devices. 

“The things they were writing were deeply disturbing,” she said. 

Teenagers quietly enduring online abuse, using their phones all night without their parents’ knowledge, or trapped in a cycle of deleting and redownloading social media. Their words made real what Zilka had been observing for years — how the light in students’ eyes was dimmer, especially since Covid — and revealed the astonishing magnitude of the problem.

Continue to STAT+ to read the full story…