The Download: introducing the Nature issue

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Introducing: the Nature issue

When we talk about “nature,” we usually mean something untouched by humans. But little of that world exists today. 

From microplastics in rainforest wildlife to artificial light in the Arctic Ocean, human influence now reaches every corner of Earth. In this context, what even is nature? And should we employ technology to try to make the world more “natural”?  

In our new Nature issue, MIT Technology Review grapples with these questions. We investigate birds that can’t sing, wolves that aren’t wolves, and grass that isn’t grass. We look for the meaning of life under Arctic ice, within ourselves, and in the far future on a distant world, courtesy of new fiction by the renowned author Jeff VanderMeer. 

Together, these stories examine how technology has altered our planet—and how it might be used to repair it. Subscribe now to read the full print issue.

What’s next for large language models?

After ChatGPT launched in late 2022, the OpenAI chatbot became an everyday everything app for hundreds of millions of people. It led to LLMs being heralded as the new future. The entire tech industry was consumed by the inferno, with companies racing to spin up rival products.

But what’s the next big thing after LLMs? More LLMs—but better. Let’s call them LLMs+. Find out how they’re set to become cheaper, more efficient, and more powerful.

—Will Douglas Heaven

LLMs+ is on our list of the 10 Things That Matter in AI Right Now, MIT Technology Review’s guide to what’s really worth your attention in the busy, buzzy world of AI. We’ll be unpacking one item from the list each day here in The Download, so stay tuned.

Will fusion power get cheap? Don’t count on it.

Fusion power could provide a steady, zero-emissions source of electricity in the future—if companies can get plants built and running. But a new study published in Nature Energy suggests that even if that future arrives, it might not come cheap.

The research team aimed to improve predictions of fusion’s future price by estimating the technology’s experience rate—the percentage by which its cost declines every time capacity doubles. Their findings offer new clues on the technology’s path to deployment. Read the full story.

—Casey Crownhart

This story is from The Spark, our weekly climate newsletter. Sign up to receive it in your inbox every Wednesday.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Trump signaled he’s open to reversing the Anthropic ban
What that really means in practice remains to be seen. (Reuters $)
+ Anthropic says there’s no “kill switch” for its AI. (Axios)
+ “Humans in the loop” in AI warfare is an illusion. (MIT Technology Review)

2 SpaceX plans to manufacture its own GPUs
To support the company’s growing AI ambitions. (Reuters $)
+ Musk is shifting SpaceX’s focus from Mars to AI ahead of its IPO. (NYT $)
+ SpaceX and Tesla may be on a collision course. (FT $)

3 Chinese tech giant Tencent has unveiled its first flagship AI model
A former OpenAI researcher is at the helm. (SCMP)
+ Chinese open models are spreading fast. (MIT Technology Review)

4 High earners are racing ahead on AI, deepening workplace divides
The division in adoption risks widening inequality. (FT $)
+ Startups are bragging they spend more on AI than staff. (404 Media)

5 Thousands of Samsung workers are demanding a new share of AI profits
Chip-division employees want 15% of the operating profit. (Bloomberg $)
+ Here’s why opinion on AI is so divided. (MIT Technology Review)

6 AI is helping mediocre Korean hackers steal millions
They’re vibe coding their malware. (Wired $)
+ AI is making online crimes easier. (MIT Technology Review)

7 Kalshi suspended three political candidates for betting on their own races
Including a Democrat and a Republican running for Congress. (CNN)
+ And an independent candidate who said he did it to make a point. (Gizmodo)
+ Lawmakers argue that prediction markets are a loophole for gambling. (NPR)

8 A ping-pong robot is beating elite human players for the first time
The Sony AI system was trained with reinforcement learning. (New Scientist)
+ Just days earlier, a humanoid smashed the human half-marathon record. (AP)

9 Crypto scammers are luring ships into the Strait of Hormuz
By falsely promising safe passage. (Ars Technica)

10 ‘Age tech’ could help us grow old comfortably at home
Apps, wearables, and remote monitoring could fill caregiving gaps. (NYT $)

 

Quote of the day

“It’s a hallucinogenic business plan.”

—Ross Gerber, the chief executive of Gerber Kawasaki, an investment firm that owns SpaceX shares, tells the New York Times that he’s unimpressed by Musk’s changing goals for the aerospace company. 

One More Thing

Photos of victims are displayed under white crosses at a memorial for the August 2023 wildfire victims

AP PHOTO/LINDSEY WASSON


This grim but revolutionary DNA technology is changing how we respond to mass disasters

After hundreds went missing in Maui’s deadly fires, victims were identified with rapid DNA analysis—an increasingly vital tool for putting names to the dead in mass-casualty events.

The technology helped identify victims within just a few hours and bring families some closure more quickly than ever before. But it also previews a dark future marked by the rising frequency of catastrophic events.

Find out how this forensic breakthrough is preparing us for a more volatile world.


—Erika Hayasaki

We can still have nice things

A place for comfort, fun and distraction to brighten up your day. (Got any ideas? Drop me a line.)

+ This fascinating dive into botanical history reveals the origins of the first true plants.
+ Here’s how to use Google’s reference desk to find what ordinary search engines miss.
+ Watch duct tape get deconstructed to reveal the physics behind its legendary stickiness.
+ When Radiohead covers Joy Division, the result is a beautiful intersection of two legendary musical eras.

Transcutaneous auricular vagus nerve stimulation for paroxysmal sympathetic hyperactivity syndrome after intracerebral hemorrhage: a hypothesis-generating case report

ObjectiveTo observe the clinical effect of transcutaneous auricular vagus nerve stimulation (taVNS) in drug-refractory paroxysmal sympathetic hyperactivity (PSH).MethodsThis case report describes the clinical course of a 63-year-old male with PSH following intracerebral hemorrhage. PSH episodes were characterized by tachypnea, tachycardia, hypertension, and increased muscle tone. After 2 weeks of combination pharmacotherapy (propranolol, baclofen, gabapentin), blood pressure, heart rate, and muscle tone improved, but tachypnea remained inadequately controlled. Although sedative agents alleviated tachypnea, they led to decreased consciousness level and could not be continued. Subsequently, taVNS was added to the ongoing pharmacotherapy.ResultsAfter 4 weeks of taVNS treatment, PSH episode frequency and tachypnea improved. Baclofen and gabapentin were discontinued, propranolol dosage was reduced, and the patient’s consciousness level showed improvement. After another 4 weeks of continued treatment, only mild tachypnea occurred occasionally under strong stimulation, without other sympathetic symptoms. Consciousness level further improved.ConclusionThis case suggests that taVNS may be a safe adjunctive intervention option for drug-refractory PSH. The symptom relief and consciousness improvement observed during treatment may be related to the application of taVNS.

Functional methods for evaluating the efficacy of retinal optogenetic therapy for vision restoration

Optogenetic therapy is a promising strategy for vision restoration. Functional assays have an important role in assessing the modulation of neural activity in response to light stimulation. Each functional assay needs to be carefully considered and evaluated for the preclinical development of optogenetic approaches to work toward meaningful vision restoration. Each strategy contributes to understanding the efficacy of vision restoration and the physiology of retinal optogenetic therapy. At a molecular level, bioluminescence resonance energy-transfer based and G protein coupling assays can be used. Calcium imaging provides measurements with useful spatial and temporal resolution using fluorescent calcium indicators at the cellular level. Electrophysiological tests can include ex vivo recordings by patch-clamping at single-cell resolution, multielectrode array recordings at the network level, and in vivo recordings at the lateral geniculate nucleus and cortical levels. Behavioural tests such as light avoidance, optomotor response and visual discrimination assess functional restoration in vivo. In this review, each functional assay is discussed in the context of retinal optogenetic therapy with notable examples that have demonstrated vision restoration. The advantages, disadvantages, and limitations of each assay are critically compared to highlight their relative scientific value and applicability across different stages of development. This provides insight into how these methods can be integrated within a translational framework, from molecular validation to behavioural outcomes, to better inform the design of preclinical studies. As clinical trials in optogenetic therapy continue to expand, improved alignment between preclinical functional assays and clinically meaningful endpoints will be essential to maximise translational success.

Speech recognition performance with dual-microphone audio processors in mandarin-speaking cochlear implant users

BackgroundCochlear implant (CI) audio processor upgrades have demonstrated speech recognition benefits in non-tonal language populations, but high-level evidence for native Mandarin-speaking CI users (a tonal language with unique signal processing requirements) remains critically limited. This study aimed to assess the speech perception performance of the SONNET 2 and RONDO 3 dual-microphone audio processors in native Mandarin-speaking CI users.MethodsThis prospective single-subject repeated-measures study enrolled 51 native Mandarin-speaking CI users. Speech recognition performance was tested across five processor configurations: the legacy baseline processor, SONNET 2 (S2) in omnidirectional (S2.OMNI) and adaptive intelligence (S2.Adaptive) modes, and RONDO 3 (R3) in omnidirectional (R3.OMNI) and adaptive intelligence (R3.Adaptive) modes. Outcome measures included monosyllabic words, disyllabic words, and sentence recognition in quiet, and sentence recognition in co-located speech-shaped noise (S0N0 paradigm). The pre-specified primary endpoint was sentence recognition in noise for S2.OMNI vs. the legacy processor; confirmatory linear mixed-effects models (LMMs) and subgroup analyses were exclusively performed for the primary endpoint, with pairwise comparisons for all secondary exploratory endpoints.ResultsIn quiet, all four upgraded configurations yielded significantly higher monosyllabic word recognition scores vs. the legacy baseline (all p < 0.05, FDR-adjusted); all configurations except R3. Adaptive showed significant improvements in disyllabic word recognition (all p < 0.05, FDR-adjusted). In the S0N0 noise condition, S2.OMNI and R3.OMNI significantly enhanced sentence recognition vs. the legacy processor (p < 0.001 and p = 0.011, respectively, FDR-adjusted), while no significant benefit was detected for either adaptive mode after FDR correction. LMM analysis confirmed that upgrading to the S2.OMNI configuration was an independent positive predictor of noise sentence recognition (F = 9.885, p = 0.003), with consistent significant benefits across pediatric/adult and unilateral/bilateral users in pre-specified subgroup analyses.ConclusionThis study provides confirmatory evidence that upgrading to the S2.OMNI configuration significantly improves sentence recognition in noise in native Mandarin-speaking CI users, with consistent benefits across key clinical subgroups. Exploratory analyses show that the S2 and R3 processors also deliver significant improvements in word recognition in quiet, These results fill a critical evidence gap for tonal language CI populations and may help guide clinical device selection.

Cortical activity during cognitive and walking tasks in individuals with chronic nonspecific low back pain: a functional near-infrared spectroscopy study

IntroductionPrevious research demonstrates that individuals with chronic nonspecific low back pain (CNSLBP) exhibit changes of gait patterns. However, the neural mechanisms responsible for these adverse events remain unelucidated. In this study, we used functional near-infrared spectroscopy (fNIRS) to investigate cortical activities during cognitive and walking tasks to provide evidence of the central mechanisms responsible for changes of gait patterns in individuals with CNSLBP.MethodsIn this cross-sectional study, we evaluated 18 individuals with CNSLBP (the CNSLBP group) and 18 healthy controls (the HC group) under three specific conditions: Task 1 (a single walking task), Task 2 (a single cognitive task) and Task 3 (a cognitive-walking dual task). Cortical activities were measured using fNIRS, including the bilateral premotor cortex and supplementary motor area (PMC/SMA), primary motor cortex (M1), somatosensory association cortex (SAC), and primary somatosensory cortex (S1). Gait parameters, including step duration, step length, stride length, velocity, cadence, swing power, and cycle, were measured using a three-dimensional gait analysis system.ResultsIn Task 1, the CNSLBP group exhibited a significantly lower velocity (p = 0.029) and higher activation in the left SAC (p = 0.001) and right S1 (p = 0.018) than that of the HC group. In Task 2, the CNSLBP group exhibited higher activation in the left SAC (p = 0.028), right SAC (p = 0.033), and left S1 (p = 0.032). In Task 3, the CNSLBP group exhibited significantly lower step length (p = 0.031), stride length (p = 0.041), velocity (p = 0.016), and swing power (p = 0.047). Correlation analysis in Task 1 revealed stronger associations between parameters in the CNSLBP group.ConclusionOur findings suggest that individuals with CNSLBP exhibit distinct patterns of cortical activities and gait performance. The SAC and S1 were involved in walking, and central sensitization was observed in individuals with CNSLBP in daily cognitive and walking tasks. These findings could contribute to the recovery and rehabilitation of CNSLBP.

Intracerebroventricular diphtheria toxin causes off-target toxicity in CD11b-DTR and wild-type mice, revealing limitations of DTR-based depletion studies

Diphtheria toxin receptor (DTR)–based depletion models are widely used to study microglial and macrophage function, yet the extent to which diphtheria toxin (DT) produces off-target effects remains incompletely defined. Here, we examined tolerability, behavioural outcomes, and cellular responses following intracerebroventricular (i.c.v.) DT administration in wild-type (WT) and CD11b-DTR mice. Mice received bilateral i.c.v. infusions of DT or vehicle over a 10-day period and were assessed for survival, motor and cognitive behaviour, myeloid cell changes, and neuropathology. Unexpectedly, DT induced dose-dependent mortality in WT mice, demonstrating that toxicity can occur independently of DTR expression. CD11b-DTR mice exhibited greater susceptibility, with reduced survival and the emergence of illness at lower DT doses. Behavioural testing revealed significant dose-dependent impairments in rotarod performance and Y-maze spontaneous alternation in both genotypes, while open-field mobility was largely preserved among animals. Region-specific analysis of myeloid cells in CD11b-DTR mice showed robust depletion in the midbrain at higher DT doses, whereas hippocampal cell numbers remained unchanged with marked morphological signs of activation. These findings indicate that DT-mediated myeloid cell responses vary across brain regions, potentially reflecting differential toxin exposure following ventricular delivery. Consistent with this, focal abnormalities in the brain—including ventriculitis, meningoencephalitis and spongiotic changes—were observed in a subset of clinically affected DT-treated animals, whereas peripheral organs were largely unremarkable and haematological changes were infrequent. Together, these data demonstrate that i.c.v. DT administration can induce mortality, behavioural dysfunction, and focal CNS pathology in both WT and CD11b-DTR mice, with transgene expression amplifying susceptibility. Our findings highlight the need for careful dose optimisation, appropriate DT-treated controls, and cautious interpretation of behavioural phenotypes when employing this model.

Psychological function in the context of protracted stress during war: a multi-sample, multivariate longitudinal study

Continuous traumatic stress has wide-ranging implications for important life outcomes across multiple domains. We present the design protocol from the first waves of one of the most comprehensive studies of the impact of one pervasive continuous traumatic stress context—war—on individuals. In this ongoing project we have been collecting quantitative and qualitative data on psychological function, risk, and resilience at different levels of influence and at various junctures during the ongoing 2023–2025 Hamas-Israel war from three samples (total N = 16,330). We present this large-scale, multi-sample, multivariate, mixed-method, longitudinal study, and showcase select, preliminary findings at different levels of analysis and in different samples (e.g., concerning war exposure, trust in institutions, and well-being). We document the design, scope, and future trajectory of the project, encouraging interdisciplinary, cross-border collaborations among researchers across diverse fields. This is important not only for understanding responses to the current conflict, but also for understanding risk and resilience in other conflict-affected regions and among populations facing continuous traumatic stress more broadly.

Association between the geriatric nutritional risk index and postoperative delirium: a meta-analysis

BackgroundMalnutrition has been suggested as an important contributor to postoperative delirium (POD). The geriatric nutritional risk index (GNRI), a simple indicator based on serum albumin and body weight, has been increasingly evaluated in surgical patients. This meta-analysis aimed to clarify the association between GNRI and the risk of POD.MethodsPubMed, Embase, and Web of Science were searched for observational studies evaluating the association between categorized GNRI and POD. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using random-effects models accounting for heterogeneity.ResultsTwelve cohort studies involving 12,332 surgical patients were included. Overall, low GNRI was associated with a significantly increased risk of POD (RR = 1.62, 95% CI: 1.34–1.96; I² = 27%). Subgroup analyses showed a stronger association in studies with mean patient age > 74 years compared to ≤ 74 years (p for subgroup difference = 0.02) and in those using GNRI cutoffs < 98 compared to ≥ 98 (p = 0.04). The association was weaker in studies using multivariate analyses compared with univariate analyses (p = 0.01). Meta-regression indicated that GNRI cutoff values significantly influenced the pooled effect (p = 0.04). The funnel plot showed mild asymmetry, whereas Egger’s test was not significant (p = 0.11), and trim-and-fill analysis produced a similar pooled estimate (RR = 1.54, 95% CI: 1.26–1.87).ConclusionsLow GNRI is associated with an increased risk of POD in surgical patients, suggesting that preoperative nutritional assessment may help identify individuals at higher risk for this complication.Systematic Review RegistrationThe study protocol was registered prospectively in the PROSPERO database (registration number: CRD420261335609).

Auditory processing and communication in autism: exploring verbal abilities and vocal affective cues

This study examined the role of auditory processing in autism spectrum disorder, focusing on its association with verbal and non-verbal vocal communication skills in children and adolescents. A total of 97 English-speaking autistic participants (ages 7.9–17.4 years, mean = 12.3) and 44 neurotypical peers (ages 8.4-16.8, mean= 12.3) completed assessments of auditory processing and communication skills. We analyzed the relationships between scores on the SCAN-3 Tests for Auditory Processing Disorders time-compressed sentences, auditory figure-ground (+ 8dB), gap detection, and competing words-free recall subtests, the Clinical Evaluation of Language Fundamentals-Fifth Edition (CELF-5) expressive and receptive language indices, the Goldman-Fristoe Test of Articulation-3rd Edition (GFTA-3) Sounds-In-Words subtest, and the Diagnostic Analysis of Nonverbal Accuracy-2nd Edition (DANVA-2) paralanguage subtests. Measures of auditory processing were associated with both verbal and non-verbal communication skills in the autistic participants. Specifically, we found that SCAN-3 time-compressed sentence and gap detection scores were associated with expressive and receptive language skills, receptive vocabulary scores, and ability to recognize vocal emotional cues. Gap detection abilities additionally correlated positively with expressive and receptive language skills, while auditory figure-ground task performance was related to articulation. In conclusion, this study suggests specific aspects of auditory processing may be important for development of specific aspects of auditory communication skills in children on the spectrum. Specifically, spectral aspects of auditory processing abilities were associated with articulation accuracy whereas temporal components of auditory processing may impact broader verbal and nonverbal communication skills. Further research is needed to better understand the underlying mechanisms of these associations and potential directions of causality to inform development of interventions that target auditory processing and auditory communication skills in ASD.

Appearance-related attentional bias is associated with dysmorphic appearance concern in individuals with jaw deformity: an eye-tracking study

IntroductionAppearance-related attentional bias has been body dysmorphic disorder (BDD) and in individuals with elevated concern; however, it remains unclear whether similar attentional are observed in individuals with objectively verifiable jaw deformities. Appearance-related attentional bias has been observed across clinical populations with elevated appearance concern, highlighting its relevance as a general perceptual-cognitive mechanism associated with appearance monitoring.MethodsSixty patients with jaw deformities and 40 age-matched completed the Body Image Concern Inventory (BICI), a validated measure of dysmorphic appearance concern, and underwent eye-while viewing photographs of self and others’ faces. Gaze duration analyzed across six regions (forehead, eyes, nose, mouth, jaw, and Associations between gaze patterns and BICI scores were examined.ResultsPatients exhibited significantly higher BICI scores than controls. both self- and other-face viewing, patients showed prolonged gaze region. Furthermore, exploratory correlation analyses showed that gaze positively associated with BICI scores within the patient group and other’s faces.DiscussionIndividuals with jaw deformities exhibit elevated dysmorphic appearance concern and increased attention to perceptually salient features. These findings characterize appearance-related attentional individuals with jaw deformities and provide insight into perceptual-processes associated with dysmorphic appearance concern.