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Sleep Quality and Biomarkers in Adolescent Girls With Anorexia Nervosa

Conditions: Anorexia Nervosa Interventions: Procedure: Longitudinal Fasting Blood Sampling for Biomarker Assessment; Other: Multimodal Psychiatric Treatment Program; Device: Home Polysomnography - NOX A1 Sponsors: University of Split, School of Medicine; University Hospital of Split Not yet recruiting

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Correction: Barriers and Facilitators in the Implementation of the Systematic Medical Appraisal, Referral, and Treatment (SMART) Mental Health Digital Intervention in Rural India: Mixed Methods Process Evaluation Study

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Prevalence and Predictors of Self-Reported Adverse Experiences in Digital Meditation Training: 2 Randomized Controlled Trials

Background: Digital meditation-based interventions (MBIs) reach vast global audiences with millions of active users, yet concerns persist about the frequency and nature of adverse experiences (ie, AExs) occurring during meditation training. Some researchers have argued that AExs are substantially underdetected…

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Between Help and Harm: An Evaluation Study of Mental Health Crisis Handling by Large Language Models

Background: The use of large language models (LLMs)–powered chatbots has reshaped how people seek information and advice, including for emotional and mental health support. While LLMs can offer scalable support, their ability to safely detect and respond to acute mental…

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Examining the Social and Mental Health Benefits of Virtual and In-Person Physical Activity Intervention Among Postsecondary Students: Quasi-Experimental Study

Background: Physical activity (PA) is a promising prevention approach for supporting mental health and enhancing social inclusion among postsecondary students. However, it is unclear whether similar outcomes are realized when PA programming is delivered in-person versus virtually. Objective: Using data…

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Tracking the longitudinal course of physiologic and mental health functioning among individuals in substance use disorder treatment

IntroductionMental health monitoring is crucial to long-term recovery in substance use disorder (SUD) treatment; however, little is known about how changes in physiological indicators align with changes in self-reported mental health over time.MethodsWe examined longitudinal associations of resting heart rate…

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Association between plasma proBDNF levels and cognitive impairment in patients with alcohol dependence: a case–control and longitudinal study

BackgroundAlcohol dependence is frequently accompanied by cognitive impairment. Brain-derived neurotrophic factor (BDNF) signaling plays a critical role in synaptic plasticity, while the precursor form, proBDNF, has been increasingly implicated in neurodegenerative and psychiatric disorders. However, the association between plasma proBDNF…

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Are Republicans turning against medications for treating opioid addiction?

Federal actions and proposals have reignited debate over methadone and buprenorphine, worrying addiction experts and patient groups.

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The Intersectionality of OCD and the Shame Surrounding Sexuality 

By Mike Vatter Obsessive-Compulsive Disorder (OCD) is often misunderstood as a condition involving excessive cleanliness, organization, or ritualistic behavior. In reality, OCD is a complex mental health disorder characterized by... Read more » The post The Intersectionality of OCD and…

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Evaluation of the Relationship Between Medication, Eye Movements, and Autonomic Nervous System (ANS) Functions in Children and Adolescents With ADHD

Conditions: ADHD - Attention Deficit Disorder With Hyperactivity Interventions: Drug: metylphenidate Sponsors: Umeå University; Region Västerbotten; Stockholm University Recruiting

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Clinical Trial Evaluating the Effects of Ganaxolone in Children With Autism

Conditions: Autism in Children; Autistic Disorder in Children and Adolescents; Autism Spectrum Disorder Interventions: Drug: Ganaxolone (Ztalmy); Drug: Placebo Sponsors: Stanford University; SPARK NS Not yet recruiting

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Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture

Conditions: Psychopathy Interventions: Device: continuous theta burst stimulation (cTBS); Device: Intermittent theta burst stimulation (iTBS); Device: Sham Sponsors: University of Colorado, Denver; National Institute of Mental Health (NIMH) Not yet recruiting

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The SAVOR Study: Appetite and Physiological Responses

Conditions: Anorexia of Aging; Malnutrition or Risk of Malnutrition Interventions: Other: Shredded Chicken Congee Sponsors: Singapore Institute of Food and Biotechnology Innovation Not yet recruiting

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Testing STAR and TextSTAR: A Randomized Controlled Trial

Conditions: Sexual Violence; Posttraumatic Stress Disorder (PTSD); Opioid Misuse Interventions: Behavioral: Skills Training in Active Recovery (STAR) Video; Behavioral: Text Skills Training in Active Recovery (TextSTAR) program Sponsors: University of Wisconsin, Madison; National Institute on Drug Abuse (NIDA) Enrolling by…

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SleepPathfinder: A Socratic Questioning and Self-Decision–Based Chatbot to Support User Engagement in Digital CBT-I: Usability and Feasibility Study

Background: Chronic insomnia is a highly prevalent sleep disorder that adversely affects quality of life and mental health. Cognitive behavioral therapy for insomnia (CBT-I) is internationally recommended as the first-line treatment, and digital CBT-I (dCBT-I) has been developed to improve…

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New national action plan targets gaps at the intersection of mental health and criminal justice.

FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based roadmap to address systemic gaps in…

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Fronto-Parietal Transcranial Alternating Current Stimulation for ADHD in Children and Adolescents

Conditions: Attention-Deficit/Hyperactivity Disorder Interventions: Device: Active transcranial alternating current stimulation; Device: Sham transcranial alternating current stimulation Sponsors: Central South University Recruiting

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Awakening from the Trance

This blog was originally posted by the TLC Foundation for BFRBs Trichotillomania touches on all levels of human experience, from the neurological to the spiritual. It represents the interactions of... Read more » The post Awakening from the Trance appeared…

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A Comparative Study of Driving Performance Among Adolescents With Autism Spectrum Disorder and Neurotypical Adolescents

Conditions: Autism Spectrum Disorders Interventions: Other: Assessment of executive functions and attention; Other: Evaluation on a driving simulator; Other: Evaluation on-road Sponsors: Hopital La Musse; French Road Safety Delegation Not yet recruiting

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CanSOLVE 2.0 Theme 3.1 Mind the Gap – Dialectical Behavioural Therapy (DBT) Skills Training Program Pilot

Conditions: Mental Health; Mental Health Care; Hemodialysis; DIALYSIS SYMPTOMS AND ANXIETY; Health Related Quality of Life Interventions: Behavioral: Dialectical Behavioural Therapy Skills Training Sponsors: University of Manitoba; Canadian Institutes of Health Research (CIHR) Recruiting

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