BackgroundPhysical health is the basic indicator to evaluate the health of drug addicts after the process of drug rehabilitation. In order to better improve the deficiency degree of physical health of drug addicts, it is necessary to carry out a systematic review.ObjectiveTo explore the effects of exercise intervention on the physical health of individuals undergoing compulsory drug rehabilitation using Meta-Analysis, aiming to provide evidence-based support for improving their physical health.MethodsRandomized controlled trials (RCTs) published between 2019 and December 2024, examining the impact of exercise intervention on the physical health of compulsory detoxification individuals, were retrieved from databases including Web of Science, PubMed, Cochrane Library, Medline, China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP Chinese Journal Database. The quality of included studies was assessed using the Cochrane risk-of-bias assessment tool. RevMan 5.4 software was employed for heterogeneity testing, effect size synthesis (using mean difference [MD] and 95% confidence interval [CI]), and generation of forest plots, funnel plots, and quality assessment diagrams. Subgroup analyses were performed to evaluate sensitivity and heterogeneity of the included studies.ResultsExercise intervention effectively improved the physical health of compulsory drug rehabilitation individuals, particularly in physical fitness indicators: sit-and-reach test [MD = 3.92, 95%CI = (3.23, 4.62), P<0.001], single-leg standing with eyes closed [MD = 7.03, 95%CI = (6.05, 8.02), P<0.001], grip strength [MD = 1.23, 95%CI=(0.06, 2.39), P = 0.04], and choice reaction time [MD=-0.03, 95%CI=(-0.05, -0.01), P = 0.002]. Improvements in physical function were also observed; however, the increase in vital capacity [MD = 86.81, 95%CI=(-1.56, 175.17), P = 0.05] did not reach statistical significance.ConclusionThis meta-analysis provides evidence that exercise intervention significantly improves specific physical health deficits—namely flexibility (sit-and-reach), balance (single-leg stance), muscular strength (grip strength), cardiopulmonary function (vital capacity), and sensorimotor coordination (choice reaction time)—in individuals undergoing compulsory rehabilitation. It is recommended to adopt a combination of aerobic and traditional fitness exercises, with at least 3 sessions per week, each lasting no less than 40 minutes, and a duration of over 12 weeks, providing scientific evidence for drug rehabilitation practices. These indicators were selected because they directly reflect the multisystem damage (muscular, neural, and cardiorespiratory) caused by chronic substance use. However, this study acknowledges the limitation that psychological and neurocognitive outcomes (e.g., cravings, mood, executive function), which are crucial in addiction treatment, were not included in the eligibility criteria and systematic analysis. The follow-up research will combine physical and psychological indicators to conduct a comprehensive evaluation of the intervention effect of exercise on drug rehabilitation.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD420251029820.
STAT+: OxyContin maker Purdue Pharma set to dissolve after judge approves its criminal sentence
NEWARK, N.J. — OxyContin maker Purdue Pharma is set to be dissolved and replaced by a company focused on the public good by the week’s end, as a massive legal settlement resolving thousands of lawsuits takes effect.
A federal judge on Tuesday delivered a criminal sentence to the company to resolve a Department of Justice probe — a last necessary step to clear the way for the settlement.
U.S. District Judge Madeline Cox Arleo made her decision after listening to hours of impact statements from people who lost loved ones or struggled with addiction themselves and requested she reject the negotiated sentence. While she didn’t go that far, she said she sympathized with people who bore the brunt of an epidemic linked to more than 900,000 deaths in the U.S. since 1999.
The Impact of Digital Detox Training on Screen Use, Sleep Quality, and Healthy Lifestyle Behaviors in Adolescents
Conditions: Digital Screen Addiction and Sleep Quality in Adolescents
Interventions: Behavioral: Digital Detox Intervention
Sponsors: Şırnak Üniversitesi
Completed
Interventions: Behavioral: Digital Detox Intervention
Sponsors: Şırnak Üniversitesi
Completed
Scoping review of therapeutic approaches among individuals with secondary exercise addiction
Secondary exercise addiction shows high comorbidity with eating and body image disorders. Despite its substantial impact on physical and mental health and daily functioning, evidence on effective therapeutic interventions remains limited. The aim of this scoping review was to identify and describe therapeutic interventions applied to adult individuals with secondary exercise addiction. This review followed the PRISMA Sc-R guidelines and covered the years 2002–2024. Ultimately, five studies were included (four randomized controlled trials and one quasi-experimental study). Three studies applied psychotherapeutic interventions based on cognitive-behavioral models (Cognitive Behavioral Therapy, Lifestyle, Exercise, Attitudes, and Relationships Program, Physical Exercise and Dietary Therapy), while two integrated physical or nutritional components. A secondary analysis published in 2024 based on the LEAP trial dataset was identified but not treated as an independent study to avoid duplication. EBSCOhost, Web of Science, PubMed, and Google Scholar were searched from January to May 2025 using terms related to exercise addiction, exercise abuse, psychotherapy, intervention, and treatment. English-language studies were eligible if they described an intervention with at least one treated group with pre- and post-test measures; the participants of the study were adult patients suffering from eating disorders and exercise addiction (the therapy programs involved one inpatient and four outpatient treatments) and therapeutic intervention was carried out with outcomes based on exercise addiction level data. Four out of five included studies reported improvements in variables related to compulsivity, although these did not always imply a reduction in the amount of exercise, indicating that qualitative changes may be more relevant. Longer interventions showed more consistent effects, but even brief treatments generated positive changes in non-clinical populations. The examination of the research revealed a gap in studies addressing interventions for those with secondary exercise addiction, especially highlighting the need for randomized controlled trials (RCTs) with proper randomization methods.
Trump administration warns against using federal dollars on fentanyl test strips
The Trump administration is doubling down on its opposition to harm reduction services for people who use illicit drugs.
In an open letter on April 24, the federal agency overseeing addiction and mental health policy warned its grantees against using federal funds to buy harm reduction supplies including sterile syringes and pipes, or to distribute test strips for common drug supply adulterants like fentanyl, xylazine, and medetomidine.
The Download: DeepSeek’s latest AI breakthrough, and the race to build world models
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.
Three reasons why DeepSeek’s new model matters
On Friday, Chinese AI firm DeepSeek released a preview of V4, its long-awaited new flagship model. Notably, the model can process much longer prompts than its last generation, thanks to a new design that handles large amounts of text more efficiently.
While the model remains open source, its performance matches leading closed-source rivals from Anthropic, OpenAI, and Google. It is also DeepSeek’s first release optimized Huawei’s Ascend chips—a key test of China’s dependence on Nvidia.
Here are three ways V4 could shake up AI.
—Caiwei Chen
The rise of world models
AI systems have already gained impressive mastery over the digital world, but the physical world remains humanity’s domain. As it turns out, building an AI that composes novels or code apps is far easier than developing one to fold laundry or navigate city streets. To bridge this gap, many researchers believe you need something called a world model.
Proponents like Stanford professor Fei-Fei Li and AMI Labs founder Yann LeCun argue these models can overcome the well-known limitations of LLMs—and realize AI’s promise for robotics. Find out why they’ve brought world models to the forefront of the field.
—Grace Huckins
World models are on our list of the 10 Things That Matter in AI Right Now, our essential guide to what’s really worth your attention in the field.
Subscribers can watch an exclusive roundtable unveiling the technologies and trends on the list, with analysis from MIT Technology Review’s AI reporter Grace Huckins and executive editors Amy Nordrum and Niall Firth.
The must-reads
I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.
1 China has blocked Meta’s $2 billion acquisition of AI startup Manus
Regulators cited national security grounds. (WSJ $)
+ Beijing called the deal a “conspiratorial” attempt to hollow out its tech base. (FT $)
+ The country is tightening its grip on AI firms that try to leave. (TechCrunch)
+ The decision escalates China’s AI rivalry with the US. (Bloomberg $)
+ But there will be no winners in their competition. (MIT Technology Review)
2 Google is investing up to $40 billion in Anthropic
In a deal valuing the AI firm at $350 billion. (CNBC)
+ The funding will support the firm’s growing computing needs. (TechCrunch)
+ Anthropic and OpenAI are fighting for compute capacity. (Axios)
3 President Trump just fired the entire National Science Board
The NSF has played a crucial role in developing technology. (The Verge)
+ The move heightens fears over political interference in US science. (Nature)
4 Conspiracy theories about the Washington shooting are proliferating online
Over 300,000 posts appeared on X using the keyword “staged.” (NYT $)
+ The theories are also swirling on Bluesky and Instagram. (Wired)
5 The AI compute crunch is starting to hit the broader economy.
It’s affecting jobs, gadgets, and electricity prices. (404 Media)
+ The AI compute explosion is the tech story of our time. (MIT Technology Review)
6 Elon Musk says a new banking tool brings X close to a “super app”
He’s pledged to launch the tool this month. (Bloomberg)
7 AI optimism is surging across Asia while US sentiment cools
The divide could shape where adoption happens fastest. (Rest of World)
8 Apple is tying its new CEO’s ascent to its first foldable iPhone
It wants to build the buzz around John Ternus. (Gizmodo)
9 Twelve firms are developing the Golden Dome’s space-based interceptors
They’ve won contracts worth up to $3.2 billion. (Ars Technica)
10 NASA has shared promising results from Artemis II
The spacecraft and rocket fared well. (Engadget)
Quote of the day
“Getting out the truth and establishing facts and reliable information takes time. But our audiences really don’t have that kind of patience.”
—Amanda Crawford, associate professor at the University of Connecticut, tells the NYT why conspiracy theories are gaining traction online.
One More Thing
MIRIAM MARTINCIC
Welcome to Kenya’s Great Carbon Valley: a bold new gamble to fight climate change
Kenya’s Great Rift Valley is home to five geothermal power stations, which harness clouds of steam to generate about a quarter of the country’s electricity. But some of the energy escapes into the atmosphere, while even more remains underground for lack of demand. That’s what brought Octavia Carbon here.
Last year, the startup began harnessing some of that excess energy to remove CO2 from the air. The company says the method is efficient, affordable, and—crucially—scalable. But the project also faces fierce opposition.
Read the full story on the future of Kenya’s “Great Carbon Valley.”
—Diana Kruzman
We can still have nice things
A place for comfort, fun and distraction to brighten up your day. (Got any ideas? Drop me a line.)
+ Fred Again’s Tiny Desk Concert is a masterclass in intimate performance.
+ Here’s a delightful look at how we’re all linked through geography and shared heritage.
+ Take a short, peaceful break to watch Tokyo’s cherry blossoms from a bird’s eye view.
+ There’s something oddly satisfying about watching an industrial shredder turn everyday items into confetti.
How adolescent cannabis use reshapes the developing brain — a systematic review
Background and hypothesisCannabis use initiation during adolescence has increased globally, raising concerns about neurodevelopmental consequences during this critical period when the brain undergoes extensive remodeling in cannabinoid receptor-rich regions.Study designThis systematic review examines neurodevelopmental consequences of adolescent cannabis use, focusing on structural brain changes, cognitive impacts, addiction vulnerability, and long-term outcomes. We searched PubMed, EMBASE, PsycINFO, and Web of Science (2000-2025) for studies examining cannabis effects in adolescent populations. Following PRISMA guidelines, two reviewers screened 3,421 records and assessed 156 full-text articles, including studies with neuroimaging, cognitive assessments, or longitudinal follow-up.Study resultsThirty-six studies involving 8,432 participants met criteria: 23 longitudinal cohorts (62.2%), 8 cross-sectional (22.2%), 4 RCTs (11.1%), and 1 case-control study (2.8%). Neuroimaging revealed dose-dependent alterations including reduced prefrontal cortical and hippocampal/amygdala volumes, accelerated cortical thinning in longitudinal studies, and impaired white matter connectivity correlating with initiation age. Cognitive findings were mixed — some showed persistent deficits after prolonged abstinence in adolescent-onset users, others found no effects after controlling for confounders. Epidemiological studies consistently showed elevated addiction risk (ORs 3.9–7.2) in adolescents versus adults. Long-term associations included educational difficulties, mental health problems, and functional impairment, though causal relationships remained unclear.ConclusionsAdolescent cannabis use associates with structural brain changes, elevated addiction risk, and variable cognitive effects, suggesting greater vulnerability versus adult-onset use. However, methodological limitations including confounders, heterogeneous definitions, and observational designs limit causal inference. Findings support age-specific prevention and specialized interventions while highlighting needs for rigorous longitudinal research establishing causality.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifierCRD420251165329.
Adapted RPM-08 for Substance Use Disorder in Pakistan
Conditions: Substance Use Disorder (SUD); Drug Abuse; Relapse
Interventions: Behavioral: Adapted Relapse Prevention Module (RPM-08); Other: Treatment as Usual (TAU)
Sponsors: Universiti Sains Malaysia
Completed
Interventions: Behavioral: Adapted Relapse Prevention Module (RPM-08); Other: Treatment as Usual (TAU)
Sponsors: Universiti Sains Malaysia
Completed
A longitudinal inquiry into the vicious cycle of social media addiction and self-injury: the moderating role of resilience
BackgroundThe reciprocal relationship between social networking addiction (SNA) and non-suicidal self-injury (NSSI) represents a critical, yet poorly understood, feedback loop in adolescent psychopathology. This study aimed to longitudinally test a “vicious cycle” model, examining the bidirectional effects between SNA and NSSI, and to investigate psychological resilience as a potential protective factor that could disrupt this harmful dynamic.MethodsA three-wave longitudinal study was conducted with a large cohort of 2,628 Chinese high school students (mean age = 16.1 years; 53.1% female) over a 12-month period. Participants completed measures of SNA, NSSI frequency, and psychological resilience at each wave. A cross-lagged panel model (CLPM) was used to examine the reciprocal, prospective relationships between SNA and NSSI. A multi-group CLPM was then employed to test the moderating role of resilience.ResultsThe CLPM revealed significant, positive, and reciprocal cross-lagged effects. SNA at T1 and T2 prospectively predicted increases in NSSI at T2 and T3, respectively (βs = .19 and.17). Conversely, NSSI at T1 and T2 prospectively predicted increases in SNA at T2 and T3 (βs = .14 and.12), providing robust evidence for a vicious cycle. Furthermore, resilience significantly moderated the pathway from SNA to NSSI. For adolescents with low resilience, the effect was strong and significant (β = .25), whereas for those with high resilience, the effect was rendered non-significant (β = .07).ConclusionsSocial networking addiction and non-suicidal self-injury are not merely comorbid but are locked in a mutually reinforcing developmental spiral over time. However, this dangerous cycle is not deterministic. Psychological resilience acts as a powerful protective buffer, effectively uncoupling the link from addictive social media use to self-harm. These findings underscore the urgent need for integrated, dual-focus interventions that address both online and offline maladaptive behaviors, while championing resilience-building as a primary strategy for prevention.
Psychedelics get a boost from the White House
President Trump recently signed an executive order which aims to increase access to psychedelic drug treatments. He was joined at the signing by podcaster Joe Rogan, who said he’ ha’d messaged the president about research on the psychedelic ibogaine.
In this week’s STATus Report, host Alex Hogan chats with STAT Washington correspondent Daniel Payne about what the executive order does and doesn’t do. Hogan also looks at why ibogaine, and psychedelic drugs more broadly, are increasingly being taken seriously for stubbornly hard-to-treat conditions like addiction, depression, and PTSD.