Digital Mental Health Research Priorities, Revisited for the AI and Large Language Model Era

Digital mental health has become an established part of mental health care, but the rapid arrival of large language models and other artificial intelligence tools has refocused attention on the evidence needed to guide the field. This editorial updates the research priorities articulated by JMIR Mental Health in 2023, while reaffirming their emphasis on equity, replicability, privacy, efficacy, and engagement. What has changed is not the importance of these priorities, but the urgency with which they must now be applied. As digital tools become more clinically consequential, research must move beyond demonstrating that a technology is feasible, usable, or novel. The field needs studies that clarify how these tools work, for whom they are beneficial, under what conditions they may cause harm, and how they can be responsibly integrated into care. We call for research that is transparent about the technologies being studied, grounded in meaningful clinical questions, attentive to safety and accountability, and designed to produce knowledge that remains useful as specific products and models change. The promise of digital mental health will depend less on the sophistication of emerging tools than on the quality of the evidence used to shape their role in care.
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Maintaining Emotional Boundaries as a Parent

Parents often emphasize to children the importance of respecting others’ boundaries — don’t tickle another kid if they say they don’t like it, for example. Don’t kiss someone unless they welcome it. But within the family, we can fail to notice our own difficulty setting and respecting boundaries with our children, especially emotional boundaries.

What are emotional boundaries

Emotional boundaries refer to an individual’s sense of autonomy and ability to control how they think, feel, and engage with others. Those boundaries are crossed either when you try to control someone else’s thoughts or feelings or they try to control yours.   

Difficulty setting your own and respecting others’ emotional boundaries often comes from a place of care and concern. Parents are usually concerned that their child is not going to make safe choices or are trying to protect their child from distressing emotions. But the intrusion can have a negative impact on children’s emotional development as well as parents’ mental health, especially when it’s done repeatedly. Everyone has boundaries, even parents, and it’s important for kids to learn that.  

How parents overstep their child’s emotional boundaries

Parents can inadvertently encroach on their child’s right to their own thoughts and feelings through:

  • Over-involvement in children’s academic and social life: Your child has a whole life outside the home, and it can be anxiety-provoking to trust them to manage their homework, advocate for themselves with teachers, and navigate conflicts with peers. It can alleviate your anxiety to get involved, but that can feel highly intrusive to your child. For example, if your kid feels snubbed by a friend, you might feel the urge to contact that friend’s parent to try to smooth things over. However, over-involvement in these tasks can prevent your kid from developing the skills they need to manage challenging situations successfully and can impact their confidence in their ability to cope independently.
  • Overconcern to protect your child’s safety: Fears that something negative will happen to your child are understandable, but aggressive monitoring can backfire. This can include strict control over the ingredients in your teen’s food, the information they consume online, or what activities they do. This may temporarily alleviate anxiety about the child’s health and safety but it can lead to resentment and rebellion. 
  • Ignoring or rejecting children’s requests for privacy: It is normal for children and adolescents to want more privacy as they mature, from showering alone to keeping a private diary.Unless your child engages in an activity that suggests they are being unsafe, it is important to trust your child and let them decide what to share with you.
  • Sharing private information without the child’s permission: Parents telling anecdotes about their children, much to their kids’ embarrassment, is hardly new. However, that sharing now includes photographs and videos posted on social media that is broadcast far beyond close friends.It is important to include your child in decisions about what information is shared with others (excluding, of course, medical professionals). When in doubt, consider what information you would feel comfortable with them sharing about you.
  • Telling children what is or isn’t acceptable to value, think, or feel: Many parents, in an effort to help their child feel better, say things like, “Don’t worry about that” or “You can’t think that way.” These seemingly innocuous phrases can come across as attempts to control how the child feels. We can forget that kids are real people just like adults. And if they’re mad or upset about something, they want to be able to feel those feelings, not be told that that their feelings are wrong.

How parents fail to set their own emotional boundaries

Letting kids change your own values, thoughts, and feelings can also be unhealthy. Here are some common ways in which parents fail to set their own boundaries:

  • Allowing your child’s thoughts and feelings to influence your own too much:  Your child may act like it will be the end of the world if they don’t get into the right college. If their anxiety becomes your anxiety, then it’s going to be very hard for you to encourage your kid to have fun on the weekend or to go to bed with work left undone. What they need you to do is validate their feelings but challenge those worry thoughts and help them to relax.
  • Implying that your child is responsible for how you feel:  As a parent, your child’s well-being is your priority, and your emotional state is affected by your child’s behavior. But phrases like, “You are making me crazy” or “I cannot cope with one more word from you” unintentionally suggest that the child has control over your feelings. It’s not healthy for children to feel that they are responsible for your well-being.
  • Depending on your child for emotional support: If you’re a parent under stress and you’re not getting support elsewhere, it makes sense that you’re going to vent to a child. It’s not necessarily meant to burden a kid with financial stressors or relationship drama, and the child might be a sympathetic ear. But it blurs the boundaries between the parent role and the kid role, and that often causes difficulties for the kid in accepting parental authority in other domains. If they see themselves as equals in terms of emotional support, then they might think, why can you tell me what to do?
  • Sharing age-inappropriate information: Many children want to be treated as older than they are (at least in certain ways). So they might requestinformation about finances, romantic relationships, or family stressors that are inappropriate for their age. Although it can be tempting to share, it is not helpful long-term. It may alleviate the child’s current anxiety (and stop the nagging), but it will impair their ability to respect boundaries as well as interfere with them just being a kid.
  • Difficulty saying no: If you’re exhausted, the last thing you want is an argument. One way to avoid an argument is to say yes to your kid’s requests to buy a toy, stay up 15 more minutes, or have a different dinner. If you have boundaries around what you will spend, how much sleep you need, or what you will cook, you are still a good parent. Sticking to your limits teaches your child to accept other people’s boundaries without whining or threats. 
  • Allowing your child to treat you unkindly: Many parents allow their children to treat them in ways they would never tolerate from another person. This includes calling the parent mean or profane names, hitting them, or disregarding their needs (for money, sleep, leisure time, etc.).  Allowing this kind of behavior prevents the child from learning how to respect boundaries and tolerate the emotions they experience when they face them.

Factors that contribute to boundary concerns

There are specific circumstances that can make it difficult for a parent to know where the appropriate boundaries are. They include a child’s late development, psychiatric challenges, and history of unsafe choices. For example, a child may have delays in language, executive functioning, or social or emotional skills. These things can make it challenging to determine how involved you need to be in your child’s daily life and how much independence they can handle.

  • Poor risk assessment and impulsivity: Many disorders can impact children’s ability to think clearly, regulate emotionally, and act safely. For example, a teen experiencing a manic episode may overestimate their abilities, underestimate risk, and act impulsively. Or a child with ADHD might hard to control on crowded city streets or in restaurants, so you avoid taking them out or letting them do activities on their own with friends.  
  • Lack of confidence: Anxious children may underestimate their abilities and request continued support past when they are capable of independence. For example, a socially anxious child may ask their parent to order for them at a restaurant or keep track of their homework assignments.  When a parent accommodates these requests, it confirms their belief that they still need help.
  • Executive functioning deficits: Children who struggle with executive functioning may need more scaffolding to complete daily self-care tasks than other kids their age. This can look like parents providing frequent reminders of assignments, events, or even hygiene tasks — as well as cleaning their room for them long past when an child with ADHD should be doing it themselves. Consider how you can scaffold the skills (packing their bookbag!) without doing tasks for them, and gradually remove the supports over time.
  • History of not successfully navigating tasks: A child’s history of poorly handling a responsibility (safe use of technology, completion of homework, brushing their teeth) often reduces parents’ confidence in the child’s abilities and increases their inclination to step in. Although extra supervision and support may be needed initially, it is important to reassess your child’s abilities over time as they can learn and grow if you let them!

How to get better at boundaries

Once you have recognized the challenges in respecting your child’s boundaries and protecting your own, the next step is to figure out what those boundaries are.

  • Identify your boundaries: What things are most important to support your child’s growing independence and sense of autonomy? What boundaries do you need to set to protect your own mental health? Consider what level of involvement you want to have in their academics, friendships, emotion regulation, and appearance and what you want to disclose to them about your own relationship, emotions, or work.  
  • Practice setting these boundaries: It is much easier to set a boundary when you are not forced to make the choice with a child’s puppy dog eyes looking at you. Rehearsing how you will say no, decline to share certain information, or respond to an anxiety-provoking situation can prepare you to respond more effectively and in line with your values in a moment of conflict.
  • Share your reasons for boundaries: Children can be quick to interpret lack of boundaries as “more caring,” but being consistent in language around why boundaries are being set can help prevent this. When setting a boundary, it is helpful to couch it in care. For example, “I care about you enjoying your childhood, so I do not feel comfortable sharing with you about our family’s finances.”

When kids want more independence than you are sure they are ready to handle, identifying steps toward their goal can be effective. Giving them opportunities to show maturity, with success at one step leading to more responsibility, can help you trust your child with greater independence. What can your kids show you that will help you feel confident in their ability to manage their emotions themselves or make well thought-out decisions?

Kids also need to recognize that they sometimes overestimate their own abilities, that there are times they have not assessed risk accurately and still need their parents. It is important to teach your child that you should be alerted if they are experiencing something that is unsafe or concerning (such as a friend talking about suicide or sharing an inappropriate photo). Discussions with your kid can sort out how to work toward new milestones and help everybody feel confident that they have the skills to do it.

Modeling a healthy respect for boundaries will set your child up to establish their own and respect others’ boundaries throughout their life.

Frequently Asked Questions

What are emotional boundaries between parents and children?

Emotional boundaries are the limits that protect each person’s right to their own thoughts, feelings, values, and decisions. In families, healthy boundaries allow children to develop independence while helping parents avoid taking responsibility for emotions or choices that belong to their child.

Why are emotional boundaries important in parenting?

Healthy emotional boundaries support children’s confidence, autonomy, and ability to solve problems on their own. They also protect parents’ well-being by preventing them from becoming overly responsible for their child’s feelings, worries, or decisions.

What are signs a parent is overstepping a child’s emotional boundaries?

Common signs include getting overly involved in a child’s friendships or school life, refusing age-appropriate privacy, sharing personal information without permission, or telling a child what they should think or feel. While these behaviors often come from a place of love and concern, they can undermine a child’s confidence and independence.

How can parents determine appropriate emotional boundaries?

Parents can start by considering where their child is developmentally and what level of support versus independence is appropriate. A good guideline is to provide enough structure to keep children safe while gradually giving them more responsibility and privacy as they demonstrate readiness.

The post Maintaining Emotional Boundaries as a Parent appeared first on Child Mind Institute.

How diet therapy affects obesity-associated depressive symptoms: from mechanism to therapeutics

Obesity stands as a formidable 21st-century public health crisis, with its capacity to aggravate depressive symptoms gaining increasing clinical attention. Traditional treatment models often treat these two conditions separately. However, recent research evidence suggests a complex network linking obesity and depressive symptoms across metabolism, behavior, and mental health, with dietary patterns proposed as a key upstream modulator of both metabolic and psychological pathways. The specific mechanisms by which diet influences obesity and depressive symptoms remain unclear. Therefore, this narrative review focuses on analyzing molecular connections between diet, obesity, and depressive symptoms, including adipose tissue inflammation, the gut-brain axis, the hypothalamus-pituitary–adrenal axis, insulin and brain-derived neurotrophic factor levels, and neuroplasticity. We discuss the possible pathways and effects of different diet therapies in regulating metabolism and simultaneously impacting mental health, including calorie restriction diet, intermittent fasting, ketogenic diet, low glycemic index diet, plant-based diet, Mediterranean diet, Dietary Approaches to Stop Hypertension, among others. This review aims to provide a scientific basis for precision nutrition and personalized, sustainable diet therapies in clinical practice, promoting awareness and improving treatment strategies for depressive symptoms in obese patients.

Prevalence of pharmacologically treated attention deficit hyperactivity disorder in children, adolescents, and adults: systematic review and meta-analysis

IntroductionAttention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental paediatric disorders and persists into adulthood, although it is frequently underdiagnosed and underrecognized in adult populations. In this context, the prevalence of pharmacologically treated individuals diagnosed with ADHD represents an important quality indicator for ADHD management.AimTo estimate the pooled prevalence of pharmacologically treated individuals with ADHD in different age groups in Europe and worldwide.MethodsA comprehensive search of PubMed/MEDLINE was conducted to identify relevant articles published up to October 4, 2024. The present systematic review and meta-analysis examined ADHD prevalence using clinically confirmed diagnoses and treatment data from official records. The exclusion criteria included studies that lacked clinical confirmation of ADHD and/or relied exclusively on parental reports for diagnostic or medication information. The prevalence of pharmacologically treated individuals with ADHD was calculated as a percentage, with a 95% confidence interval (CI). A meta-analysis was performed in R using a random-effects model. Heterogeneity was calculated using I². Prediction intervals were additionally computed to reflect the expected range of prevalence in future studies. Risk of bias was assessed for all included studies using a standardized, previously published methodology. The study was prospectively registered in PROSPERO (CRD42020200220) and adhered to the PRISMA guidelines for systematic review and meta-analysis (2020).ResultsThe systematic review identified 13 studies (12 studies included in the meta-analysis) with substantial variation in age-specific reporting. The pooled prevalence of pharmacologically treated ADHD was 73.4% (95% CI: 63.4–81.5), with extremely high between-study heterogeneity and wide 95% prediction interval (29.6%–94.5%), reflecting substantial variation across settings. The pooled prevalence estimate should be interpreted with caution due to substantial between-study heterogeneity and is not intended for direct clinical inference. Geographic analyses revealed no significant variation across countries. Sex-stratified analyses showed no significant difference between males and females, although point estimates were slightly higher in males.ConclusionThe prevalence of pharmacological treatment among individuals with ADHD appears to vary across age groups and settings Overall, findings indicate substantial variation in pharmacological treatment of ADHD by age, with consistently high heterogeneity limiting the precision of pooled estimates.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42020200220.

Efficacy of digital interventions in social anxiety disorder: a systematic review and Bayesian network meta-analysis

BackgroundSocial anxiety disorder (SAD) is characterized by a significant and persistent fear of social or performance situations. The prevalence of SAD has gradually increased recently, and the unique advantages of digital interventions (DIs) have gained traction in psychiatric disorders. However, there is currently no comprehensive review comparing the effectiveness of diverse DIs for SAD.MethodsRandomized controlled trials (RCTs) evaluating DIs for patients with SAD were identified by searching the PubMed, Cochrane Library, and Embase databases from January 1, 1995, to March 31, 2025. The study protocol for this network meta-analysis was registered in PROSPERO. Data were analyzed via Bayesian framework network meta-analysis.ResultsForty-two RCTs were included. The results showed that DIs exerted better efficacy than non-digital interventions and wait-list controls (WLC). Different forms of internet-based cognitive behavioral therapy (ICBT) demonstrated robust effects across all four outcomes. Internet-based cognitive therapy (ICT) yielded favorable effects in reducing social anxiety and depressive symptoms. VR showed relatively large effect sizes for improving quality of life.ConclusionDIs can be recommended as adjunctive or combined treatments for SAD. Different forms of ICBT show consistent efficacy and can serve as the first-line option among digital interventions. We recommend promoting the application of DIs to expand treatment coverage for SAD and overcome the limitations of traditional psychotherapy.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD420251077835.

The ECHO study: compassion-focused therapy for young voice hearers and their caregivers. A pilot study

BackgroundVoice hearing can occur in healthy people without a trigger, be caused by a traumatic event, or occur as part of a psychiatric disorder. There are still many gaps in our understanding of voice hearing, and research in this field can be challenging, maybe because it is associated with shame and stigma. Those who experience distress by voice hearing could benefit from a treatment, aimed directly at that. The ECHO manualized treatment is based on the principles of compassion-focused therapy (CFT).MethodsTreatment will take place on several different psychiatric hospitals in the Region of Southern Denmark. Treatment consists of a 10-session, manualized CFT for voice hearing. Caregivers participate in half of the sessions, and a recording of the voice content is made, which the caregivers are encouraged to listen to. The study is designed as a prospective single-arm pre–post intervention study using a mirror-image approach, in which participants serve as their own controls over time. The intervention group consists of (N = 60) voice-hearing adolescents aged 13–18 years. Additionally, a clinical comparison group (who also receive the intervention) of (N = 20) individuals aged 18–20 years with first-episode schizophrenia and voice hearing is included for descriptive and exploratory analyses. Data are collected 3 months prior to CFT treatment, immediately before the start of treatment, immediately after treatment is completed, and at 1 month follow-up. Data will be centered around social cognition, perceived social safeness, social connectedness, general well being, auditory hallucinations and compassion.DiscussionThe ECHO study addresses the wellbeing and thriving of an overlooked group of young people. The results of this study will provide information about who the voice hearers are, what challenges they face, and how they perceive them. The results will also provide information about the feasibility and efficacy of the treatment manual and, thus, its potential further implementability. Caregivers participate in half of the sessions, to facilitate a common language about mental states and voice hearing. To support their understanding, a recording of the voice content is made and the caregivers are encouraged to listen to it. We suggest that when caregivers understand the young voice hearers’ experiences, they can adjust their expectations and approach accordingly. We also suggest that by sharing the voice content, the young voice hearer will feel less isolated.Study protocol registrationhttps://clinicaltrials.gov/study/NCT07314515, identifier NCT07314515.

New York boys club has a time-tested recipe to protect members’ mental health

NEW YORK — A couple of years ago, a reporter approached the Boys’ Club of New York looking to interview some of its middle-schoolers for a story about the mental health crisis in boys. 

It’s easy to see why. Many of the about 2,500 boys who participate in the 150-year-old organization’s after-school and weekend activities come from disadvantaged socioeconomic backgrounds, often living in single-parent households or facing the threat of immigration enforcement. With limited access to academic and developmental support, the risk factors are plentiful. 

Read the rest…

A novel mutation in SETD1A is associated with early-onset epilepsy—a rare case report

SET Domain Containing 1A (SETD1A) is a histone H3K4 methyltransferase implicated in neurodevelopmental disorders. Pathogenic variants in this gene are associated with schizophrenia, intellectual disability, and epilepsy. Here, whole-exome sequencing and Sanger sequencing were performed on a 4-year-old Chinese girl with early-onset epilepsy and her unaffected parents. A novel de novo heterozygous variant in SETD1A (NM_014712.3: c.1067C > T/p.Ser356Phe) was identified in a patient presenting with focal-to-bilateral tonic–clonic seizures, beginning at 3 months of age. Neuroimaging revealed a normal brain MRI, and comprehensive neuropsychological assessment indicated preserved cognitive function. The variant was absent in 200 local controls and classified as likely pathogenic per ACMG criteria. This study may expand the mutation and phenotypic spectrum of SETD1A-related disorders, establishing the relationship between SETD1A variants and isolated early-onset epilepsy without accompanying severe neurodevelopmental deficits, highlighting the value of genetic testing in infants with unexplained epilepsy.

Local field potentials for target localization in centromedian deep brain stimulation for epilepsy

ObjectiveTo evaluate whether local field potential (LFP) spectral profiles can serve as a candidate “spectral fingerprint” for physiological confirmation of centromedian-parafascicular (CM–Pf) targeting during thalamic deep brain stimulation (DBS) for drug resistant epilepsy (DRE).MethodsThis is a retrospective study of 10 patients (20 leads) who underwent CM-DBS implantation for DRE at a single tertiary center. Postoperative CT and preoperative MRI were co-registered, normalized to the Montreal Neurological Institute (MNI) space, and reconstructed using Lead-DBS software to anatomically localize contacts. BrainSense™ Survey recordings were obtained at least 3 weeks post-implant during routine programming. LFP frequency content was analyzed, and prominent peaks were identified and classified into canonical frequency bands (theta, alpha, beta). These spectral profiles were then mapped to MRI-based anatomical localizations, and statistical tests were applied to assess associations between peak patterns, contact localizations and thalamic subregions.ResultsContacts were distributed as follows: 50 in the CM, 16 in the Parafascicular (Pf), 15 in the Centrolateral, 8 in the Mediodorsal, and 7 in the Ventrolateral (VL) nuclei. Of the 10 representative spectral localizations confined to the CM/CM-Pf region, 8 (80%) displayed a distinct dual-peak spectral profile with peaks in the theta/low alpha (5.5–9 Hz) and high beta (20–30 Hz) bands (mean frequencies: 7.63 Hz and 21.02 Hz, Fisher’s exact test, p < 0.001). Single-peak profiles showed no significant association with specific nuclei (p = 0.871). Contacts overlapping other thalamic nuclei more frequently exhibited narrow 10–15 Hz peaks (p = 0.005) or triple-peak profiles (p = 0.02), suggesting mixed structural contributions.ConclusionA dual- band candidate spectral pattern consisting of theta/low alpha and high beta peaks was associated with the CM-Pf region in this cohort. This finding provides early evidence supporting the feasibility of incorporating passive LFP recordings as a physiologic marker of target engagement. Future work to prospectively compare bipolar survey-based localization with monopolar recording strategies could enable development of a state-based, physiologically informed spectral atlas to refine CM-Pf targeting in thalamic neuromodulation for DRE.

Autistic- and attention-deficit/hyperactivity disorder-like traits: differential associations with burnout, depression and anxiety, and empathy among Japanese junior residents

IntroductionBurnout, depression, and anxiety are major concerns among physicians because they affect individual well-being, patient care, and healthcare systems. Neurodevelopmental traits, including autistic-like traits (ALTs) and attention-deficit/hyperactivity disorder (ADHD)-like traits (ADHLTs), may increase vulnerability to psychological distress. However, little is known about how these traits relate to burnout, depression and anxiety, and empathy among junior residents.MethodsIn this cross-sectional study, 148 junior residents from two teaching hospitals in Japan completed validated measures of ALTs (21-item Japanese version of the Autism-Spectrum Quotient), ADHLTs (Adult ADHD Self-Report Scale Screener), burnout (Maslach Burnout Inventory), depression and anxiety (Hospital Anxiety and Depression Scale), physician–patient empathy (Jefferson Scale of Physician Empathy), and psychological flexibility and inflexibility processes (Valuing Questionnaire, Cognitive Fusion Questionnaire-7, and Work-related Acceptance and Action Questionnaire). Associations were examined using multivariable logistic and linear regression analyses. Exploratory statistical mediation analyses using structural equation modeling examined indirect associations through psychological flexibility and inflexibility processes.ResultsThe prevalence of ALTs and ADHLTs was 23.6% for each trait. ALTs were associated with lower personal accomplishment, a burnout dimension; higher depression and anxiety; and lower physician–patient empathy. ADHLTs were associated with greater emotional exhaustion, another burnout dimension. In exploratory statistical mediation analyses, progress toward values, a core process of psychological flexibility, showed a significant indirect association between ALTs and personal accomplishment, and the direct association was attenuated and no longer statistically significant after including the process variables. Significant indirect associations through progress toward values were also observed for the associations of ALT with depression and anxiety and empathy. Cognitive fusion, a core process of psychological inflexibility, showed a significant indirect association between ADHLTs and emotional exhaustion. Overall, neurodevelopmental traits were associated with distinct patterns of psychological functioning, suggesting variability in both vulnerability and adaptive processes.DiscussionNeurodevelopmental traits such as ALTs and ADHLTs were significantly associated with burnout dimensions, depression and anxiety, and physician–patient empathy among junior residents. Psychological flexibility and inflexibility processes, particularly progress toward values and cognitive fusion, may be relevant to these associations. Process-based support strategies may warrant further investigation for residents with elevated neurodevelopmental traits.Clinical trial registrationhttps://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R00005, identifier UMIN000046897.