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Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)

Conditions: Borderline Personality Disorder (BPD); Treatment-Resistant Major Depressive Disorder; Treatment-resistant Bipolar Depression; Major Depressive Disorder (MDD); Bipolar Disorder (BD); Bipolar Disorder I or II; Suicidal Ideation

Interventions: Drug: Ketamine Hydrochloride; Drug: Midazolam Hydrochloride; Behavioral: Dialectical Behavioral Therapy (DBT)

Sponsors: Joshua Rosenblat

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A PIVOT towards single-cell functional genetic screening in plants

Nature Biotechnology, Published online: 05 May 2026; doi:10.1038/s41587-026-03141-0

We developed PIVOT, a single-cell screening platform for functional characterization of plant genes. PIVOT enables delivery of gene libraries to tobacco leaves with single multiplicity of infection and magnetic sorting of single plant cells by phenotype. We use PIVOT to recover regulators of cytokinin signaling from an Arabidopsis open reading frame library.

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Autonomous pathology research using agentic AI shows potential in oncology

Nature Medicine, Published online: 05 May 2026; doi:10.1038/s41591-026-04403-9

The agentic artificial intelligence tool SPARK is able to reproduce pathology-based reasoning and produce biological hypotheses and relevant diagnostic, prognostic and predictive cellular parameters. The output of SPARK has the potential to advance the understanding of tumor biology and enable the development of diagnostic, prognostic and predictive tools for pathology and oncology.