Opinion: STAT+: The medical AI revolution requires rethinking health care’s architecture

There is a kind of labor at the center of medicine that rarely appears in a chart. It does not sit in the problem list or the billing code. It unfolds in conversation, often quietly, as a patient tries to give shape to something real but not yet defined. They reach for words that are approximate — tired, off, not quite right. The words are not false; they are insufficient. What is being described is not a diagnosis but an experience, and experience resists compression.

In clinical practice, this work lives in a specific place: the history of present illness, or HPI. The HPI reconstructs what has happened to a person over time — how symptoms emerged, evolved, interacted with the physical world, and were perceived. It precedes examination. It precedes testing. It is where medicine begins.

The physician’s task in the HPI is not transcription but interpretation. We ask what was happening when the symptom appeared, whether it arose with exertion or at rest, whether recovery changed, whether confidence shifted before function did. We test meanings against timelines and refine language against physiology, gradually aligning what was said with what can be understood clinically, because the lived details of onset, progression, and functional change materially alter the pre-test probability of disease. A laboratory value or imaging finding does not carry the same meaning in every patient; its significance is conditioned by the story that precedes it.

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Testing Conversational Agents as a Digital Companion

Conditions: Autism

Interventions: Behavioral: self-directed goal coaching

Sponsors: Friendi.fi Corporation; National Institute of Mental Health (NIMH); University of Louisville; Indiana University; Ball State University; University of Nebraska

Recruiting

An inducible base editing platform for cancer functional genomics in vivo

Nature Biotechnology, Published online: 15 April 2026; doi:10.1038/s41587-026-03079-3

We developed a functional genomics platform using a small-molecule-controllable base editor that enables gene editing with reduced cellular toxicity and minimal transcriptional perturbation. The resulting high efficiency of the method potentiates in vivo inducible genetic screening, allowing systematic identification of critical residues in cancer therapeutic targets.

Baseline Mismatch Negativity Amplitude Predicts Direction and Magnitude of Ketamine Effect in Healthy Volunteers — A “Disordinal” Effect

Mismatch negativity (MMN) is a component of the auditory event-related potential (ERP) that is elicited during a passive oddball paradigm where task-irrelevant infrequent deviants are presented in a stream of more frequent standard stimuli. MMN is believed to index a pre-attentive stage of auditory information processing closely linked to N-methyl-D-aspartate receptors (NMDAR) function. Ketamine is thought to act primarily as an NMDAR antagonist, has been used in clinical trials to model the symptoms of schizophrenia and is increasingly used in the clinic to treat depression.

Can psychiatric genetics advance without incorporating a lifecourse perspective?

Psychiatric disorders unfold over the lifecourse, yet genomic studies of these conditions overwhelmingly rely on phenotypes collected at a single time point, often in adulthood. Genome-wide association studies (GWAS) of psychiatric conditions may therefore miss genetic variants with time-varied relevance to etiology, prevention and treatment, such as those that influence trajectories of symptoms and behaviors, age-at-onset, course of treatment response, and co-evolution of comorbidities. With recent advances in longitudinal biobanks and analytic tools, we posit that incorporating a lifecourse perspective in psychiatric genetics will enable critically relevant insights into each of these areas of investigation.

[Comment] Psychonauts: reimagining recovery in forensic psychiatry

Inside a locked forensic ward at the University Psychiatric Hospital Vrapče—Croatia’s oldest and largest psychiatric institution—patients began building a world of their own: one puppet, one frame at a time. Psychonauts, an 8-minute stop-motion film co-created by forensic psychiatric in-patients, started as an unassuming art therapy exercise but gradually evolved into a powerful act of collective authorship. Originating behind secure doors, Psychonauts is now on its own journey, reaching spotlights, being celebrated at prestigious international festivals (including Special Mention at Annecy, 2025, and Best Short at Guanajuato, 2025), currently even in consideration for an Oscar.

[Comment] Youth mental health in central Asia: research needs

Little research has been published on mental health difficulties in young people (aged 10–24 years) living in central Asia,1 a region comprising Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. As researchers and representatives from academic, non-governmental, governmental, and UN organisations working in Kyrgyzstan and Uzbekistan and beyond, we are noting an increasing number of young people reporting emotional and behavioural symptoms in central Asia in published articles2 and from our own observations.