Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03109-0
AI targets lipid nanoparticles to specific tissues while avoiding off-target delivery to the liver.
Pool-packaged AAV libraries exhibit extensive length-dependent and homology-dependent chimerism
Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03097-1
Pooled production of recombinant AAV vectors leads to frequent genetic recombination.
Australia legislates against genetic discrimination in life insurance
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04372-z
Genomic screening is increasing rapidly, but insurance protections globally are outdated. Australia’s new law offers the clearest model yet for safeguarding public trust while supporting population genomics.
A reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04267-z
A reasonably likely surrogate endpoint for metabolic dysfunction–associated steatohepatitis
Clinical trials for continuously monitored and updated AI systems
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04368-9
As artificial intelligence becomes embedded in clinical workflows, trials must accommodate ongoing monitoring and updates.
AI framework for multidisease detection via retinal imaging
Nature Medicine, Published online: 28 April 2026; doi:10.1038/s41591-026-04359-w
Reti-Pioneer, a retinal imaging artificial intelligence framework, identified diverse systemic diseases and demonstrated feasibility in a primary care silent trial, offering a pathway toward scalable clinical evaluation.
Human Ventral Tegmental Local Field Potentials in Treatment-Resistant Depression and Obsessive-Compulsive Disorder
The ventral tegmental area (VTA) is a key node within the limbic circuitry. Through dense dopaminergic, glutamatergic, and GABAergic projections, the VTA forms reciprocal loops with prefrontal and limbic cortices that are consistently implicated in major depressive disorder (MDD) and obsessive–compulsive disorder (OCD) (1,2). Decades of animal research have established the VTA as a central hub for motivational drive and reward prediction error signaling (3,4). Despite its presumed critical role in mental disorders, direct electrophysiological recordings from the human VTA have so far remained absent.
The Biological Psychiatry Family of Journals Is Rewarding Its Reviewers
The Biological Psychiatry family of Journals (Biological Psychiatry (BPS); Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (BP:CNNI); Biological Psychiatry: Global Open Science (BP:GOS) is pleased to announce a new program that, beginning this year, will both recognize and reward our most productive reviewers. This reward system was developed in collaboration with the leaders of the Society of Biological Psychiatry (SOBP) and is underwritten by the Society. We are initiating this program with no changes to publication fees for authors who publish in our Journals and without increasing the cost of SOBP membership.
The prefrontal cortex controls memory organization in the hippocampus
Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02231-1
Related memories are sometimes encoded in overlapping neurons. The authors show that the prefrontal cortex controls this type of memory organization in the hippocampus through direct projections to the medial entorhinal cortex.
Genoarchitecture and input–output organization of the mouse basal ganglia and thalamic parafascicular nucleus
Nature Neuroscience, Published online: 28 April 2026; doi:10.1038/s41593-026-02253-9
The authors investigate the transcriptomic and connectivity organization of the basal ganglia and parafascicular nucleus. The analyses suggest that combinatorial gene expression underlies the modular and cell-type-specific basal ganglia input–output networks.