A CAR-T biotech’s dramatic turnaround, and drugmakers’ tactics to drive more scripts

How did a biotech company that almost ran out of money three times get acquired for over $3 billion? Will the M&A streak continue? And why are drugmakers working with a telehealth company called Prescribery?

We discuss all that and more on this week’s episode of “The Readout LOUD,” STAT’s weekly biotech podcast. Venture capitalist Bryan Roberts joins us to discuss his firm’s investment in Kelonia Therapeutics, the CAR-T biotech that Eli Lilly just said it would buy for $3.25 billion.

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<![CDATA[AXS-05 for Alzheimer disease agitation nears FDA decision date. ]]>

Understanding Collaborative CT and MRI Utilization Through Network Analysis: Retrospective Study Using Administrative Claims Data

<strong>Background:</strong> Japan has one of the highest densities of computed tomography (CT) and magnetic resonance imaging (MRI) scanners globally, yet efficient resource allocation remains a challenge amid demographic shifts and regional health care disparities. <strong>Objective:</strong> This study aimed to develop an analytic framework using network analysis techniques to understand the collaborative use of CT and MRI devices across health care facilities in a Japanese prefecture. <strong>Methods:</strong> A retrospective observational study was conducted using outpatient receipt data from Japan’s National Health Insurance and the Late-Stage Elderly Medical System, covering fiscal years 2016 to 2019. Network analysis techniques were used to identify patterns of shared use among medical institutions. Network graphs with community detection were developed to visualize collaborative relationships, and density and reciprocity metrics were calculated to assess interinstitutional cooperation. <strong>Results:</strong> CT examinations increased from 287,782 (2016) to 307,029 (2019), while MRI examinations increased from 107,876 to 115,929 over the same period. Collaborative examinations also increased for both modalities. Network density remained relatively stable (CT: 3.10-3.50×10<sup>-3</sup>; MRI: 3.20-3.70×10<sup>-3</sup>), while reciprocity decreased (CT: 9.74×10<sup>-2</sup> to 7.79×10<sup>-2</sup>; MRI: 2.82×10<sup>-2</sup> to 1.56×10<sup>-2</sup>). Community detection analysis showed differences in the distribution of medical institutions across clusters over time. <strong>Conclusions:</strong> Network analysis revealed structural changes in collaborative CT and MRI use patterns, including declining reciprocity, which suggests a shift toward more unidirectional referral patterns. This analytic framework provides a method for health care planners to assess interinstitutional collaboration and inform resource allocation strategies for shared diagnostic equipment.

Building a Science-Driven Business: How National Institutes of Health Funding Enabled an Evidence-Based Approach to Maternal Mental Health Innovation

The digital mental health (DMH) industry has grown drastically over the last decade; yet, many DMH products have failed to demonstrate meaningful clinical outcomes, in large part due to lack of scientific evidence. This viewpoint paper highlights an example of how early-stage DMH companies can prioritize science as a strategic advantage. We discuss Moment for Parents, an artificial intelligence–driven maternal mental health app built entirely with support from the National Institutes of Health (NIH) Small Business Innovation Research (SBIR) program. We illustrate the advantages and challenges of building a science-backed product with federal funding. Benefits include credible evidence generation, independence in product development, and enhanced market differentiation. We also discuss the challenges of navigating the SBIR ecosystem, including grant writing and administrative demands, and aligning business objectives with federal research priorities. By showcasing both the promise and complexity of SBIR funding, this viewpoint paper offers actionable insights for founders and chief executive officers who aim to prioritize science in the DMH space.
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