A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials

Nature Medicine, Published online: 01 July 2026; doi:10.1038/s41591-026-04514-3

Results from an individual participant data meta-analysis across 51 randomized trials challenge the assumption that the cardiovascular benefits from antihypertensive treatment compound over a prolonged duration of treatment.