<![CDATA[FDA accepts AXS-12 NDA for cataplexy in narcolepsy after phase 3 shows fewer attacks, better wakefulness, and cognition; decision due May 2027.]]>
Oxytocin in the amygdala links social and reward signals to cataplexy in mice
Nature Neuroscience, Published online: 14 July 2026; doi:10.1038/s41593-026-02349-2
Loss of orexin neurons in narcolepsy leads to sleepiness and cataplexy episodes, which are most common in social contexts. In a mouse model, an oxytocin-sensitive circuit in the central amygdala is both necessary and sufficient for cataplexy induced by socialization and reward, which links positive emotional signals to motor suppression and highlights a potential therapeutic target.
Oxytocin promotes socially triggered cataplexy
Nature Neuroscience, Published online: 14 July 2026; doi:10.1038/s41593-026-02352-7
In people with narcolepsy, cataplexy is often triggered by strong emotions in social situations. Mahoney et al. show that such cataplexy is mediated by oxytocin-responsive neurons in the amygdala that target brainstem regions regulating motor tone.
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<![CDATA[Explore today’s narcolepsy care: wake-promoting meds, oxybates for cataplexy, and pitolisant’s histamine boost—plus sleep habits that matter.]]>
<![CDATA[Explore today’s narcolepsy care: from sleep hygiene to stimulants, oxybates, and pitolisant—targeting sleepiness and cataplexy.]]>