Immersive virtual reality with synchronous neurostimulation for upper-limb recovery after stroke: a randomized feasibility trial

Nature Medicine, Published online: 26 June 2026; doi:10.1038/s41591-026-04486-4

A multimodal platform combining immersive virtual reality with a synchronous sensory neurostimulation protocol outperformed conventional rehabilitation in individuals with chronic stroke, driving upper-limb motor gains, restored body representation and improved tactile acuity while enabling objective kinematic tracking of recovery.

Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior

Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02331-y

Pascoli et al. show that nucleus accumbens dopamine transients evoked by reward-predictive cues encode subjective reward value in mice, predicting individual preference for drugs over natural rewards and forecasting vulnerability to compulsive drug-seeking behavior.

Cancer Immunotherapy Blossoms Are Starting to Bear Fruit

Over the last decade, there has been unprecedented success and progress in immunotherapy for cancer treatment, so says Ira Mellman, PhD, the president of research at the Parker Institute for Cancer Immunotherapy during his opening keynote at the Frontiers in Cancer Immunotherapy Symposium hosted by The New York Academy of Sciences, held on June 23, 2026.

Through his talk, Mellman described the research and clinical seeds that were sown over the last two decades. He showed how these seeds have blossomed, and his expectations for which blossoms will bear fruit, with the right focus and pruning.

Ira Mellman, PhD, the president of research at the Parker Institute for Cancer Immunotherapy during his opening keynote at the Frontiers in Cancer Immunotherapy Symposium hosted by The New York Academy of Sciences, held on June 23, 2026. [C. Singleman]

The last decade of cancer immunotherapy

Before considering therapeutic options, Mellman summarized the biological events required for stimulating an effective immune response in patients. He described the dual stages of T cell activation and T cell exhaustion. Most therapies have relied on interventions that activate T cells, but over time, these T cells become exhausted—they don’t die, but go into senescence.

The next logical step in therapeutic investigation was to explore methods to pull exhausted T cells from senescence back into an active state. While some new therapies are being tested, there is still significant work to be done and there have been many false starts.

Vaccine therapy has emerged to get ahead of the activation-exhaustion problem by developing primed and more efficient T cells.

“The sole purpose of vaccine therapy, as we think of it, is to generate more and better T cells by immunizing against presumptive tumor associated antigens or neo antigens and …having those cells feed into the cycle,” Mellman said. He explained that the idea behind using vaccines is akin to the goal of adaptive therapies, like CAR T, that increase the number of primed and functional T cells, but vaccines do it endogenously.

Broadening his scope further, Mellman spoke about cancers not just in terms of the direct interaction between cancer cells and T cells, but in the broader context of the body. “The tumor microenvironment (TME),” he said, “plays an immense role—both positive and negative—with respect to allowing T cells to do their jobs in the case of anti-tumor immunity.” Consideration of the interactions between cancer and the TME present both opportunities and challenges to developing therapies.

Current progress

“We’ve had unprecedented success both clinically and commercially” within the last 15 years for a variety of cancer therapies that have come from the research stage to FDA approval in a relatively short time. Mellman pointed out that these therapies not only have been created quickly, are effective across a variety of diseases, are well tolerated, and improve survival of patients.

“All of this activity together has really changed the standard of care in a wide variety of cancer types,” he stressed. “That this has happened over a 15-year period is truly extraordinary.”

Why is a renaissance needed?  

With this progress, Mellman returned to his original thesis that the field of cancer immunotherapy is on the precipice of big change.

He asked, “With this success—including clinical and financial—why do we need a renaissance in this area?” He answered his own question stating, that “We are the victims of our own success.”

He described challenges and setbacks stemming from the early progress. He described that identifying new checkpoint targets have not been successful, TIL research is somewhat successful, but outcomes are inconsistent, solid tumors post problems for therapies like CAR T, and cancer vaccines efficacy is unconfirmed except in their use as a post-operative adjuvant.

Reflecting on the history and progress, Mellman presented his four top priorities in progressing cancer immunotherapy over the next ten years. First, focusing on the next generation of cell therapy, especially focusing on treating solid tumors. Second, he suggests moving past CARs to using neoantigen-driven targeting (including vaccines, synthetic neoAg, and TCR platforms). Third, prioritizing in vivo immune engineering to reduce costs and improve accessibility and scalability. Fourth, he stresses the need to focus on a holistic approach to cancer immunology, understanding and optimizing the TME cancer interactions, developing synthetic modulators and utilizing AI models guided by patient insights.

Current steps to the future

Mellman further explained that through his work over the last two decades, he’s learned many lessons. He pointed out that researchers and clinicians need to remember that there are many therapeutic opportunities derived from various approaches; he cautioned against forgetting that mice are not humans and vice versa, pointing out that what may work in one species may not in the other; he encouraged the use of new technologies, including integrating AI into analysis procedures; and finally he suggested that researchers build on clinical research not just laboratory work.

Focusing on his own work, Mellman described how his team integrated these lessons in studying the application of mRNA vaccines. He described a study comparing the outcomes of patients with pancreatic cancer given mRNA vaccines intravenously (IV) or with an intramuscular (IM) dose. They were surprised to find that patients receiving IV delivery responded to the vaccine, but the response was inconsistent at first glance. Through deeper investigation, they determined that non-responsive patients previously had a splenectomy in addition to the removal of their pancreatic tumor. They reasoned that the IV infusion in responsive patients impacted immune cells developing in the spleen. While this study helped explain part of the process, Mellman pointed out that the fundamental mechanisms by which vaccines can be functional as an adjuvant are still unclear and his team is currently working on addressing these questions.

“There is a wealth of new understanding that we can generate if we move to the clinic quickly but do so in a way that really still concentrates on the underlying basic science,” he concluded. He stressed the importance of following approaches with an established proof of concept and suggested that engineering will enable research and scaling up to positively impact many patients.

Tending to the blossoming research and application of cancer therapy will allow for patients to have the opportunity to have better therapies in the future. Though he said this early in his discussion, it seems appropriate to end with Mellman’s assertion that, “This is a remarkable field.”

The post Cancer Immunotherapy Blossoms Are Starting to Bear Fruit appeared first on Inside Precision Medicine.

Imaging Technique Scans Entire Donor Livers for Transplant Viability

A new imaging approach to assess donor livers before transplantation could provide a much more comprehensive view of the condition of the whole organ, complementing conventional pathology tests that are typically restricted to localized areas. 

In a study published in Science Translational Medicine, researchers at the University of Oklahoma used polarization-sensitive optical coherence tomography (PS-OCT) to noninvasively measure multiple relevant parameters across the entire surface of donor livers. Using polarized light, this imaging technique was able to detect signs of steatosis, fibrosis, inflammation, and necrosis in donor livers—all of which are critical indicators of transplant viability. 

“PS-OCT offers a noninvasive assessment of liver viability by quantifying hepatic parameters across the entire donor liver, effectively complementing current pathological analysis,” write the authors of the study, led by Qinggong Tang, PhD, associate professor of biomedical engineering at the University of Oklahoma. “These results suggest that PS-OCT provides a robust approach to assessing donor liver viability, which could potentially decrease the discard rate of high-risk livers, thereby expanding the donor pool.”

Liver transplants are limited by a shortage of viable donor livers, which is driven by a high demand for donor livers and high rates of organ discard. In the U.S. alone, there are over 9,000 people on the liver transplant waitlist, which has driven healthcare providers to progressively expand the criteria used to evaluate potential donors. 

Assessing whether a donor liver is viable for transplantation currently relies on biopsies. However, these are invasive procedures that only provide information about the specific location within the liver the sample was taken from. As a result, this approach can sometimes miss critical signs of damage or disease elsewhere in the organ, potentially increasing the risk of transplanting a compromised liver. 

Tang and colleagues first evaluated the performance of PS-OCT imaging in discarded human donor livers, comparing the results to biopsies and functional tests. Using a machine learning algorithm to analyze the imaging data enabled the identification of key signs of injury and disease with 80% accuracy compared to conventional pathology assessments. The team then scanned five viable donor livers slated for transplantation and stratified them into different risk categories, accurately predicting clinical outcomes a week after transplantation. 

While biopsy tests can take several days to give back results, PS-OCT scans can produce a complete picture of the condition of the entire liver within about 15 minutes, offering a fast and noninvasive tool to assess multiple markers of transplant viability. Although the imaging technique is not intended to replace current evaluation methods, it could significantly reduce sampling error and add valuable information when screening potential donors. Ultimately, improving the assessment of donor livers could address the urgent need for increasing transplant numbers while simultaneously improving clinical outcomes for transplant recipients. 

The post Imaging Technique Scans Entire Donor Livers for Transplant Viability appeared first on Inside Precision Medicine.

Angry Kids: Dealing With Explosive Behavior

When a child — even a small child — melts down and becomes aggressive, they can pose a serious risk to themselves and others, including parents and siblings.

It’s not uncommon for kids who have trouble handling their emotions to lose control and direct their distress at a caregiver — screaming and cursing, throwing dangerous objects, or hitting and biting. It can be a scary, stressful experience for you and your child, too. Children often feel sorry after they’ve worn themselves out and calmed down.

So what are you to do?

It’s helpful to first understand that behavior is communication. A child who is so overwhelmed that they are lashing out is a distressed child. They don’t have the skill to manage their feelings and express them in a more mature way. They may lack language, impulse control, or problem-solving abilities.

Sometimes parents see this kind of explosive behavior as manipulative. But kids who lash out are usually unable to handle frustration or anger in a more effective way — say, by talking and figuring out how to achieve what they want.

Nonetheless, how you react when a child lashes out has an effect on whether they will continue to respond to distress in the same way or learn better ways to handle feelings so they don’t become overwhelming.

Behavioral techniques for anger management

Here are some pointers to help kids learn techniques to regulate their emotions:

  • Stay calm. Faced with a raging child, it’s easy to feel out of control and find yourself yelling at them. But when you shout, you have less chance of reaching them. Instead, you will only be making them more aggressive and defiant. As hard as it may be, if you can stay calm and in control of your own emotions, you can be a model for your child and teach them to do the same thing.
  • Don’t give in. Don’t encourage them to continue this behavior by agreeing to what they want in order to make it stop.
  • Praise appropriate behavior. When they have calmed down, praise them for pulling themselves together. And when they do try to express their feelings verbally, calmly, or try to find a compromise on an area of disagreement, praise them for those efforts.
  • Help them practice problem-solving skills. When your child is not upset is the time to help them try out communicating their feelings and coming up with solutions to conflicts before they escalate into aggressive outbursts. You can ask them how they feel and how they think you might solve a problem.
  • Time-outs and reward systems. Time-outs for nonviolent misbehavior can work well with children younger than 7 or 8 years old. When using time-outs, be sure to be consistent with them and balance them with other, more positive forms of attention. If a child is too old for time-outs, you want to move to a system of positive reinforcement for appropriate behavior — points or tokens toward something they want.
  • Avoid triggers. Vasco Lopes, PsyD, a clinical psychologist, says most kids who have frequent meltdowns do it at very predictable times, like homework time, bedtime, or when it’s time to stop playing, whether it’s Legos or video games. The trigger is usually being asked to do something they don’t like, or to stop doing something they do like. Time warnings (“we’re going in 10 minutes”), breaking tasks down into one-step directions (“first, put on your shoes”), and preparing your child for situations (“please ask to be excused before you leave Grandma’s table”) can all help avoid meltdowns.

What kind of tantrum is it?

How you respond to a tantrum also depends on its severity. The first rule in handling nonviolent tantrums is to ignore them as often as possible, since even negative attention, like telling the child to stop, can be encouraging.

But when a child is getting physical, ignoring is not recommended since it can result in harm to others as well as your child. In this situation, Dr. Lopes advises putting the child in a safe environment that does not give them access to you or any other potential rewards.

Critics of time-outs argue that they can be emotionally isolating for kids, but research shows that they are effective and do not cause children harm. (For more on the debate around time-outs, read our full article on the topic.) However, it’s very important to use them as just one technique in a nurturing, supportive parenting strategy. Be sure to balance use of time outs with lots of praise for kids’ positive behaviors. It’s also important to manage your own stress so that kids can learn how to regulate their emotions from your positive example.

If the child is young (usually 7 or younger), try placing them in a time out chair. If they won’t stay in the chair, take them to a backup area where they can calm down on their own without anyone else in the room. Again, for this approach to work there shouldn’t be any toys or games in the area that might make it rewarding.

Your child should stay in that room for one minute and must be calm before they are allowed out. Then they should come back to the chair for time out. “What this does is gives your child an immediate and consistent consequence for their aggression and it removes all access to reinforcing things in their environment,” explains Dr. Lopes.

If you have an older child who is being aggressive and you aren’t able to carry them into an isolated area to calm down, Dr. Lopes advises removing yourself from their vicinity. This ensures that they are not getting any attention or reinforcement from you and keeps you safe. In extreme instances, it may be necessary to call 911 to ensure your and your child’s safety.

Help with behavioral techniques

If your child is doing a lot of lashing out — enough that it is frequently frightening you and disrupting your family — it’s important to get some professional help. There are good behavioral therapies that can help you and your child get past the aggression, relieve your stress, and improve your relationship. You can learn techniques for managing their behavior more effectively, and they can learn to rein in disruptive behavior and enjoy a much more positive relationship with you.

  • Parent-child interaction therapy (PCIT). PCIT has been shown to be very helpful for children between the ages of 2 and 7. The parent and child work together through a set of exercises while a therapist coaches parents through an ear piece. You learn how to pay more attention to your child’s positive behavior, ignore minor misbehaviors, and provide consistent consequences for negative and aggressive behavior, all while remaining calm.
  • Parent management training (PMT). PMT teaches similar techniques as PCIT, though the therapist usually works with parents, not the child.
  • Collaborative and Proactive Solutions (CPS). CPS is a program based on the idea that explosive or disruptive behavior is the result of lagging skills rather than, say, an attempt to get attention or test limits. The idea is to teach children the skills they lack to respond to a situation in a more effective way than throwing a tantrum.

Figuring out explosive behavior

Tantrums and meltdowns are especially concerning when they occur more often, more intensely, or past the age in which they’re developmentally expected — those terrible twos up through preschool. As a child gets older, aggression becomes more and more dangerous to you, and the child. And it can become a big problem for them at school and with friends, too.

If your child has a pattern of lashing out it may be because of an underlying problem that needs treatment. Some possible reasons for aggressive behavior include:

  • ADHD: Kids with ADHD are frustrated easily, especially in certain situations, such as when they’re supposed to do homework or go to bed.
  • Anxiety: An anxious child may keep their worries secret, then lash out when the demands at school or at home put pressure on them that they can’t handle. Often, a child who “keeps it together” at school loses it with one or both parents.
  • Undiagnosed learning disability: When your child acts out repeatedly in school or during homework time, it could be because the work is very hard for them.
  • Sensory processing issues: Some children have trouble processing the information they are taking in through their senses. Things like too much noise, crowds and even “scratchy” clothes can make them anxious, uncomfortable, or overwhelmed. That can lead to actions that leave you mystified, including aggression.
  • Autism: Children with autism spectrum disorder are often prone to meltdowns when they are frustrated or faced with unexpected change. They also often have sensory issues that make them anxious and agitated.

Given that there are so many possible causes for emotional outbursts and aggression, an accurate diagnosis is key to getting the help you need. You may want to start with your pediatrician. They can rule out medical causes and then refer you to a specialist. A trained, experienced child psychologist or psychiatrist can help determine what, if any, underlying issues are present.

When behavioral plans aren’t enough

Professionals agree, the younger you can treat a child, the better. But what about older children and even younger kids who are so dangerous to themselves and others that behavioral techniques aren’t enough to keep them and others around them safe?

  • Medication. Medication for underlying conditions such as ADHD and anxiety may make your child more reachable and teachable. Kids with extreme behavior problems are often treated with antipsychotic medications like Risperdal or Abilify. But these medications should be partnered with behavioral techniques.
  • Holds. Parent training may, in fact, include learning how to use safe holds on your child so that you can keep both them and yourself out of harm’s way.
  • Residential settings. Children with extreme behaviors may need to spend time in a residential treatment facility — sometimes, but not always, in a hospital setting. There, they receive behavioral and, most likely, pharmaceutical treatment. Therapeutic boarding schools provide consistency and structure around the clock, seven days a week. The goal is for the child to internalize self-control so they can come back home with more appropriate behavior with you and the world at large.
  • Day treatment. With day treatment, a child with extreme behavioral problems lives at home but attends a school with a strict behavioral plan. Such schools should have trained staff prepared to safely handle crisis situations.

Explosive children need calm, confident parents

It can be challenging work for parents to learn how to handle an aggressive child with behavioral approaches, but for many kids it can make a big difference. Parents who are confident, calm, and consistent can be very successful in helping children develop the anger management skills they need to regulate their own behavior.

This may require more patience and willingness to try different techniques than you might with a typically developing child, but when the result is a better relationship and happier home, it’s well worth the effort.

Frequently Asked Questions

How can you deal with children’s anger?

One way to handle a child’s anger is to stay calm when they lose their temper. Controlling your emotions sets an example for the child. You can praise them when they express their feelings calmly and when they calm themselves down after an explosion. Adults who are confident, calm, and consistent help children develop the skills to regulate their behavior.

How do I teach a child to control their anger?

In parent-child interaction therapy, a therapist coaches parents on how to pay more attention to positive behavior, ignore minor misbehaviors, and provide consistent consequences for negative and aggressive behavior, all while remaining calm. Other forms of therapy also center on teaching the parent how to model emotional stability.

How can I calm a child down when angry?

Stay calm and ensure they are in a safe space. Yelling can escalate aggression. Speak in a steady voice, avoid giving in, and use time-outs to prevent meltdowns. When they calm down, praise them for it and for expressing their emotions appropriately. If they are frequently aggressive, behavioral therapy may help.

How do I help a child with anger issues?

Children who lash out often lack the skills to manage emotions. Identifying triggers, teaching problem-solving, and using praise or rewards can encourage better behavior. Time-outs work for younger kids, while older ones may need structured reinforcement. If outbursts are severe, you might need professional help. Programs like parent-child interaction therapy (PCIT), parent management training (PMT), or collaborative and practical solutions (CPS) can help.

The post Angry Kids: Dealing With Explosive Behavior appeared first on Child Mind Institute.

Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling

Nature Medicine, Published online: 25 June 2026; doi:10.1038/s41591-026-04481-9

Mass-spectrometry-based metabolomic analysis of plasma samples from multiple cohorts of patients treated with immunotherapy across five distinct tumor types, followed by machine learning enabled identification of metabolic signatures, as well as functional exploration, reveals association of increased plasma histidine levels with prolonged survival and its potential for therapeutic intervention.

Neoadjuvant stereotactic body radiation therapy with durvalumab and oleclumab in ER+HER2− breast cancer: a randomized phase 2 trial

Nature Medicine, Published online: 25 June 2026; doi:10.1038/s41591-026-04453-z

In the randomized phase 2 Neo-CheckRay trial, patients with early-stage ER+HER2− breast cancer received neoadjuvant immune-modulating stereotactic body radiation therapy with or without durvalumab, and with or without the anti-CD73 antibody oleclumab, leading to encouraging clinical responses when durvalumab was added including in patients with PD-L1-negative tumors.