Structuring Digital Mental Health Care Navigation: Co-Design Nominal Group Technique Study to Develop the MChart Definition and Typology of the Characteristics of Digital Mental Health Care Navigation Tools

<strong>Background:</strong> Australia’s mental health care system has been characterized by complexity and fragmentation, as highlighted by numerous reports, commissions, and inquiries. In response, digital mental health care navigation tools have emerged as a promising solution to help individuals locate appropriate mental health services. The rapid proliferation of these tools—without a clear understanding of their definitions and characteristics—risks creating confusion rather than clarity for users. Terms such as “navigation” and “navigators” are often used interchangeably, further complicating the landscape. <strong>Objective:</strong> This study addressed the need for a standardized definition and typology of the characteristics of digital mental health care navigation tools. <strong>Methods:</strong> This study was part of the development of a digital mental health care navigation tool for navigators and planners (MChart). It used a co-design approach using expert-based cooperative analysis, which is a nominal group technique to develop a definition and typology of the characteristics of digital mental health care navigation tools. This process was guided by the Technology Readiness Level for Implementation Sciences framework. The co-design process involved two 2-hour sessions with an expert panel comprising 28 participants, including representatives from mental health planning, primary health care, health care financing and delivery, community-managed organizations, clinical settings (psychiatrists, psychologists, and general practitioners), and consumers. <strong>Results:</strong> The expert panel collaboratively developed a consensus definition of digital mental health care navigation tools, outlining their scope and intended targets. Through the co-design process, the panel identified 157 characteristics of digital mental health care navigation tools. These characteristics were organized into 5 primary domains: type, management, content, design, and quality. The definition and typology characteristics provide a structured framework for understanding and evaluating the diverse range of digital mental health care navigation tools currently available. <strong>Conclusions:</strong> The co-designed definition and typology offer a foundational step toward reducing confusion in the digital mental health care navigation space. This study supports the development of quality standards that can be used to assess and compare existing and future tools. This framework has the potential to guide developers, end users, and policymakers in creating more effective, user-centered navigation solutions within Australia’s mental health care system and internationally.

A Digital Acceptance and Commitment Therapy and Education Intervention for Caregivers of Very Preterm Infants in the Neonatal Intensive Care Unit: Randomized Controlled Trial

Background: Parents of very preterm infants admitted to the neonatal intensive care unit (NICU) experience high levels of psychological distress, yet access to timely, evidence-based mental health support is limited by staffing and resource constraints. Digital mental health interventions offer a scalable approach to addressing this gap; however, their effectiveness has not been well established in NICU caregiver populations, particularly during periods of acute stress. Objective: This study aims to evaluate the effectiveness of a self-guided digital acceptance and commitment therapy (ACT)–based intervention combined with NICU-specific education (NICU parent acceptance and commitment therapy [NPACT]). The study explored the intervention’s effects on stress among parents and primary caregivers of very preterm infants, compared to a digital education-only intervention, and active control. Methods: We conducted a 3-arm, single-center, randomized controlled cluster trial in a tertiary NICU. Parents and primary caregivers of very preterm infants (<32 wk’ gestational age,<1 wk old) were randomized by family cluster to (1) NPACT (ACT+ education), (2) a digital education-only intervention, or (3) active control. Digital interventions were delivered via a web-based platform over 2 weeks. The primary outcome was NICU-related stress on the Parent Stressor Scale: Neonatal Intensive Care Unit (PSS:NICU) at 2 weeks postrandomization. Secondary outcomes included caregiver anxiety, depression, perceived stress, and selected neonatal outcomes. Engagement and perceived helpfulness were assessed for digital interventions. Results: A total of 102 caregivers from 68 family clusters (79 infants; mean gestational age 28.1, SD 2.2 wk) were enrolled. There were no statistically significant between-group differences in the mean PSS:NICU scores at 2 weeks (NPACT 3.0, SD 0.9; education-only 2.5, SD 1; active control 2.6, SD 0.9; adjusted mean difference for NPACT vs active control 0.04, 95% CI −0.39 to 0.47). No between-group differences were observed for secondary psychological outcomes at any time point. However, caregivers in both digital intervention groups had higher odds of full breastfeeding at discharge compared with active control. Engagement with the digital interventions was high, with 97% (28/29) of NPACT participants and 76% (19/25) of education-only participants completing at least 5 of 7 modules, and both interventions were rated as very helpful. Conclusions: In this trial, an unguided digital mental health intervention delivered during NICU admission did not reduce NICU-specific parental stress or other psychological outcomes relative to active control. However, the intervention was highly used by caregivers. These findings suggest that while a brief digital mental health intervention can be successfully implemented in a high-stress clinical setting with caregivers, its capacity to reduce acute psychological distress may be limited. Secondary findings indicate potential benefits of the digital intervention on breastfeeding, generating hypotheses for future research. Digital mental health interventions in neonatal settings may be most effective when integrated within hybrid models of care and/or delivered beyond the acute admission phase. Trial Registration: Australian New Zealand Clinical Trials Registry ACTRN12623000641695; https://tinyurl.com/2e8677bb International Registered Report Identifier (IRRID): RR2-10.1016/j.cct.2024.107519

“Physical Twins” of Human Arteries Predict Individual Stroke Risk 

Scientists in Australia have developed an artery-on-a-chip platform that can replicate a patient’s exact vascular structure to better assess their risk of ischemic stroke. Results published today in Cell Biomaterials show that differences in artery shape explain significant differences in stroke risk seen between patients with similar levels of artery narrowing. 

“Our findings suggested that three-dimensional vascular shape and local flow disturbances matter far more than simple narrowing,” said Yunduo Charles Zhao, graduate student at the University of Sydney and the Heart Research Institute in Newtown, Australia. “We hope these tools will allow us to study drugs aimed at reducing the risk of stroke and to eventually provide personalized treatments for each patient based on their anatomy.” 

Despite significant advances in imaging and management, stroke risk stratification is still very imprecise. Nearly 20% of patients receiving what is considered an optimal antiplatelet therapy continue to experience recurrent strokes, reflecting an incomplete understanding on how complex mechanical and biological factors determine whether clots grow, stabilize, or cause a stroke. 

“This idea was born out of a critical clinical gap,” said Lining Arnold Ju, PhD, associate professor at the University of Sydney in Australia and senior author of the study. “We know that even patients at ‘low risk’ can suffer from severe or fatal strokes. We wanted to find a better way to predict this risk.” 

Ju’s team used high-resolution 3D printing to create a “physical twin” that replicated the three-dimensional structure of the carotid artery from six patients who had previously experienced stroke of the carotid artery. To capture the full complexity of each patient’s unique physiology, the model also included the thrombogenic matrix and endothelium tissues, and simulated blood flow through the chip. 

“Our work recreates precise, patient-specific carotid artery geometries,” said Ju. “The physical twin also uses cells that more closely mimic the dynamics of blood flow in these structures.”

Using computer simulations, the researchers modeled blood flow through each carotid artery, uncovering substantial differences in local blood flow despite similar degrees of narrowing. They then used a laser to create an injury in the physical twins and study how blood clots formed, revealing that subtle differences in an artery’s shape could lead to strikingly different clotting responses. 

The researchers are currently recruiting patients with a stroke history for a clinical trial designed to evaluate the potential of this technology to improve diagnosis and treatment in underserved stroke patients. Down the line, the artery-on-a-chip physical twins could find applications in other cardiovascular conditions, such as peripheral artery disease, deep-vein thrombosis, and aneurysms. 

 

The post “Physical Twins” of Human Arteries Predict Individual Stroke Risk  appeared first on Inside Precision Medicine.

The Download: Chinese AI divides the White House, and a record copyright payout

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

China’s AI models have Trump’s AI world at war with itself

Last weekend, several current and former advisers to President Donald Trump on AI publicly lobbed insults at the country’s leading AI companies. David Sacks branded Anthropic’s models “lobotomized” and “woke.” Emil Michael, a top Pentagon official, called OpenAI’s new head of strategic futures a “supreme village idiot.”

It began because no one can agree on what to do about Kimi, a free, open-source model that Chinese AI company Moonshot launched last week. It appears to rival the intelligence of models from OpenAI and Anthropic, which are very much not free. 

Every time a new smart, free model from China gets released, US companies see less reason to fork out money for models from Anthropic or OpenAI. That’s creating economic and political problems for the president—and dividing the top AI strategists in his orbit. 

Read the full story on why no one can agree what to do about Kimi.

—James O’Donnell

This article is from The Algorithm, our weekly AI newsletter. Sign up to receive it in your inbox every Monday.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Anthropic’s record $1.5 billion copyright settlement has been approved
The plaintiffs said Anthropic used pirated works to train Claude. (Reuters $)
+ And won the largest known copyright payout in history. (Engadget)
+ Yet many authors and creators still don’t view it as a win. (TechCrunch)
+ But AI copyright anxiety could limit creativity. (MIT Technology Review)
 
2 The Trump administration is weighing a ban on Chinese AI models
The launch of Kimi K3 has revived calls for restrictions. (Axios)
+ But officials are divided on the proposals. (Fast Company)
+ China’s bet on open-source is paying off. (MIT Technology Review)
 
3 China is mulling tighter export controls on AI models and chips
It wants to stop the West from acquiring its tech and startups. (FT $)
+ Beijing has held talks with tech firms about potential restrictions. (Reuters $)
 
4 Trump’s AI safety head has resigned after just three months
Chris Fall had led CAISI, the federal AI Safety Institute, since April. (Axios)
+ No reason was given for his exit. (CNBC)
 
5 Google is working on a new chip to run Gemini models more efficiently 
The chip, called “Frozen V2,” may be deployed in 2028. (Information $)
+ Alphabet stock popped on the report. (CNBC)

6 New Orleans police have explored arming drones with weapons
A draft drone manual paves the way for weaponised quadcopters. (404 Media)
+ Shoplifters could soon be chased by drones. (MIT Technology Review)
 
7 The EU has handed AliExpress a record fine over unsafe product sales
The €550 million fine is the largest-ever under the Digital Services Act. (BBC)
+ Alibaba has vowed to appeal the fine. (SCMP)

8 Election advice from AI chatbots is “inaccurate and unreliable”
That’s the conclusion from tests in Hungary earlier this year. (Guardian)

9 Red light therapy is showing promise for healing and healthy aging
Better skin and reduced vision loss are also on the cards. (Economist $)

10 Neill Blomkamp’s new horror clip is all AI-generated—and it sucks
The acclaimed director wants to make “a full feature in this format.” (Gizmodo)

Quote of the day

“This would be a terribly self-defeating form of intervention if it were to happen.” 

—Tech investor Chamath Palihapitiya slams plans to restrict Chinese AI models in a post on X.

One More Thing

Surveillance camera on a pole against a dark blue sky

AKILAH TOWNSEND


Inside Chicago’s surveillance panopticon

Early on the morning of September 2, 2024, four people were shot and killed on a westbound train in Chicago. Police swiftly activated a digital dragnet—a surveillance network that connects thousands of cameras across the city—and arrested the suspect just 90 minutes later.

Law enforcement and security advocates say this vast monitoring system protects public safety and works well. But activists and many residents say it’s a surveillance panopticon that creates a chilling effect on behavior and violates guarantees of privacy and free speech.

Go inside the surveillance network that’s dividing Chicago.

—Rod McCullom

We can still have nice things

A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)

+ NASA has shared a stunning timelapse video of the Psyche spacecraft’s view of Mars.
+ This comparison of American and European Urbanism shows good city design is a choice.
+ Musician Luca Stricagnoli recently performed a marvellous acoustic guitar medley of Prodigy songs.
+ Two Australian paddleboarders saved a stranded wallaby after it was swept out to sea—and caught the whole rescue on video.

The Download: a useful quantum machine and a record-breaking subsea tunnel

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

PsiQuantum has a plan to make a massive quantum computer out of light

The machine that could change the world will be housed in a room that looks like a data center crossed with an ice cream factory. 

Inside, some 100 stainless-steel cabinets each hold hundreds of chips. On those chips, thousands of light particles will fly through a maze of optical switches and beam splitters. Each photon must be accounted for, because precisely measuring where it ends up will help answer questions that current computers might take millions of years to solve.

This computer, as described, does not exist. It’s the brainchild of a company called PsiQuantum, founded in 2016 by four physicists from UK universities. In a crowded field of deep-pocketed competitors with similarly fantastical visions, the company aims to be the first to build a useful quantum machine.

Read the full story on the company’s quest.

—James O’Donnell

MIT Technology Review Narrated: inside the world’s deepest and longest subsea road tunnel

—Niall Firth

I’m currently around 1,000 feet beneath the North Sea, in a dark, dank cave. It smells weird. And I’m increasingly aware of the pressure from millions of tons of seawater just above my head.

I’m under the iconic fjords of Norway to visit what will soon become the world’s longest and deepest subsea road tunnel—an exceptional engineering feat that will carry drivers deep beneath the North Sea.

I’m here to understand how you make a 16.6-mile highway that sits 1,280 feet below the sea at its deepest point. And also—at a time when it can feel hard to get anything done—to reassure myself that ambitious engineering is still possible. That we can still make things


This is our latest
story to be turned into an MIT Technology Review Narrated podcast, which we publish each week on Spotify and Apple Podcasts. Just navigate to MIT Technology Review Narrated on either platform, and follow us to get all our new content as it’s released.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Meta allegedly used AI to target workers with health issues for layoffs
Their lawsuit says Meta relied on AI to create a termination list. (Guardian)
+ And pinpointed staff who took maternity or disability leave. (Reuters $)
+ One was allegedly informed the day before her water broke. (Ars Technica)
+ The layoffs aimed to offset Meta’s AI spending. (Gizmodo)
+ AI agents are not your “coworkers.” (MIT Technology Review)

2 OpenAI’s first consumer device will be a mobile smart speaker
The screenless device will serve as an “AI companion.” (Bloomberg $)
+ It’ll let you talk with ChatGPT. (Verge)
+ And use a camera and sensor to understand your environment. (Reuters $)
+ It’s set to launch next year. (Engadget)
 
3 The US military sent explosive drone boats into combat for the first time
They attacked an Iranian midget submarine and naval port. (Ars Technica)
+ Underwater drones may shape a war in Taiwan. (MIT Technology Review)
 
4 DeepMind’s CEO has called for a US-led body to test frontier AI models
Demis Hassabis wants the watchdog to vet national security threats. (FT $)
+ If dangers mount, it would coordinate an industry-wide slowdown. (Axios)
 
5 Data centers are set to add billions in power costs in 13 states
A power auction is slated to produce $6.3 billion in new charges. (NYT $)
+ Australia plans to govern the use of water and power for AI. (WSJ $)

6 xAI’s unpermitted power pollution hits Black communities hardest
Elon Musk’s xAI has been installing gas turbines without permits. (Reuters $)
+ We need to focus on Big Tech’s energy footprint. (MIT Technology Review)
 
7 Stripe and Advent have offered to buy PayPal for more than $53 billion
The payments giant and private equity firm have made a joint bid. (Reuters $)
+ Apple and Google Pay have eroded PayPal’s market share. (Bloomberg $)

8 DeepSeek plans to file for IPO as soon as this year
The Chinese AI pioneer is likely to list in Shanghai. (WSJ $)
+ Here’s why DeepSeek’s latest model matters. (MIT Technology Review)

9 A hard, lightweight “bio-metal” has been discovered in sea worm jaws
It could have applications in engineering. (New Scientist $)

10 A new $3,000 fitness suit electrocutes you to boost your gains
Celebrities love it—but not everyone’s a fan. (404 Media

Quote of the day

“By economic and engineering measures, generative AI might be the worst technology ever deployed.” 

—Alex Reisner, a staff writer at The Atlantic, explains why GenAI’s scaling problem is an engineering disaster.

One More Thing

""

FRANZISKA BARCZYK


Hackers made death threats against this security researcher. Big mistake.

In April 2024, an anonymous hacker began posting death threats on Telegram and Discord channels aimed at a cybersecurity researcher named Allison Nixon. It wasn’t long before others piled on. Someone shared AI-generated nudes of her.

They targeted Nixon because she had become a formidable threat. As chief research officer at the cyber investigations firm Unit 221B, named after Sherlock Holmes’s apartment, she had built a career tracking cybercriminals and helping get them arrested. 

For years, Nixon had lurked quietly in online chat channels or used pseudonyms to engage with perpetrators and bring them to justice. Now, she resolved to unmask the people behind the death threats—and take them down for crimes they admitted to committing. 

Find out why they learned to regret their choice of target.

—Kim Zetter

We can still have nice things

A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)

+ A musician has discovered the true masters of metal breakdowns: birds.
+ Photographer Fontanesi’s surreal photo splits transform everyday images into spectacular hybrid scenes.
+ Over 30 actors, filmmakers, and friends recount how Steven Spielberg infiltrated Hollywood in this terrific article.
+ Who would win the World Cup if less important things than soccer decided it, like life expectancy and happiness? A new game tests your knowledge.

Fertility Treatment May Not Drive Cancer Risk

Women who undergo medically assisted reproduction (MAR) may have a slightly higher risk of developing certain hormone-related cancers, but a large Australian study suggests much of that increase is likely explained by underlying infertility, greater medical surveillance, and other patient characteristics rather than the fertility treatments themselves.

The findings, published in JAMA Network Open, analyzed data from nearly 1.75 million Australian women and represent one of the largest investigations to date of cancer risk following fertility treatment. Using an emulated target trial design—a statistical approach intended to better approximate the conditions of a randomized clinical trial—the researchers examined whether three common forms of MAR were associated with later cancer diagnoses.

The study included 1,748,927 women aged 18 to 55 years between 1991 and 2018, including 396,661 who had received some form of MAR. Treatments evaluated included assisted reproductive technology (ART), intrauterine insemination (IUI) or ovarian stimulation, and ovulation induction with clomiphene citrate.

Researchers found modest increases in the relative risk of several hormone-related cancers—including breast, ovarian, uterine, thyroid, colorectal cancers, and melanoma—after some fertility treatments. However, the absolute increase in risk was small.

For any individual invasive cancer, the investigators estimated that treated women experienced fewer than 20 additional cancers per 100,000 women per year compared with women who had not undergone MAR.

The authors emphasized that the observed associations should not be interpreted as evidence that fertility treatment causes cancer. “Although we observed increased relative risk for most hormone-related cancers following MAR, this corresponded to only small increases in estimated absolute excess risk,” the authors wrote.

To better distinguish treatment effects from other influences, the investigators incorporated several bias analyses rarely included in previous studies. They calculated E-values to estimate the impact of unmeasured confounding and analyzed cancers not believed to be hormonally driven—including pancreatic, lung, and hematologic cancers—as negative controls.

Those analyses suggested that underlying infertility-related conditions, such as endometriosis and polycystic ovary syndrome, as well as factors including obesity, anovulation, and demographic differences, could account for much of the increased risk observed for ovarian, uterine, and thyroid cancers.

The researchers also found that cancer diagnoses tended to cluster during the first few years after fertility treatment. According to the investigators, “Several emulated trials suggested a greater likelihood of incident cancer shortly after first treatment.” They noted that this pattern could reflect either accelerated growth of preexisting cancers or increased medical monitoring during fertility treatment and pregnancy.

After examining the data, the authors concluded that enhanced surveillance was the more likely explanation. “We believe detection bias is the more likely explanation for these results. This finding is the first empirical indication using a negative control that medical surveillance may be responsible for an increased risk of cancer following MAR,” they wrote.

Women pursuing fertility treatment often undergo repeated medical evaluations and may also be more likely to participate in cancer screening programs, increasing the likelihood that existing cancers are detected earlier than they otherwise would be.

Overall, the researchers concluded that while associations between MAR and hormone-related cancers were observed, the evidence does not support a simple causal relationship.

The investigators said the findings should reassure patients while also encouraging careful counseling and follow-up. They recommend that clinicians discuss the possibility of a small increase in cancer risk but explain that the excess risk “may be partially or fully due to the health and sociodemographic profile of women who receive MAR and increased surveillance during treatment.”

The authors added that routine surveillance after fertility treatment remains appropriate, but they cautioned that observed increases in cancer diagnoses should be interpreted within the broader context of infertility-related health conditions and differences in healthcare utilization rather than being attributed solely to fertility medications themselves.

The post Fertility Treatment May Not Drive Cancer Risk appeared first on Inside Precision Medicine.

PsiQuantum has a plan to make a massive quantum computer out of light

The machine that could change the world will be housed in a room that looks like a data center crossed with an ice cream factory. Inside will be some 100 stainless-steel cabinets, each about six feet tall and connected to a supply of liquid helium that keeps them only a few degrees above absolute zero. Inside those cabinets will be hundreds of chips, and on those, thousands of particles of light flying through a maze of optical switches and beam splitters. Each photon must be accounted for, because precisely measuring where it ends up will help answer questions that current computers might take millions of years to solve.

This computer, as described, does not exist. It’s the brainchild of a company called PsiQuantum, founded in 2016 by four physicists from UK universities. In a crowded field of deep-pocketed competitors with similarly fantastical visions, the company aims to be first to fulfill its promise.

In the years since the physicist Richard Feynman first envisioned them in 1981, quantum computers have promised to speed up everything from medical research to AI by harnessing the qualities of quantum particles. Unlike normal computer bits, which can be either a 1 or 0, quantum bits can exist in multiple states at once. And combining enough of those quantum bits together could produce a computer capable of tasks well beyond the reach of today’s conventional machines. But even today’s best quantum prototypes are too small and error-prone to do anything useful.

That makes PsiQuantum’s promises for what its computers will ultimately do all the more bold. Consider the company’s hopes for predicting the effects of cytochrome P450 enzymes, which often break down drugs in the body. If pharma companies knew more precisely how they would work on a particular molecule, they could design more effective medications faster. Estimating this for a specific drug can take over 10 years with today’s methods, says Philipp Ernst, vice president of quantum applications for PsiQuantum, but “we aim to get it down to four minutes.”

construction worker installing the Mk2.1 cabinet
The company’s chips will be contained in large cabinets. A quantum computer powerful enough to be commercially useful is expected to require roughly 100 of these cabinets connected together.
COURTESY OF PSIQUANTUM

In a field full of such claims, PsiQuantum has attracted unusual investment and scrutiny for two reasons: It is one of the few companies aiming directly at building a large and useful machine, and it is already working with a major chip manufacturer to build its systems using existing semiconductor fabs. Its vision has attracted momentum: Last year, PsiQuantum raised $1 billion in funding and broke ground in Chicago on a site it’s building in partnership with local governments. It also has a second site in the works in Australia, which it promises will be operational—meaning hardware-ready—in 2027. And it’s one of just two companies (along with Microsoft) to reach the third stage of an intensive government evaluation program to see which quantum companies might succeed.

Evaluating whether PsiQuantum will do what it says is harder than, say, judging a drugmaker by its clinical trial results: Advances in quantum computing are incremental, opaque, and tough to verify from the outside. But the company is now approaching its prove-it moment, when years of closed-door work and hundreds of millions in investment will either culminate in a useful quantum computer or fall short. We could start to know which as soon as next year.

A new kind of machine

Terry Rudolph, one of PsiQuantum’s four founders, is soft-spoken and shaggy-haired. He was born in Malawi and learned only after earning his first physics degree that he is a grandson of the famed physicist Erwin Schrödinger. He later self-published a 150-page book to explain quantum computing to teenagers (my PR contact gave me a signed copy with a wink that said “We never expect anyone to actually read this,” but I can report that it is a funny and helpful book). 

Around 2014, Rudolph and his cofounders became increasingly convinced that the quantum breakthroughs they were finding to be possible in theory might also be possible in a real machine. They eventually left their academic positions and divided the tasks before them: Rudolph worked on theory, Mark Thompson on engineering, Pete Shadbolt on scaling the technology up, and Jeremy O’Brien on articulating the vision and finding investors (O’Brien served as CEO until February; he’s been replaced by Victor Peng, a veteran of the semiconductor industry). 

To understand why the quantum computer the company is building would be a big deal, consider how imprecise much of modern science remains. We cannot reliably predict, for example, which lithium-ion battery will catch fire or how quickly a critical aircraft component will corrode.

This isn’t just because these systems are complex, though they are. It’s that, at their core, they are governed by quantum mechanics. Subatomic particles don’t have well-defined properties—this location and that velocity—but instead occupy quantum states spread across many possibilities. And that in turn influences a range of atomic and molecular behavior. Schrödinger (Rudolph’s grandfather, remember) showed how to describe this haziness mathematically a century ago this year, but precisely carrying out the calculations on real-world systems quickly becomes unfeasible even for the best computers. Scientists cope with this gap using approximations, imperfect simulations, or experiments on animals.

""

WINNI WINTERMEYER

WINNI WINTERMEYER

PsiQuantum co-founder and chief scientific officer Pete Shadbolt (left), and machinery the company has built to manufacture its own barium titanate, a material with the perfect qualities for routing light particles (right).

Feynman, David Deutsch, and other physicists in the 1980s wondered if we could do better. Maybe such complexity could instead be modeled using a new kind of machine. Rather than using transistors that are only ever on or off, this one would use particles held in quantum states, manipulate them to perform calculations, and then measure them at the end for an answer. Using quantum systems to simulate quantum systems would for the first time allow a simulation of physics and chemistry that directly reflected reality. It would be an invaluable tool for designing new drugs, materials, or really anything affected by quantum mechanics. Revolutionary, in other words.

Humankind’s leaps in understanding how nature works have often resulted in the invention of powerful new tools, Rudolph told me. “I don’t think it’s a coincidence that the Industrial Revolution coincided with our ability to calculate and simulate the laws of Newtonian mechanics, the laws of thermodynamics,…the laws of classical electromagnetism,” he says. “Whenever we have more power to calculate and simulate and understand things, we build incredible machines that come from it.” He sees something similar coming with quantum computers.  

Chasing photons

One mystery has always been which quantum thing—ions, atoms, or something entirely new engineered with quantum properties—could be made stable and controllable enough to use as a qubit, the basic unit in the quantum computing world. Quantum systems are delicate, and observing any particular particle causes it to collapse into one state rather than a superposition of multiple states. If this happens during the computation rather than at the end, it produces an error that must be corrected for. Too many of these means the computer fails to produce a useful answer. 

Just as engineers in the early days of aviation weren’t sure whether airplane wings would be fixed or flap like a bird’s, we’re not yet sure which of these quantum things will work best. Google and IBM are betting on superconducting qubits, superconducting circuits made of aluminum or other metals. Intel is using electrons. PsiQuantum is using photons, the particles that make up light.

“Photons have lots of nice things going for them,” Rudolph says. They can maintain quantum states for a long time; indeed, the photons in the universe’s cosmic microwave background may have done so for billions of years. But photons also move fast and scatter easily. More importantly, two photons are more likely to pass through one other than interact. That makes them a challenging candidate for quantum computation, in which qubits need ways to influence one another. 

For a while, this last flaw seemed to doom the idea of quantum computing with light. But in 2001, researchers from the Los Alamos National Laboratory and the University of Queensland found a loophole. They discovered they could essentially fake interactions between photons by sending the light particles through a network of beam splitters and detectors. Their paper changed everything. PsiQuantum was created to make the theory a reality.

Size was the first problem; previous plans would have required a computer as large as California. Mercedes Gimeno-Segovia, who was a PhD student of Rudolph’s in the early 2010s (after almost becoming a professional violinist instead), thought of a way for the machine to be smaller. 

The basic process since then has been this: First create photons with lasers and then “entangle” them, exploiting a quantum phenomenon in which the particles no longer have individual states but instead share one. Next, route them through a maze of gates that perform computations, and finally read out details of their quantum state at the end, all while tracking and correcting for the errors that occur. Succeeding at each of these steps millions of times is not so much an engineering hurdle as a brick wall. And building the supply chain—like manufacturing new materials with the qualities to route individual photons around—is arduous.

A sizable chunk of PsiQuantum’s funding is being spent on custom cooling machinery that uses tanks of liquid helium to cool the company’s chips. Shown here is part of the PsiQuantum’s cooling system at a facility in Milpitas, California.
COURTESY OF PSIQUANTUM

To get a sense of it all, last year I joined Shadbolt at the SLAC National Accelerator Laboratory, in Menlo Park, California. The center has helped produce several Nobel Prizes and played a role in the 1968 discovery of quarks, fundamental building blocks of matter that make up protons and neutrons. But PsiQuantum set up shop there essentially to siphon liquid helium from SLAC’s giant cryoplant. This is what the company uses to cool its computing cabinets down to deep-space temperatures.

Right now the cabinets operate at 2 K, or -456 °F, but the goal is to be able to run them slightly warmer—at a balmy -452 °F. Most quantum approaches require the whole machine to be cooled to superconducting temperatures, so that much of the expense in running it will actually be spent on refrigeration. But photonic computers require only one piece to be this cold—the detectors that measure single photons at the end of the computation. And the required temperature can be a bit higher. (PsiQuantum said in May that it will spend some of the $100 million award in CHIPS Act funding it’s slated to get on these detectors). 

The siphoning setup was a temporary solution; PsiQuantum now has its own cooling system at its testing facility in Milpitas, California, and is setting up a larger one at its production site in Australia next year. These helium systems represent some of the biggest capital expenditures for any quantum company and will consume a significant chunk of PsiQuantum’s $1 billion funding round.

In the afternoon we drove to a lab in San Jose, where I donned a cleanroom suit—a head-to-toe covering that keeps dust at bay—to watch the manufacture of a blueish crystal called barium titanate. 

It’s prized by PsiQuantum because it quickly and reliably routes light particles with very little electrical input, keeping the precious photons undisturbed as they move through the circuit. But for all barium titanate’s theoretical value to the company, its structure makes it a pain to manufacture, and the material wasn’t available at scale when PsiQuantum got its start. The company, in what Rudolph told me was an agonizing decision, opted to make it in-house, requiring a massive investment. I saw a technician—operating at what looked like a giant pressure cooker—adding the base elements to several hoppers; then I watched through a porthole as the elements got heated, vaporized, and finally crystallized into a thin layer on a wafer disc. At that time each disc took about 12 hours to make; the company now says several are produced each day. The discs then get shipped to the chipmaker GlobalFoundries in Malta, New York, where PsiQuantum’s chips are made.

WINNI WINTERMEYER

WINNI WINTERMEYER

The company has invested heavily in making its own barium titanate, a material whose delicate crystalline structure is tedious to manufacture.

PsiQuantum’s bet is that this entire supply chain, byzantine as it might sound, will make the company more efficient than its competitors. That’s because, if you squint, it looks like a souped-up and high-precision version of the existing supply chain for silicon photonic chips, another type of technology that transmits information with light—one that’s already used in data centers. If PsiQuantum produces its chips at scale, it can take advantage of tools and infrastructure that already exist.

But it’s not a given that one working chip can easily be wired up to thousands more. That’s why the company is testing in phases: Its Milpitas site has connected three cabinets together, with 250 chips in each, but the next step is to scale the systems up and see whether the company’s techniques for correcting errors can keep up. Once the cooling system arrives at the Australian site late next year, the company says, it aims to connect about 100 cabinets together. Then PsiQuantum will work up to running the world-changing algorithms it has promised.

The timeline for this, it’s worth noting, is up for debate. News articles have said that 2027 is the year that PsiQuantum aims to have its first full-scale quantum computer come online at its Australian site, but the company insists the deadline has been misread, and that it only intends for its facility to be “operational” by the end of next year. That means cooling systems in place and ready for hardware to be installed, but no promises about what size computer will be ready. In an industry where timelines are perpetually in flux yet central to how companies are judged, that distinction isn’t trivial.

Into the unknown

The outsider with perhaps the best guess of whether PsiQuantum will succeed is the Pentagon. The US Defense Advanced Research Projects Agency—the Pentagon’s research and development arm—has been running an initiative to determine which of the boastful quantum companies might actually deliver. In the last year and a half, the heads of the program have been sounding more confident. Joe Altepeter, who ran the program until last year and proudly described himself as a “quantum skeptic,” told me in March 2025: “I am more optimistic now than I have been at any point in the past 10 years.” And in a statement earlier this year, his successor, Micah Stoutimore, said “it now seems likely that someone will build a utility-scale quantum computer by 2033,” referring to a machine that generates more value from its calculations than it costs to build and operate. 

The program has been scrutinizing PsiQuantum’s systems for over a year and putting them through the third stage of a benchmarking initiative meant to determine whether the technology will actually work. But to the rest of the industry, PsiQuantum is sort of a black box.

PsiQuantum has broken ground at the Illinois Quantum and Microelectronics Park outside Chicago, pictured here, and on another site in Moreton Bay, Australia. It aims to build large-scale quantum computers at each site.
COURTESY OF PSIQUANTUM

“It is very hard for an outsider to evaluate,” says Scott Aaronson, a theoretical computer scientist at the University of Texas at Austin who runs a popular blog that often covers the industry. Other companies, like Google and Quantinuum, have regularly published results over the years demonstrating chips and systems with incremental improvement, publicly laying the engineering groundwork needed to eventually build large machines.

PsiQuantum has instead focused squarely on a commercial goal—a computer with one million qubits, which is the scale that researchers expect to unlock research currently not possible on normal computers. PsiQuantum often differentiates itself with this industrial-scale goal, but IBM, which debuted a development road map in 2020, has been progressively building bigger and bigger systems. It initially targeted 2028 for a large-scale, error-corrected system, a deadline that now appears to have been pushed out to 2030.

Making it useful

On top of actually building the machine, a major focus for PsiQuantum is getting the rest of the world to develop a plan for how to use it. PsiQuantum has announced partnerships with customers including the defense giant Lockheed Martin, which intends to use it for materials design; the automaker Mercedes, which wants it for battery design; and the aerospace manufacturer Airbus.

That these companies don’t have a computer to experiment with is not a problem, according to Ernst at PsiQuantum. “There’s a PlayStation 6 probably coming up from Sony next year or the year after, and people are programming those games right now,” he says. “This is, in principle, very similar.” (It’s a glib analogy but not an entirely empty one; the quantum algorithms for solving a research problem can be cracked even if there is not yet hardware to run them on.) 

The idea is that experts in quantum information from both PsiQuantum and its customers will be able to translate design problems—say, the requirements for a battery in a Mercedes electric vehicle—into algorithms the computer could solve. The company offers a software package called Construct, which companies can use to design their own algorithms that might one day run on the computer.

The future of quantum computing hinges on these algorithms. Quantum computers get painted as a speedup for everything, but in reality, they’re suited to a subset of problems, and answering a question with this sort of machine requires the question to be formulated with very specific types of algorithms. People spend entire careers working on such algorithms, even if the computers to run them don’t exist yet. At their core, they use the rules of quantum mechanics to manipulate probabilities in ways that ordinary computers can’t. 

The most famous example, and a reason the government is so interested in quantum computers, is Shor’s algorithm. It was developed in 1994 by the theoretical computer scientist Peter Shor and could effectively break many forms of encryption used online, for everything from credit card numbers to military intelligence. The thing keeping the world together, for now, is that nobody has a computer to run the algorithm on (and security experts are already launching new encryption methods that could withstand attacks from a quantum computer). PsiQuantum is researching how long its systems might take to run Shor’s algorithm.

WINNI WINTERMEYER

WINNI WINTERMEYER

PsiQuantum’s chips are manufactured at GlobalFoundries in Malta, New York, and tested at company headquarters in California. Both PsiQuantum and GlobalFoundries have been awarded federal CHIPS Act funding.

The company also published a paper in December in collaboration with Airbus, essentially seeing if a new algorithm developed by the authors could beat a classical computer in modeling fluid dynamics, like the turbulence around an airplane wing. Andrew Childs, an expert in quantum simulation, told me PsiQuantum achieved only a moderate speed increase over what today’s computers can do. “It’s probably unlikely that speedups like this will have a significant practical impact until we have very large-scale quantum computers,” he said in an email. (When I asked Ernst, he agreed the improvement was modest.)

Some of the algorithms PsiQuantum is working on are not expected to be perfected or even used in the first applications of its computer. Instead, its initial tasks might be more along the lines that Feynman envisioned way back in 1981: simulating the smallest particles of our world. 

The company’s most significant research in this realm is in modeling quantum chemistry. Take those pesky P450 enzymes. More precisely understanding how they operate, PsiQuantum says, would allow for faster drug development and testing.

Last year, PsiQuantum published methods for doing these sorts of chemistry calculations on a quantum computer, along with another paper demonstrating an algorithm that can simulate the collision of two molecules and estimate the likelihood of different outcomes femtosecond by femtosecond (there are one quadrillion femtoseconds in a second). It’s a remarkable amount of detail not currently possible with today’s technology, and it would allow drug and materials researchers to simulate new chemical interactions. 

Dominic Berry, who developed some of the core techniques used in the collision paper but isn’t involved in PsiQuantum, says the company made impressive improvements, but to do the simulations scientists are most curious about would require the algorithm to be made even faster and PsiQuantum’s early computer to have fewer errors than currently expected.

Until PsiQuantum’s computers are up and running, the breakthroughs that these research papers tease remain in the realm of theory. It’s a space where Rudolph operates quite comfortably. He told me that Alan Turing created the theory of classical computing with pen and paper, imagining how the 1s and 0s would be represented in the machine, and how with the right approach to logic you could compute almost anything. 

“But there is no way that by hand, with a pen and paper, Turing was ever going to produce—you know—Minecraft and Facebook,” he says. That took more than 70 years of tinkering (during which we fortunately created more useful things than Minecraft and Facebook).

For all the time Rudolph spends dreaming up things quantum computers might do, in other words, people working on those problems are still stuck with pen and paper for now: “Until you have the actual machine in hand, you don’t have the opportunity to really explore its potential.”

Mung Bean Pan-Genome Study Maps Key Genes for Yield, Nutrition, and Pest Resistance

Because Mung beans (Vigna radiata) are nutritious, inexpensive, have nitrogen-fixing capacity, and are relatively easy to grow with a short growing cycle, they are an important crop for food security in many parts of Asia, Africa, and other regions. Now, researchers have made a significant contribution to a landmark international study that has uncovered tens of thousands of previously hidden structural variations influencing yield, nutritional quality, insect resistance, and other relevant mung bean traits.

The study entitled, “Graph-based pan-genome reveals structural variations associated with agronomic traits in mung bean,” published in Nature Genetics, presents the world’s first graph-based pan-genome for the pulse crop (a legume grown specifically for its dry edible seeds) offering a comprehensive resource for understanding the genetic basis of key agronomic traits and accelerating crop improvement.

The international research team, co-led by researchers at the Chinese Academy of Agricultural Sciences and Murdoch University’s Centre for Crop and Food Innovation (CCFI), assembled chromosome-scale genomes from genetically diverse mung bean accessions and analyzed genomic variation across 580 global accessions. The resulting graph-based pan-genome captures more than 75,000 gene families and identifies over 66,000 structural variants, offering important insights that will help breeders target key agronomic traits and accelerate crop improvement.

More specifically, the authors note that, “integrating these structural variants and single nucleotide polymorphisms, genome-wide association studies across five environments identified candidate genes for 20 agronomic traits, underscoring the pivotal roles of these variants in driving mung bean domestication and improvement.”

Mechanistically, they add, the work demonstrates that “a 68-bp promoter insertion in VrTIFY6B and a 136-bp promoter deletion in VrPGIP1 regulate flavonoid content and confer bruchid resistance, respectively.”

In Australia, mung bean generates over $100 million annually in export revenue. At roughly three times the price of wheat, it represents a highly profitable break crop opportunity for Australian growers; however, seasonal rainfall variability continues to drive significant year-to-year swings in the size and value of the crop.

By cataloging tens of thousands of previously invisible structural variations and linking them to agronomic traits through genome-wide association analysis, this new genomic resource gives breeders a far more complete map of the genetic variation they can work with.

Globally, where mung bean underpins the diets and incomes of millions of smallholder farmers across Asia and Africa, the study’s findings on genes governing seed nutritional compounds and resistance to bruchids, a major storage pest, have direct implications for global food security.

Rajeev Varshney FRS FAA, CCFI director, said the research represents a major advance in crop genomics and demonstrates how next-generation genomic technologies are transforming plant breeding. “Traditional reference genomes capture only part of the genetic diversity within a crop species. By constructing a graph-based pan-genome, we can now identify structural variations that were previously invisible but often have profound effects on important agricultural traits.

“These discoveries provide breeders with powerful new genomic tools to accelerate the development of higher-yielding, more nutritious and climate-resilient mung bean varieties,” Varshney continues. “The genomic resources generated through this work will support marker-assisted breeding, genomic selection and genome editing, enabling breeders to deliver improved varieties to farmers much faster.”

The post Mung Bean Pan-Genome Study Maps Key Genes for Yield, Nutrition, and Pest Resistance appeared first on GEN – Genetic Engineering and Biotechnology News.

The Download: a donor conception cap and world models for AI

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Sperm donors need limits, says a European fertility group

Ties van der Meer doesn’t know how many siblings he has. The 47-year-old was conceived at a private fertility clinic using sperm from an anonymous donor. He eventually tracked down one sibling, but he may have others he’ll never find. 

Other donor-conceived people have found they have tens or even hundreds of them. “It does make you feel a bit mass-produced,” said one who discovered they had 25 half-siblings.

In response, a European fertility organization says we need international limits on the number of children a single donor can contribute to. 

Find out what their proposal could achieve—and where it may fall short

—Jessica Hamzelou

This story is from The Checkup, our weekly biotech newsletter. Sign up to receive it in your inbox every Thursday.

How will AI understand the real world?

LLMs have transformed what AI can do with language, but helping machines understand and operate within physical spaces presents a different challenge. In response, researchers are developing a new form of artificial intelligence: world models.

At a LinkedIn Live event tomorrow, MIT Technology Review will explore how this technology could shape the future of robotics and open one of AI’s next major frontiers. Join Will Douglas Heaven, our senior editor for AI, and Sam Sinha, founding AI researcher and head of world models at 1X Technologies, for the conversation on Tuesday, July 14. 

Register here to attend the free session at 9:30 PDT, 12:30 PM EDT, and 5:30 PM BST. 

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Apple has sued OpenAI for allegedly stealing trade secrets
OpenAI purportedly stole IP to develop its own consumer hardware. (CNBC)
+ The suit claims OpenAI poached Apple staff to access the information. (BBC)
+ And requested trade secrets in job interviews with Apple workers. (Guardian)
+ Apple also sued two former employees, Chang Liu and Tang Tan. (Reuters $)

2 A Nobel-winning chemist is leaving the US to lead an AI lab in China
Omar Yaghi will head an institute using AI to discover new materials. (LA Times $)
+ He won a Nobel Prize in Chemistry for creating “molecular sponges.” (NYT $)
+ His departure comes as China tries to woo US scientists. (Nature)
+ The White House has slashed science spending. (MIT Technology Review)
 
3 The EU is moving closer to banning children from social media
It’s proposed barring under-13s unless supervised by an adult. (NYT $)
+ And limiting access for older children. (Bloomberg $)
+ The EU has also told Meta to disable autoplay and infinite scroll. (Politico $)
 
4 Meta scrapped an AI image feature on Instagram after a backlash
It allowed users to generate images based on public accounts. (TechCrunch)
+ And automatically opted in any Instagram user with a public account. (NYT $)
+ AI memories are privacy’s next frontier. (MIT Technology Review)
 
5 Phoebe Gates’ shopping app claimed credit for sales it didn’t drive
Phia claimed unearned affiliate sales through fake clicks. (Bloomberg $)
+ Cofounder Gates is the daughter of Microsoft cofounder Bill. (Engadget)
 
6 Leaked police drone footage exposes the new reality of surveillance
Hours of San Francisco Police video were accidentally released. (Wired $)
+ Surveillance from drones is on the rise in the US. (MIT Technology Review)
 
7 Over two-thirds of Americans back a Sanders-style AI ownership plan
A poll found strong support for public ownership of AI stock. (Gizmodo)
+ Tech firms have their own takes on the idea. (MIT Technology Review)

8 AI may soon make campaign text messages more potent—and irritating
AI platforms are training bots to sound like political candidates. (NPR)

9 An orbiting disco ball gave Einstein’s theory its most precise test yet  
It measured Earth’s twisting of space-time more precisely. (Rest of World)

10 Australia’s biggest radio hit may be the product of GenAI
Musicians are questioning how the song was made. (Guardian)

Quote of the day

“LOL, I found out I can access the [network storage], so funny.” 

—A text message sent by former Apple engineer Chang Liu to a colleague, which a new lawsuit alleges was part of a scheme to steal hardware IP for OpenAI.

One More Thing

view of an unmanned sub from the nose
Colombian military officials intercepted this 40-foot-long uncrewed fiberglass “narco sub” in the ocean just off Tayrona National Park.
CARLOS PARRA RIOS


How uncrewed narco subs could transform the Colombian drug trade

On a bright April morning in 2025, a surveillance plane operated by the Colombian military spotted a 40-foot-long “narco sub” idling in the Caribbean Sea. The stealthy vessel, used by drug cartels to move cocaine north, could sail with its hull almost entirely underwater.

After seizing the boat, the coast guard noticed something unusual: there was no one on board. This was Colombia’s first confirmed uncrewed narco sub, operable by remote control, but also capable of a degree of autonomous travel.

Uncrewed subs could move more cocaine over longer distances, and they won’t put human smugglers at risk of capture. Find out how they may transform the drug trade.

— Eduardo Echeverri López

We can still have nice things

A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.)

+ Metallica’s “Enter Sandman” has been reinvented as a yacht rock track.
+ Two super-puff planets lighter than cotton candy have been spotted floating through space.
+ An inventor has given Tic Tac fans (like Donald Trump) a solution to the box’s annoying rattling in their pockets.
+ Imbibe a dose of adrenaline with this first-person footage of a rider on heart-pounding Red Bull Genova Cerro Abajo.

Genetic Map Opens Door to Development of New Therapies to Reverse Bone Loss

An international team of scientists report that they have successfully mapped the cells and genes that regulate bone formation and loss and discovered the critical role that blood vessel cells play in bone health. By combining genomic sequencing with data from half a million individuals, the research team identified hundreds of previously unknown genes that govern bone health and revealed cells surrounding blood vessels as one of the drivers of bone repair.

The study “Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease” is published in Nature Genetics. The team says its findings fundamentally enhance our understanding of skeletal disease. It is hoped the discovery will enable the development of new therapies to rebuild lost bone, offering hope to almost half of all individuals over 50 living with rare and common skeletal conditions such as osteoporosis, osteoarthritis and osteogenesis imperfecta, as well as those with rare bone disorders and cancers that spread to bone.

“Most people don’t realize that bones are constantly changing; the human body replaces its skeleton every 10 years or so,” said Peter Croucher, PhD, professor at the Garvan Institute of Medical Research in Australia. “This is a hugely important process, but until now we’ve had a limited understanding of the cells and mechanisms that control this turnover of bone. “Most of the drugs now available focus only on halting bone disease, rather than rebuilding lost bone, which is really important for reversing damage.”

Detailed map of cells and genes that regulate bone health

The team used single-cell RNA sequencing to measure which genes are switched on within individual cells found in bone, focusing on the interface between the hard bone and bone marrow which is the key site for the formation and breakdown of bone.

The Institute’s Ryan Chai, PhD, pointed out that the team’s analysis found 34 different groups of cells and defined the genes that are active in each of these cell types. “To our surprise, more than half of the genes identified have never before been shown to play a role in maintaining bone health, which is a significant finding,” he added.

Ryan Chai, PhD, and Peter Croucher, PhD, from the Garvan Institute of Medical Research. [Garvan Institute]
Ryan Chai, PhD, and Peter Croucher, PhD, from the Garvan Institute of Medical Research [Garvan Institute]

The team used its map to identify cells involved in rare and common skeletal diseases, including osteogenesis imperfecta and osteoporosis. For the latter, the researchers analyzed the UK Biobank, one of the world’s biggest and most comprehensive collections of biological samples.

By analyzing genetic and bone density data from half a million people participating in the UK Biobank, the team was able to pinpoint exactly which cells drive skeletal disease, according to John Kemp, PhD, associate professor from Mater Research.

“These include cells known to regulate bone formation and bone loss, as well as blood vessel cells that, until now, have had underappreciated roles in bone health,” he said.

Croucher explained that the research uncovered new therapeutic opportunities against not only bone disease, but also cancer. “Bone is the main hiding place for dormant cancer cells and a common site of relapse, so identifying the cells and genes that drive bone turnover also opens new opportunities to prevent cancer metastasis,” he said.

The team is now further investigating the roles of newly discovered bone-regulating cells and genes in the hope of developing new medicines against these targets. Its data has been made accessible to medical researchers worldwide through an open access platform.

 

 

The post Genetic Map Opens Door to Development of New Therapies to Reverse Bone Loss appeared first on GEN – Genetic Engineering and Biotechnology News.