Exposure to negative physical and social factors accelerates brain aging

Nature Medicine, Published online: 21 April 2026; doi:10.1038/s41591-026-04348-z

In a study that included 18,701 people from 34 countries, 73 aggregated physical and social exposomes exhibited nonlinear, synergistic effects that accelerated brain aging. In some cases, these effects were comparable to or stronger than those of mild cognitive impairment and dementia. Environmental inequities might shape brain aging and demand multisectoral and structural policy responses.

Biophysical modeling of excitation/inhibition balance and conversion to psychosis in the clinical high risk syndrome

Reduced mismatch negativity (MMN) and P300 event-related potential (ERP) components are widely replicated in schizophrenia and are also observed in individuals at clinical high risk for psychosis (CHR-P) who subsequently convert to psychosis. It is unknown whether they reflect changes in excitatory and/or inhibitory synaptic function, both implicated in schizophrenia and considered potential drug targets.

AACR 2026: A Video Update from San Diego

The American Association for Cancer Research (AACR) meeting is off and running in San Diego. Julianna LeMieux, PhD, Deputy Editor in Chief at GEN, and Damian Doherty, Editor in Chief at Inside Precision Medicine, are on the ground—in the talks, expo hall, and press room, covering as much of the news as they can. Here, they take a moment to chat about the first few days at the meeting.

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CPC Biotech debuts unified bioprocess fluid portfolio

NEWS RELEASE: Introducing CPC Biotech – one brand uniting critical fluid management components New brand unites CPC’s Biopharma connector products with PSG Biotech’s pump, flow meter and sensor expertise – creating an integrated portfolio for the biopharmaceutical industry CPC Biotech to make its public debut at INTERPHEX 2026, April 21–23, Javits Center, New York City Roseville,…

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Regulatory tips from a breakthrough noninvasive device startup

Compremium’s noninvasive Quantis CVP (central venous pressure) measurement device joined the FDA’s Total Product Life Cycle Advisory Program (TAP) after earning Breakthrough Device designation in January 2026. The FDA designed TAP to “help spur more rapid development of high-quality, safe, effective, and innovative medical devices that are critical to public health” and expedite patient access…

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