Radically different
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Dr. Shinya Yamanaka is recognized for the generation of induced pluripotent stem cells (iPSCs) from fibroblasts by a combination of multiple transcription factors, and he won the Nobel Prize in Physiology or Medicine in 2012 jointly with Sir John B. Gurdon for this discovery. Twenty years after the discovery, the Cell Reports Medicine editorial team discusses with Dr. Yamanaka the scientific, technical, and translational milestones that have shaped the field of regenerative medicine. We also discuss the role of iPSCs in disease modeling and drug discovery, the interplay with genome editing, and ongoing issues that still prevent the widespread clinical application of iPSC-derived therapies.
A deeply phenotyped healthy Hong Kong cohort reveals age- and sex-dependent immune, clinical, and lifestyle variation, highlighting population-specific differences and the need to extend systems immunology frameworks beyond European ancestry.
Bellut et al. show that the NLRP3 inflammasome drives hyperacute inflammation and infarct progression during large vessel occlusion in stroke. Pharmacological inhibition reduces infarct growth in mice. NLRP3-positive cells in human pial blood before thrombectomy correlate with clinical outcome and highlight a potential therapeutic target prior to recanalization.
Hang et al. identify an out-of-frame CBX3::ALK fusion in metastatic melanoma that generates functional ALK isoforms through alternative translation start sites. This study demonstrates that rare noncanonical out-of-frame fusions can be oncogenic and therapeutically actionable, highlighting an analytic blind spot in current gene fusion detection pipelines.