This Comment discusses depth, robustness and bias in plasma proteomics, concluding that increasing the depth of coverage does not necessarily translate to quantitative robustness.
The US Supreme Court’s decision in Loper Bright Enterprises v. Raimondo, along with federal spending cuts, may limit the potential of synthetic biology to provide innovative solutions for environmental challenges, medicine and biomanufacturing.
The analysis of the 100 Million Brazilian database reveals that a past tuberculosis diagnosis increases the risk of death up to 14 years later regardless of treatment outcome, which should prompt urgent prioritization of global prevention efforts.
The authors propose five high-priority areas to close the current gaps in diagnostic testing, providing a path to self-reliance in health security and universal healthcare in Africa.
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Good morning. Big news: I’ve convinced at least one other STAT staffer to re-read “The Odyssey” with me ahead of the movie this summer. Starting today, that means we’ll read three books (chapters), or about 1,500 lines, per week for the next eight weeks. Care to join us?
Artificial intelligence is moving quickly in the enterprise, from experimentation to everyday use. Organizations are deploying copilots, agents, and predictive systems across finance, supply chains, human resources, and customer operations. By the end of 2025, half of companies used AI in at least three business functions, according to a recent survey.
But as AI becomes embedded in core workflows, business leaders are discovering that the biggest obstacle is not model performance or computing power but the quality and the context of the data on which those systems rely. AI essentially introduces a new requirement: Systems must not only access data — they must understand the business context behind it.
Without that context, AI can generate answers quickly but still make the wrong decision, says Irfan Khan, president and chief product officer of SAP Data & Analytics.
“AI is incredibly good at producing results,” he says. “It moves fast, but without context it can’t exercise good judgment, and good judgment is what creates a return on investment for the business. Speed without judgment doesn’t help. It can actually hurt us.”
In the emerging era of autonomous systems and intelligent applications, that context layer is becoming essential. To provide context, companies need a well-designed data fabric that does more than just integrate data, Khan says. The right data fabric allows organizations to scale AI safely, coordinate decisions across systems and agents, and ensure that automation reflects real business priorities rather than making decisions in isolation.
Recognizing this, many organizations are rethinking their data architecture. Instead of simply moving data into a single repository, they are looking for ways to connect information across applications, clouds, and operational systems while preserving the semantics that describe how the business works. That shift is driving growing interest in data fabric as a foundation for AI infrastructure.
Losing context is a critical AI problem
Traditional data strategies have largely focused on aggregation. Over the past two decades, organizations have invested heavily in extracting information from operational systems and loading it into centralized warehouses, lakes, and dashboards. This approach makes it easier to run reports, monitor performance, and generate insights across the business, but in the process, much of the meaning attached to that data — how it relates to policies, processes, and real-world decisions — is lost.
Take two companies using AI to manage supply-chain disruptions. If one uses raw signals such as inventory levels, lead times, and supply scores, while the other adds context across business processes, policies, and metadata, both systems will rapidly analyze the data but likely come up with different conclusions.
Information such as which customers are strategic accounts, what tradeoffs are acceptable during shortages, and the status of extended supply chains will allow one AI system to make strategic decisions, while the other will not have the proper context, Khan says.
“Both systems move very quickly, but only one moves in the right direction,” he says. “This is the context premium and the advantage you gain when your data foundation preserves context across processes, policies and data by design.”
In the past, companies implicitly managed a lack of context because human experts provided the missing information, but with AI, there is a shortfall and that creates serious limitations. AI systems do not just display information; they act on it. If a system does not explain why data matters, an AI model may optimize for the wrong outcome. Inventory numbers, payment histories, or demand signals might be accurate, but they do not necessarily reveal which customers must be prioritized, which contractual obligations apply, or which products are strategically important. As a result, the system can produce answers that are technically correct but operationally flawed.
This realization is changing how companies think about AI readiness. Most acknowledge that they do not have the mature data processes and infrastructure in place to trust their data and their AI systems. Only one in five organizations consider their approach to data to be highly mature, and only 9% feel fully prepared to integrate and interoperate with their data systems.
Don’t consolidate, integrate
The emerging solution is a data fabric: An abstraction layer that spans infrastructure, architecture, and logical organization. For agentic AI, the fabric becomes the primary interface, allowing agents to interact with business knowledge rather than raw storage systems. Knowledge graphs play a central role, enabling agents to query enterprise data using natural language and business logic.
The value of the data fabric relies on three components: Intelligent compute to provide speed, a knowledge pool to provide business understanding and context, and agents to provide autonomous action are grounded in that understanding. What makes this powerful is how these capabilities work together, says Khan.
The technology provides the architecture — a foundation that makes agent-to-agent communication and coordination possible. The process will define how businesses and IT share ownership, and establish governance and a culture in which people trust enough to adopt it. Now all three things must work together for a business data fabric to truly be successful.
“It empowers confident, consistent decisions, and when these elements all come together, AI just doesn’t analyze and interpret the data — it drives smarter, faster decisions that really create business impact,” he says. “This is the promise of a thoughtfully designed business data fabric, where every part reinforces the other, and every insight is grounded in trust and clarity.”
Technically, building a data-fabric layer requires several capabilities. Data must be accessible across multiple environments through federation rather than forced consolidation. A semantic or knowledge layer is needed to harmonize meaning across systems, often supported by knowledge graphs and catalog-driven metadata. Governance and policy enforcement must also operate across the fabric so that AI systems can access data securely and consistently.
Together, these elements create a foundation where AI interacts with business knowledge instead of raw storage systems — an essential step for moving from experimentation to real enterprise automation.
Beyond data isolation and dashboards
In the emerging era of agentic AI, the responsibility for monitoring, analyzing, and making decisions based on data increasingly shifts to software. AI agents can monitor events, trigger workflows, and make decisions in real time, often without direct human intervention. That speed creates new opportunities, but it also raises the stakes. When multiple agents operate across finance, supply chain, procurement, or customer operations, they must be guided by the same understanding of business priorities.
Without a common knowledge layer connecting disparate data together, coordination between systems quickly breaks down. One system might optimize for margin, another for liquidity, and another for compliance, each working from a different slice of data.
Importantly, most enterprises already possess much of the knowledge needed to make this work, says Khan. Years of operational data, master data, workflows, and policy logic already exist across business applications — companies just need to make it accessible. Companies that deploy data fabrics gain greater trust in their data, with more than two thirds of enterprises seeing improved data accessibility, data visibility, and exerting more control over their data.
“The opportunity isn’t just inventing context from scratch, it’s activating and connecting the context across your business that already exists,” he continues, adding that a data fabric is the “architecture that ensures data semantics, business processes and policies are connected as a unified system across all the clouds.”
This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff. It was researched, designed, and written by human writers, editors, analysts, and illustrators. This includes the writing of surveys and collection of data for surveys. AI tools that may have been used were limited to secondary production processes that passed thorough human review.
Los Angeles deserves its reputation as the quintessential car city—the rhythms of its 2,200 square miles are dictated by wide boulevards and concrete arcs of freeways. But it once had a world-class rail transit system, and for the last three decades, the city has been rebuilding a network of trolleys and subways. In May, a new four-mile segment with three new subway stations will open along Wilshire Boulevard, a key east-west corridor that connects downtown LA to the Pacific Ocean. What today can be an hours-long drive through a busy, museum-packed stretch of the city will be, if all goes well, a 25-minute train ride.
The existence of subway stops in this part of town—known as Miracle Mile—is a technological triumph over geography and geology. The ground underneath it is literally a disaster waiting to happen—it’s tarry and full of methane. One of those methane deposits actually exploded in 1985, destroying a department store in the neighborhood. In response, the city pushed its new train routes to other parts of town.
These days, dirt full of flammable goo is no longer a problem. “The technology finally caught up with the concerns,” says LA Metro’s James Cohen, a longtime manager of the engineering for this stretch of subway. The key was an earth-pressure-balance tunnel-boring machine, an automated digger that is designed to chew through ground packed with explosive gas. It sends removed dirt topside via conveyor belts and slides precast concrete liner segments into the tunnel, which are joined together with gaskets to create a gas- and waterproof tube. All that let the machine dig about 50 feet every day.
A Metro train pulls into La Cienega stationArt by Susan Silton at the Fairfax stationArt by Eamon Ore-Giron at the La Brea station
Meanwhile, engineers excavated the stations from the street level down. They worked mostly on weekends, digging out a space and then decking it with concrete so that work could go on underneath while LA drivers continued to exercise their God-given right to get around by car above.
Did the project finish on time? No. Did it come in under budget? Also no; this segment alone cost nearly $4 billion. Is the city now racing to build housing and walkable areas to take full advantage of the extension? Oh, please. Yet the new stations still manage to feel, in the end, transformative—as if Los Angeles’s train has finally come in.