STAT+: Makary departs FDA amid turmoil as Diamantas, agency’s top food official, steps in

WASHINGTON — Food and Drug Administration Commissioner Marty Makary is resigning from his role, and Kyle Diamantas, the top food regulator at the agency, will step in as acting commissioner.

President Donald Trump confirmed Makary’s resignation while taking questions from reporters ahead of his trip to China.

“He’s going to go on and he’s going to lead a good life,” Trump said of Makary. “He was having some difficulty. He’s a great doctor. He’s going to go on and do well. Everybody wants that job.”

Continue to STAT+ to read the full story…

Finding Answers When Your Child Is Struggling: Introducing Ask Kai 

Every day, parents reach out to the Child Mind Institute with questions that keep them up at night: Why does my daughter have such strong emotions? Why can’t my son sit still in class? Is this normal anxiety or something more?.

These questions are urgent, but finding answers isn’t easy. The wait time to see a children’s mental health professional can be months or even years. Many families don’t know where to start, what’s normal for their child’s age, or whether their concerns warrant professional help. And with nearly 1 in 5 children experiencing a mental health challenge within the U.S. alone, too many families are navigating this uncertainty on their own.

That’s why we built Ask Kai — a free, evidence-based symptom checker designed specifically for children’s mental health, available in both English and Spanish.

Meet Ask Kai

Ask Kai is a conversational symptom checker that helps parents and caregivers understand their child’s behavior and points them to appropriate resources. Through a streamlined series of questions and prompts, Ask Kai gathers information about your child’s challenges and provides personalized recommendations in minutes.

Ask Kai doesn’t diagnose your child. Instead, it helps you:

  • Understand whether your concerns align with common mental health challenges
  • Learn what to look for and what questions to ask
  • Find evidence-based resources specific to your child’s needs
  • Know how to find additional support if needed

Think of Ask Kai as a knowledgeable guide who helps you make sense of what you’re seeing and points you toward your next best step.

How Ask Kai works

If you’ve ever used a symptom checker for physical health, you know the challenge: enter “headache,” and you might walk away convinced you have everything from a sinus infection to a brain tumor. Mental health symptom checkers face even greater challenges. Because every child is different, what looks like defiance in one child could look like anxiety in another, and a behavior that’s appropriate at age five might be cause for concern at age ten. On top of that, mental health conditions often overlap.

So how did we build a tool that captures this complexity without overwhelming families? We focused on expertise and evidence:

  • Clinicians and data lead the way: Ask Kai was built using thousands of child mental health evaluations — open datasets spanning different ages, backgrounds, and conditions — and developed in close collaboration with child psychologists and psychiatrists.
  • Evidence-based question selection: Rather than asking hundreds of questions, we used machine learning to identify which combinations of questions provide the most meaningful information without burdening families.
  • Comprehensive resource library: Every recommendation Ask Kai makes is matched to our extensive collection of guides, articles, expert perspectives, and pathways to professional help.

Here’s what happens when you use Ask Kai

Step 1: Initial Screening

You’ll answer a brief set of questions about your child’s behavior, emotions, and how these challenges affect daily life. You’ll also have the chance to describe in your own words what brought you to Ask Kai. These questions cover the areas where we see the most common concerns.

Step 2: Personalized Deep Dive

Based on your responses, Ask Kai selects targeted follow-up questions that dig deeper into the areas you flagged, whether that’s attention and focus, social anxiety, learning, or other behavioral challenges.

Step 3: Matching You to Resources

Ask Kai analyzes your complete response pattern, including the severity and impact of the behaviors you described, and provides a report with recommendations relevant to your child’s age, challenges, and needs.

What Ask Kai can assess

We designed Ask Kai to explore the areas where we can provide the most help to the most families. Ask Kai offers comprehensive screening and resources for:

ADHD (Attention-Deficit/Hyperactivity Disorder)

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is characterized by difficulties with attention, organization, and impulsive behaviors. Symptoms are usually divided into inattentive behaviors or hyperactive and impulsive behaviors. Inattentive symptoms may include making careless mistakes, being easily distracted, difficulty listening to instructions, trouble with organization, and forgetfulness. Hyperactive/impulsive symptoms may include fidgeting or squirming, trouble playing quietly, extreme impatience, as well as constant talking and interrupting.

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that begins in utero, but children may not get diagnosed until they’re in preschool or even older, when symptoms become more apparent. The disorder is characterized by deficits in social communication skills as well as restrictive or repetitive behaviors. Symptoms include a wide range of impaired cognitive abilities, language skills, and behaviors. These symptoms have been thought of as a set of disorders but are now being considered one disorder that presents along a spectrum.

Depression

Depression is a mood disorder that can cause children and teenagers to feel very sad and hopeless. Kids with depression have trouble enjoying things they used to love. They may also seem listless and easily annoyed.

Generalized Anxiety Disorder

Generalized anxiety disorder is characterized by excessive, persistent, and unreasonable worries about everyday things, like doing well in school or sports. In general, kids with this disorder worry a lot about being perfect.

Oppositional Defiance Disorder

Oppositional defiance disorder is a disruptive behavior disorder characterized by ongoing persistent, age-inappropriate disobedience and resistance to authority. To be diagnosed with this disorder, children would have had to display extreme behavior issues for at least six months. Diagnosis occurs around early elementary school ages and stops around adolescence.

Social Anxiety Disorder

Social anxiety disorder is a type of anxiety characterized by such intense self-consciousness and fear of embarrassment in social situations that the individual avoids social events; also known as social phobia. While some kids with this disorder are specifically afraid of performance engagements like public speaking or sporting events, others are scared of general social situations.

Specific Phobia

Specific phobia is an anxiety disorder characterized by an excessive and irrational fear of an object, situation, or place. Common specific phobias include dogs, clowns, bugs, the dark, and loud noises.

Elimination Disorders (Enuresis & Encopresis)

For young children, bathroom troubles are often a normal part of growing up. But once kids pass potty-training age, peeing or pooping in places other than the toilet might be a sign of an underlying issue. If it involves urine, it’s called “enuresis.” If it involves feces, it’s called “encopresis.”

Nonverbal Learning Disorder (NVLD)

Nonverbal learning disorder (NVLD) is a condition characterized by difficulty processing visual-spatial information — which involves the brain’s ability to interpret and respond to visual input, including where things are in space. These skills are used to do things like putting together a puzzle or reading a diagram.

Specific Learning Disorder (Dyslexia, Dyscalculia, & Dysgraphia)

Specific  learning disorder is a condition that causes children to have difficulty with reading, writing, and/or math. If they have trouble with reading, the disorder is called dyslexia. If they have trouble with writing, it’s called dysgraphia. If they have trouble with math, it’s called dyscalculia. Symptoms are typically first noticed when the child is in preschool or early elementary school.

These ten areas represent some of the most common mental health concerns in childhood. They’re also areas where we have robust data, validated assessments, and comprehensive resources.

What if your concerns aren’t on this list?

Ask Kai can still help. When you describe your situation in your own words, Ask Kai analyzes your response to identify additional concerns and match you to appropriate resources. Your child’s challenges don’t need to fit neatly into one of these categories for Ask Kai to provide value.

However, we will only make recommendations when we’re confident in the evidence behind them. If a particular concern isn’t well represented in our data, we won’t try to provide guidance in that area. Regardless of the results, everyone receives a core set of resources that we believe are helpful for all families navigating children’s mental health.

Your privacy matters

We take data privacy seriously:

  • Your responses are confidential and secure
  • Free-text responses are analyzed using secure AI systems
  • We don’t share your individual information with third parties
  • In addition to providing you with resources, your data will only be used to improve Ask Kai

Try Ask Kai Today

If you’re wondering whether your child’s behavior is typical or cause for concern, Ask Kai can help. In just 10 to 15 minutes, you’ll get personalized insights and resources to guide your next steps.

Start Your Assessment

You don’t have to figure this out alone. We’re here to help.

If your child is in crisis, expressing thoughts of self-harm, experiencing severe symptoms, or in immediate danger, please seek emergency help right away. Call 988 (Suicide and Crisis Lifeline), text “HELLO” to 741741 (Crisis Text Line), or go to your nearest emergency room.

Frequently Asked Questions

How long does it take?

Most families complete Ask Kai in 10–15 minutes.

Who should use this tool?

Parents, caregivers, and professionals working with children ages 4–18.

Will I get a diagnosis?

No. Ask Kai provides screening information and resources, but only a qualified clinician can provide a diagnosis.

What if I need immediate help?

If your child is in crisis, please call 988, text “HELLO” to 741741, or visit your nearest emergency room.

What makes this different from other symptom checkers?

Ask Kai was built specifically for children’s mental health, uses evidence-based assessments, provides personalized follow-up questions, and was developed in close collaboration with child mental health professionals.

The post Finding Answers When Your Child Is Struggling: Introducing Ask Kai  appeared first on Child Mind Institute.

Supreme Court extends mifepristone deadline

Get your daily dose of health and medicine every weekday with STAT’s free newsletter Morning Rounds. Sign up here.

Good morning. My co-workers and pals Isabella Cueto and Lev Facher have been talking about alcohol for years. As STAT’s reporters on chronic disease and addiction, respectively, it’s right at the intersection of their beats, yet rarely covered as a public health issue. I’m happy to share that all their talking turned to reporting, and now an incredible series. The first parts are up now. Scroll down or skip ahead to start reading

Read the rest…

World Models: 10 Things That Matter in AI Right Now

World models recently made our list of 10 Things That Matter in AI Right Now. Watch executive editor Niall Firth explain why this emerging area of AI is gaining so much attention.

Join MIT Technology Review editors and reporters for a subscriber-only Roundtables discussion, “Can AI Learn to Understand the World?” exploring how AI may evolve to better reason about the real world and what this could mean for the future of AI systems.

Related Stories:

Speakers:

Mat Honan
Editor in Chief
Will Douglas Heaven
Senior Editor, AI
Grace Huckins
AI Reporter
<![CDATA[Joseph F. Goldberg, MD, urges evidence-based psychiatric deprescribing: continual med reviews, shared decisions, and smarter polypharmacy reduction.]]>
<![CDATA[Anti-inflammatory drugs ease anhedonia and depressive symptoms in high-CRP depression, spotlighting CRP-guided treatment and lifestyle strategies while calling for stronger RCTs.]]>

Applications Open for the SNF Global Center Communicator Fellowship

The Stavros Niarchos Foundation (SNF) Global Center for Child and Adolescent Mental Health at the Child Mind Institute launches its next two-year fellowship for professionals pursuing evidence-based approaches across diverse, underserved global communities

New York, NY—Applications are now open for the 2026 Communicator Fellowship at the Stavros Niarchos Foundation (SNF) Global Center for Child and Adolescent Mental Health at the Child Mind Institute. The fellowship is designed to support a new generation of communicators working to shape child and adolescent mental health care in low- and middle-income countries, in addition to the SNF Global Center’s core country offices in Brazil, Greece, and South Africa. Up to three professionals working in public communications, including journalists, broadcasters, and podcasters, will be selected for the two-year program.

The Communicator Fellowship is part of the SNF Global Center’s broader mission to reduce gaps in data and care, catalyze system-level advancements, and transform child and adolescent mental health care by turning evidence into action, scaling culturally appropriate solutions, and building a global network of experts so young people everywhere can access support when they need it.

The application deadline is June 15, 2026. Fellows will be selected and announced by early August 2026. In addition to financial support of up to $100,000 USD, fellows will receive training, mentorship, and networking opportunities.

At a time when one in five young people are experiencing mental health or learning challenges, with most cases beginning by age 14, effective and accurate communication is urgently needed.

At the Child Mind Institute, we believe that translating research into accessible knowledge that empowers young people, families, and communities is integral to advancing mental health care. The Communicator Fellowship builds on this commitment by supporting professionals who can bring evidence-based mental health information to the public in clear, engaging, and culturally relevant ways.

Vinicius Gaby Vieira Rego, MD, of Brazil, a current Communicator Fellow with the support of the Institute of Psychiatry at the University of São Paulo, exemplifies this mission. Working with youth, Dr. Rego is co-creating a multi-platform literacy hub designed to combat harmful misinformation by empowering Brazil’s young leaders.

“I am deeply grateful for the opportunity to join the SNF Global Center’s network of fellows to support adolescent mental health in Brazil through communication,” said Dr. Rego. “This fellowship will enable a multi-channel communication project aimed at strengthening mental health literacy and peer-support capacity — with young people and for young people — across the country.”

As a fellow, Dr. Rego’s work directly addresses complex mental health challenges faced by young people in Brazil, while contributing to broader global efforts to improve communication about mental health care.

“In the current digital environment, where adolescents are exposed to a high volume of mental health content, the need for evidence-based information that resonates with young people has never been greater,” said Guilherme Polanczyk, MD, PhD, associate professor of Child and Adolescent Psychiatry at the University of São Paulo. “We are proud to endorse a project committed to supporting how young people and their communities understand and reflect on their mental health.”

Other current fellows are leading high-impact projects dispelling misinformation, reducing stigma, and increasing youth engagement — all while bringing critical attention to links among mental health, climate change, and human rights. Through partnerships, these efforts are transforming the future of youth mental health across the globe.

“Vinicius’s project is ambitious, and with the support of the Institute of Psychiatry at the University of São Paulo, we know it will provide young people in Brazil with much-needed resources to support their mental health,” said Peter Raucci, Director of Global Fellowship Strategy of the SNF Global Center at the Child Mind Institute. “What we’re seeing through the Communicator Fellowship is how quickly ideas can move from concept to culturally relevant, real-world impact.”

SNF Global Center Communicator Fellowship

Application deadline: June 15, 2026

Fellows announced: August 2026

Program resources


About the SNF Global Center at the Child Mind Institute
The Stavros Niarchos Foundation (SNF) Global Center for Child and Adolescent Mental Health at the Child Mind Institute brings together the Child Mind Institute’s expertise as a leading independent nonprofit in children’s mental health and the Stavros Niarchos Foundation’s deep commitment to supporting collaborative projects to improve access to quality health care worldwide. The center is building partnerships to drive advances in under-researched areas of children and adolescents’ mental health, and expand access to culturally appropriate training, resources, and treatment in low- and middle-income countries. This work is conducted by the Child Mind Institute with support from SNF through its Global Health Initiative (GHI).

About the Child Mind Institute
The Child Mind Institute is dedicated to transforming the lives of children and families struggling with mental health and learning disorders by giving them the help they need. We’ve become the leading independent nonprofit in children’s mental health by providing gold-standard, evidence-based care, delivering educational resources to millions of families each year, training educators in underserved communities, and developing tomorrow’s breakthrough treatments.

The post Applications Open for the SNF Global Center Communicator Fellowship appeared first on Child Mind Institute.

Effects of Patient Portal Message Framing on Treatment Preferences and Expectations for Degenerative Meniscus Tears: Randomized Exploratory Cross-Sectional Survey Study

<strong>Background:</strong> Degenerative meniscus tears are common in middle-aged and older adults, and current guidelines favor nonoperative care. As patients increasingly turn to portal systems to view imaging results and communicate with their physicians, patient-facing wording may shape downstream treatment preferences and expectations. <strong>Objective:</strong> This study aimed to determine whether subtle differences in physician message framing about an identical degenerative meniscus tear influence preferred management, expectations for improvement with conservative therapy, and satisfaction when a physician recommends a different plan. <strong>Methods:</strong> A cross-sectional 37-question survey was developed de novo and distributed in January 2026 to lay adults in the United States (≥18 years) recruited via Amazon Mechanical Turk. Respondents were presented with a standardized vignette of an adult aged 60 years with knee pain due to a degenerative meniscus tear. Participants were randomized in a 1:1:1 fashion into 3 physician portal message framing groups: neutral, degenerative, and damage. Outcomes were the preferred next step in treatment, expected improvement with physical therapy, and retained satisfaction under physician-respondent disagreement. Chi-square and Fisher exact tests were used to compare categorical variables. Multivariable logistic regression analyses were used to assess associations between framing groups. <strong>Results:</strong> Of the 266 completed responses, 195 (73.3%) were included for analysis (neutral: n=67, 34.4%; degenerative: n=63, 32.3%; damage: n=65, 33.3%). Treatment preferences differed significantly across groups (<i>χ</i><sup>2</sup><sub>2</sub>=6.1; <i>P</i>=.047), and the damage group was significantly more likely to prefer aggressive interventions (odds ratio 2.43, 95% CI 1.17-5.06; <i>P</i>=.02). Expectations for physical therapy success differed significantly (<i>χ</i><sup>2</sup><sub>4</sub>=12.3; <i>P</i>=.02), with the damage group being most pessimistic about conservative care. Retained satisfaction under physician-respondent disagreement did not differ by framing group (<i>χ</i><sup>2</sup><sub>6</sub>=6.7; <i>P</i>=.35) but did differ significantly by initial treatment preference (<i>P</i>=.03) and was the lowest among respondents preferring steroid injection. <strong>Conclusions:</strong> In this exploratory investigation, subtle differences in physician portal message framing regarding a magnetic resonance imaging impression of a degenerative meniscus tear were associated with shifts in treatment preferences and confidence in conservative care. These findings suggest that brief physician portal communications may be associated with shifts in hypothetical patient expectations and treatment preferences before clinical counseling occurs. <strong>Trial Registration:</strong>
<![CDATA[How FDA priority review vouchers speed psychedelic therapy approvals.]]>